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    JKAMP JNK1/MAPK8-associated membrane protein [ Homo sapiens (human) ]

    Gene ID: 51528, updated on 9-Jul-2017
    Official Symbol
    JKAMPprovided by HGNC
    Official Full Name
    JNK1/MAPK8-associated membrane proteinprovided by HGNC
    Primary source
    HGNC:HGNC:20184
    See related
    Ensembl:ENSG00000050130 MIM:611176; Vega:OTTHUMG00000171054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JAMP; CDA06; HSPC213; HSPC327; C14orf100; C24orf100
    Orthologs
    Location:
    14q23.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (59484443..59505407)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (59951161..59972081)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 135 Neighboring gene trans-L-3-hydroxyproline dehydratase Neighboring gene coiled-coil domain containing 175 Neighboring gene reticulon 1 Neighboring gene microRNA 5586 Neighboring gene uncharacterized LOC105370524 Neighboring gene leucine rich repeat containing 9

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ46787

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent ERAD pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    JNK1/MAPK8-associated membrane protein
    Names
    JNK-associated membrane protein
    Jun N-terminal kinase 1-associated membrane protein
    medulloblastoma antigen MU-MB-50.4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098625.2NP_001092095.1  JNK1/MAPK8-associated membrane protein isoform 2

      See identical proteins and their annotated locations for NP_001092095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL121694, BC005198, BX161501, DC381037, HY340214
      Consensus CDS
      CCDS45117.1
      UniProtKB/Swiss-Prot
      Q9P055
      Related
      ENSP00000389699.2, OTTHUMP00000244974, ENST00000425728.6, OTTHUMT00000411433
      Conserved Domains (1) summary
      pfam05571
      Location:3294
      DUF766; Protein of unknown function (DUF766)
    2. NM_001284201.1NP_001271130.1  JNK1/MAPK8-associated membrane protein isoform 3

      See identical proteins and their annotated locations for NP_001271130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK056145, AL121694, BX161501, DC381037, HY340214
      Consensus CDS
      CCDS61462.1
      UniProtKB/Swiss-Prot
      Q9P055
      UniProtKB/TrEMBL
      B3KPC2, G3V2M4
      Related
      ENSP00000450749.1, OTTHUMP00000244977, ENST00000554271.5, OTTHUMT00000411437
      Conserved Domains (1) summary
      pfam05571
      Location:23314
      DUF766; Protein of unknown function (DUF766)
    3. NM_001284202.1NP_001271131.1  JNK1/MAPK8-associated membrane protein isoform 4

      See identical proteins and their annotated locations for NP_001271131.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon and uses an alternate in-frame splice in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL121694, BX161501, DC381037, HY340214
      Consensus CDS
      CCDS61463.1
      UniProtKB/Swiss-Prot
      Q9P055
      Related
      ENSP00000348351.5, ENST00000356057.9
      Conserved Domains (1) summary
      pfam05571
      Location:17308
      DUF766; Protein of unknown function (DUF766)
    4. NM_001284203.1NP_001271132.1  JNK1/MAPK8-associated membrane protein isoform 5

      See identical proteins and their annotated locations for NP_001271132.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK298209, AL121694, BX161501, DC381037, HY340214
      UniProtKB/Swiss-Prot
      Q9P055
      UniProtKB/TrEMBL
      A0A024R666
      Conserved Domains (1) summary
      pfam05571
      Location:1237
      DUF766; Protein of unknown function (DUF766)
    5. NM_001284204.1NP_001271133.1  JNK1/MAPK8-associated membrane protein isoform 6

      See identical proteins and their annotated locations for NP_001271133.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (6) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AF212245, AL121694, BU928810, BX161501, DC381037, HY340214
      UniProtKB/Swiss-Prot
      Q9P055
      UniProtKB/TrEMBL
      A0A087WVY6
      Related
      ENSP00000479775.1, ENST00000616435.4
      Conserved Domains (1) summary
      pfam05571
      Location:9213
      DUF766; Protein of unknown function (DUF766)
    6. NM_016475.4NP_057559.2  JNK1/MAPK8-associated membrane protein isoform 1

      See identical proteins and their annotated locations for NP_057559.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL121694, AL136696, BX161501, DC381037, HY340214
      Consensus CDS
      CCDS45116.1
      UniProtKB/Swiss-Prot
      Q9P055
      Related
      ENSP00000261247.9, OTTHUMP00000244973, ENST00000261247.13, OTTHUMT00000411430
      Conserved Domains (1) summary
      pfam05571
      Location:9300
      DUF766; Protein of unknown function (DUF766)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      59484443..59505407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021366.1XP_016876855.1  JNK1/MAPK8-associated membrane protein isoform X2

    2. XM_006720171.3XP_006720234.1  JNK1/MAPK8-associated membrane protein isoform X1

      Related
      ENSP00000450813.1, OTTHUMP00000244978, ENST00000554795.1, OTTHUMT00000411438
      Conserved Domains (1) summary
      pfam05571
      Location:23227
      DUF766; Protein of unknown function (DUF766)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      59889332..59910305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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