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    Chd2 chromodomain helicase DNA binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 244059, updated on 22-Apr-2017
    Official Symbol
    Chd2provided by MGI
    Official Full Name
    chromodomain helicase DNA binding protein 2provided by MGI
    Primary source
    MGI:MGI:2448567
    See related
    Ensembl:ENSMUSG00000078671 Vega:OTTMUSG00000036993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CHD-2; AI851092; BC029703; 2810013C04Rik; 2810040A01Rik; 5630401D06Rik
    Orthologs
    Location:
    7; 7 D1
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (73426652..73541746, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (80571538..80686632, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730056A06 gene Neighboring gene uncharacterized LOC100505025 Neighboring gene repulsive guidance molecule family member A Neighboring gene RIKEN cDNA 1810026B05 gene Neighboring gene predicted gene, 30149 Neighboring gene predicted gene, 39036 Neighboring gene predicted gene 7710

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    chromodomain-helicase-DNA-binding protein 2
    Names
    ATP-dependent helicase CHD2
    NP_001074814.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081345.2NP_001074814.2  chromodomain-helicase-DNA-binding protein 2

      See identical proteins and their annotated locations for NP_001074814.2

      Status: VALIDATED

      Source sequence(s)
      AC099699, AC154883
      Consensus CDS
      CCDS52274.1
      UniProtKB/Swiss-Prot
      E9PZM4
      Related
      ENSMUSP00000126352.2, OTTMUSP00000053039, ENSMUST00000169922.8, OTTMUST00000095121
      Conserved Domains (7) summary
      cd00024
      Location:282344
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:503648
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:487768
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:790905
      Helicase_C; Helicase conserved C-terminal domain
      pfam00385
      Location:379447
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      pfam13907
      Location:14711553
      DUF4208; Domain of unknown function (DUF4208)
      pfam17104
      Location:10421165
      DUF5102; Domain of unknown function (DUF5102)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      73426652..73541746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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