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    B4GAT1 beta-1,4-glucuronyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 11041, updated on 25-May-2017
    Official Symbol
    B4GAT1provided by HGNC
    Official Full Name
    beta-1,4-glucuronyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:15685
    See related
    Ensembl:ENSG00000174684 MIM:605517; Vega:OTTHUMG00000167082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    iGAT; iGNT; B3GNT1; B3GNT6; B3GN-T1; MDDGA13; BETA3GNTI
    Summary
    This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11q13.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (66345372..66347690, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66112843..66115161, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 1 Neighboring gene breast cancer metastasis suppressor 1 Neighboring gene uncharacterized LOC102724064 Neighboring gene transfer RNA-Ser (GCT) 3-1 Neighboring gene solute carrier family 29 member 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) in cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
      Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
    • Keratan sulfate biosynthesis, organism-specific biosystem (from REACTOME)
      Keratan sulfate biosynthesis, organism-specific biosystemKeratan sulfate (KSI) is the best characterised keratan sulfate. It is 10 times more abundant in cornea than cartilage. KSI is attached to an asparagine (Asn) residue on the core protein via an N-lin...
    • Keratan sulfate/keratin metabolism, organism-specific biosystem (from REACTOME)
      Keratan sulfate/keratin metabolism, organism-specific biosystemKeratan sulfate (KS) (a glycosaminoglycan, GAG) is a linear polysaccharide that consists of the repeating disaccharide unit GlcNAc-Gal (N-acetylglucosamine-galactose). KS can perform a structural fun...
    • Mannose type O-glycan biosynthesis, organism-specific biosystem (from KEGG)
      Mannose type O-glycan biosynthesis, organism-specific biosystemBiosynthesis of mammalian O-mannosyl glycans is initiated by the transfer of mannose from mannose-P-Dol to serine or threonine residue, followed by extensions with N-acetylglucosamine (GlcNAc) and ga...
    • Mannose type O-glycan biosynthesis, conserved biosystem (from KEGG)
      Mannose type O-glycan biosynthesis, conserved biosystemBiosynthesis of mammalian O-mannosyl glycans is initiated by the transfer of mannose from mannose-P-Dol to serine or threonine residue, followed by extensions with N-acetylglucosamine (GlcNAc) and ga...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
      Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • O-linked glycosylation, organism-specific biosystem (from REACTOME)
      O-linked glycosylation, organism-specific biosystemO-glycosylation is an important post-translational modification (PTM) required for correct functioning of many proteins (Van den Steen et al. 1998, Moremen et al. 2012). The O-glycosylation of protei...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • terminal O-glycans residues modification, organism-specific biosystem (from BIOCYC)
      terminal O-glycans residues modification, organism-specific biosystemEnzymatic glycosylation of proteins and lipids is an abundant and important biological process. A great diversity of oligosaccharide structures and types of glycoconjugates is found in nature, and th...
    • terminal O-glycans residues modification, conserved biosystem (from BIOCYC)
      terminal O-glycans residues modification, conserved biosystemEnzymatic glycosylation of proteins and lipids is an abundant and important biological process. A great diversity of oligosaccharide structures and types of glycoconjugates is found in nature, and th...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    keratan sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
     
    poly-N-acetyllactosamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT poly-N-acetyllactosamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein O-linked glycosylation TAS
    Traceable Author Statement
    more info
     
    protein O-linked mannosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of Golgi membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    beta-1,4-glucuronyltransferase 1
    Names
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
    beta-1,3-N-acetylglucosaminyltransferase bGnT-6
    i-beta-1,3-N-acetylglucosaminyltransferase
    poly-N-acetyllactosamine extension enzyme
    NP_006867.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033202.1 RefSeqGene

      Range
      5001..7319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006876.2NP_006867.1  beta-1,4-glucuronyltransferase 1

      See identical proteins and their annotated locations for NP_006867.1

      Status: REVIEWED

      Source sequence(s)
      AF029893, DA169103
      Consensus CDS
      CCDS8136.1
      UniProtKB/Swiss-Prot
      O43505
      UniProtKB/TrEMBL
      A0A024R5F9
      Related
      ENSP00000309096.4, OTTHUMP00000235058, ENST00000311181.4, OTTHUMT00000392959
      Conserved Domains (1) summary
      pfam13896
      Location:94408
      Glyco_transf_49; Glycosyl-transferase for dystroglycan

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      66345372..66347690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      65996963..65999260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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