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    Txnrd3 thioredoxin reductase 3 [ Mus musculus (house mouse) ]

    Gene ID: 232223, updated on 2-Aug-2017
    Official Symbol
    Txnrd3provided by MGI
    Official Full Name
    thioredoxin reductase 3provided by MGI
    Primary source
    MGI:MGI:2386711
    See related
    Ensembl:ENSMUSG00000000811 Vega:OTTMUSG00000021186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TGR; TR2; AI196535
    Summary
    The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is evidence for additional isoforms resulting from the use of a non-AUG (CUG), and an in-frame downstream AUG as translation initiation codons (PMID:20018845). [provided by RefSeq, Aug 2017]
    Orthologs
    Location:
    6; 6 D1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (89643988..89675529)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (89593982..89625523)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 6 Neighboring gene predicted gene, 46966 Neighboring gene NADH dehydrogenase [ubiquinone] 1 subunit C2-like Neighboring gene vomeronasal 1 receptor, pseudogene 25 Neighboring gene vomeronasal 1 receptor 40

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    electron carrier activity IEA
    Inferred from Electronic Annotation
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein disulfide oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    thioredoxin-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxygen radical IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    thioredoxin reductase 3
    Names
    thioredoxin and glutathione reductase
    thioredoxin reductase TR2
    NP_001171529.1
    NP_001171530.1
    NP_001171531.1
    NP_694802.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001178058.1NP_001171529.1  thioredoxin reductase 3 isoform 1

      See identical proteins and their annotated locations for NP_001171529.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant and longer transcript. It contains two in-frame translation initiation codons: an upstream non-AUG (CUG) and a downstream AUG codon. The isoform (1, also known as TGR-L) represented in this RefSeq results from the use of the CUG start codon; it is the longest isoform.
      Source sequence(s)
      AK041046, BC076605
      UniProtKB/Swiss-Prot
      Q99MD6
      Conserved Domains (4) summary
      cd03419
      Location:76157
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
      TIGR01438
      Location:164652
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:347421
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:524634
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    2. NM_001178059.1NP_001171530.1  thioredoxin reductase 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two consecutive in-frame coding exons compared to variant 1. It contains two in-frame translation initiation codons: an upstream non-AUG (CUG) and a downstream AUG codon. The isoform (3) represented in this RefSeq results from the use of the CUG start codon. It lacks an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK041046, AK134987
      UniProtKB/TrEMBL
      Q3UY43
      Conserved Domains (3) summary
      cd03419
      Location:76157
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
      TIGR01438
      Location:164538
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam02852
      Location:410520
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    3. NM_001178060.1NP_001171531.1  thioredoxin reductase 3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two consecutive in-frame coding exons compared to variant 1. It contains two in-frame translation initiation codons: an upstream non-AUG (CUG) and a downstream AUG codon. The isoform (4) represented in this RefSeq results from the use of the AUG start codon. It has a shorter N-terminus and lacks an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK041046, AK134987
      Consensus CDS
      CCDS57437.1
      UniProtKB/TrEMBL
      Q3UY43
      Related
      ENSMUSP00000098730.1, OTTMUSP00000023391, ENSMUST00000101171.1, OTTMUST00000050186
      Conserved Domains (3) summary
      cd03419
      Location:39120
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
      TIGR01438
      Location:127501
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam02852
      Location:373483
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    4. NM_153162.3NP_694802.2  thioredoxin reductase 3 isoform 2

      See identical proteins and their annotated locations for NP_694802.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant and longer transcript. It contains two in-frame translation initiation codons: an upstream non-AUG (CUG) and a downstream AUG codon. The isoform (2, also known as TGR) represented in this RefSeq results from the use of the AUG start codon. It has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK041046, BC076605
      Consensus CDS
      CCDS57436.1
      UniProtKB/Swiss-Prot
      Q99MD6
      Related
      ENSMUSP00000000828.6, OTTMUSP00000023390, ENSMUST00000000828.12, OTTMUST00000050185
      Conserved Domains (4) summary
      cd03419
      Location:39120
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
      TIGR01438
      Location:127615
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:310384
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:487597
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      89643988..89675529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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