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    Spon2 spondin 2, extracellular matrix protein [ Mus musculus (house mouse) ]

    Gene ID: 100689, updated on 30-Apr-2017
    Official Symbol
    Spon2provided by MGI
    Official Full Name
    spondin 2, extracellular matrix proteinprovided by MGI
    Primary source
    MGI:MGI:1923724
    See related
    Ensembl:ENSMUSG00000037379 Vega:OTTMUSG00000055359
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mindin; AI504350; Mspondin; M-spondin; 2310045I24Rik
    Orthologs
    Location:
    5; 5 B1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (33213518..33218254, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (33556167..33560887, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35A, pseudogene 5 Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 1 Neighboring gene C-terminal binding protein 1 Neighboring gene predicted gene 20465

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antigen binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    induction of bacterial agglutination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mast cell mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    opsonization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    opsonization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of macrophage cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of macrophage cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteinaceous extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133903.3NP_598664.3  spondin-2 precursor

      See identical proteins and their annotated locations for NP_598664.3

      Status: VALIDATED

      Source sequence(s)
      AC115070, AK028987, BB848417
      Consensus CDS
      CCDS19200.1
      UniProtKB/Swiss-Prot
      Q8BMS2
      Related
      ENSMUSP00000042701.4, OTTMUSP00000072231, ENSMUST00000046186.7, OTTMUST00000137051
      Conserved Domains (2) summary
      smart00209
      Location:279329
      TSP1; Thrombospondin type 1 repeats
      pfam06468
      Location:40227
      Spond_N; Spondin_N

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      33213518..33218254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503622.2XP_006503685.1  spondin-2 isoform X1

      See identical proteins and their annotated locations for XP_006503685.1

      UniProtKB/Swiss-Prot
      Q8BMS2
      Conserved Domains (2) summary
      smart00209
      Location:279329
      TSP1; Thrombospondin type 1 repeats
      pfam06468
      Location:40227
      Spond_N; Spondin_N
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