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    MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [ Homo sapiens (human) ]

    Gene ID: 9448, updated on 8-Apr-2018
    Official Symbol
    MAP4K4provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:6866
    See related
    Ensembl:ENSG00000071054 MIM:604666; Vega:OTTHUMG00000155394
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HGK; NIK; MEKKK4; FLH21957; HEL-S-31
    Summary
    The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 42.7), fat (RPKM 25.1) and 23 other tissues See more
    Orthologs
    Location:
    2q11.2
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (101697703..101894690)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102314165..102511152)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene prolylcarboxypeptidase (angiotensinase C) pseudogene Neighboring gene uncharacterized LOC105373514 Neighboring gene long intergenic non-protein coding RNA 1127 Neighboring gene interleukin 1 receptor type 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    NHGRI GWA Catalog
    • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
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    • Cellular Senescence, organism-specific biosystem (from REACTOME)
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    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Ceramide signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Ceramide signaling pathway, organism-specific biosystem
      Ceramide signaling pathway
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHB forward signaling, organism-specific biosystem
      EPHB forward signaling
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Oxidative Stress Induced Senescence, organism-specific biosystem (from REACTOME)
      Oxidative Stress Induced Senescence, organism-specific biosystemOxidative stress, caused by increased concentration of reactive oxygen species (ROS) in the cell, can happen as a consequence of mitochondrial dysfunction induced by the oncogenic RAS (Moiseeva et al...
    • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TNF receptor signaling pathway, organism-specific biosystem
      TNF receptor signaling pathway
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ10410, FLJ20373, FLJ90111, KIAA0687

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    creatine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPKKK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron projection regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signal transduction by protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    stress-activated protein kinase signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 4
    Names
    HPK/GCK-like kinase HGK
    MAPK/ERK kinase kinase kinase 4
    MEK kinase kinase 4
    Ste20 group protein kinase HGK
    epididymis secretory protein Li 31
    hepatocyte progenitor kinase-like/germinal center kinase-like kinase
    nck-interacting kinase
    NP_001229488.1
    NP_001229489.1
    NP_004825.3
    NP_663719.2
    NP_663720.1
    XP_005264105.1
    XP_005264107.1
    XP_005264109.1
    XP_005264114.1
    XP_005264115.1
    XP_005264116.1
    XP_005264117.1
    XP_005264119.1
    XP_005264120.1
    XP_005264121.1
    XP_005264122.1
    XP_005264123.1
    XP_005264125.1
    XP_005264126.1
    XP_005264128.1
    XP_006712928.1
    XP_006712931.1
    XP_006712932.1
    XP_016860838.1
    XP_016860839.1
    XP_016860840.1
    XP_016860841.1
    XP_016860842.1
    XP_016860843.1
    XP_016860844.1
    XP_016860845.1
    XP_016860846.1
    XP_016860847.1
    XP_016860848.1
    XP_016860849.1
    XP_016860850.1
    XP_016860851.1
    XP_016860852.1
    XP_016860853.1
    XP_016860854.1
    XP_016860855.1
    XP_016860856.1
    XP_016860857.1
    XP_016860858.1
    XP_016860859.1
    XP_016860860.1
    XP_016860861.1
    XP_016860862.1
    XP_016860863.1
    XP_016860864.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242559.1NP_001229488.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

      See identical proteins and their annotated locations for NP_001229488.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses two alternate in-frame splice sites and lacks an alternate in-frame exon in the central coding region, compared to variant 2. The encoded isoform (4) is shorter than isoform 2. The 5' UTR of this variant is incomplete due to a lack of 5'-complete transcripts representing this variant, and the presence of splicing ambiguity in the 5' UTR.
      Source sequence(s)
      AC005035, AY212247, BU625485, DB086475
      Consensus CDS
      CCDS56130.1
      UniProtKB/Swiss-Prot
      O95819
      Related
      ENSP00000314363.6, OTTHUMP00000207903, ENST00000347699.8, OTTHUMT00000339839
      Conserved Domains (2) summary
      smart00036
      Location:9211219
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001242560.1NP_001229489.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons but includes two different alternate in-frame exons in the central coding region, compared to variant 2. The encoded isoform (5) is shorter than isoform 2.
      Source sequence(s)
      AC005035, AC007005, AK296396, BU625485, DR002278
      UniProtKB/TrEMBL
      B7Z3V5
      Related
      ENSP00000313644.5, ENST00000324219.8
      Conserved Domains (3) summary
      smart00036
      Location:9171215
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    3. NM_004834.4NP_004825.3  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

      See identical proteins and their annotated locations for NP_004825.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks two alternate in-frame exons but includes a different in-frame exon in the central coding region, and uses an alternate in-frame splice site in both the central and 3' coding regions, compared to variant 2. The encoded isoform (1) is shorter than isoform 2.
      Source sequence(s)
      AC005035, AC007005, AF096300, BU625485, DR002278
      Consensus CDS
      CCDS82487.1
      UniProtKB/Swiss-Prot
      O95819
      Related
      ENSP00000489579.1, OTTHUMP00000281202, ENST00000634702.1, OTTHUMT00000488049
      Conserved Domains (2) summary
      smart00036
      Location:8391145
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
    4. NM_145686.3NP_663719.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

      See identical proteins and their annotated locations for NP_663719.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AC005035, AC007005, BC064691, BU625485, DR002278
      Consensus CDS
      CCDS74546.1
      UniProtKB/Swiss-Prot
      O95819
      Related
      ENSP00000343658.5, ENST00000350878.8
      Conserved Domains (2) summary
      smart00036
      Location:9551253
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    5. NM_145687.3NP_663720.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 3

      See identical proteins and their annotated locations for NP_663720.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon but includes a different in-frame exon in the central coding region, compared to variant 2. The encoded isoform (3) is shorter than isoform 2. The 5' UTR of this variant is incomplete due to a lack of 5'-complete transcripts representing this variant, and the presence of splicing ambiguity in the 5' UTR.
      Source sequence(s)
      AB014587, AC005035, BU625485, DB086475
      UniProtKB/Swiss-Prot
      O95819
      UniProtKB/TrEMBL
      V9HWH3
      Conserved Domains (3) summary
      smart00036
      Location:8941192
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      101697703..101894690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264048.2XP_005264105.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

      Conserved Domains (3) summary
      smart00036
      Location:10661364
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    2. XM_005264057.3XP_005264114.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X6

      Conserved Domains (3) summary
      smart00036
      Location:9891295
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    3. XM_017005352.1XP_016860841.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X9

    4. XM_017005365.1XP_016860854.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X28

    5. XM_005264058.3XP_005264115.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X7

      Conserved Domains (3) summary
      smart00036
      Location:9861292
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    6. XM_017005353.1XP_016860842.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X11

    7. XM_017005351.1XP_016860840.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X8

    8. XM_005264050.3XP_005264107.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X3

      Conserved Domains (3) summary
      smart00036
      Location:10121318
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    9. XM_017005350.1XP_016860839.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X5

    10. XM_017005359.1XP_016860848.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X19

    11. XM_017005361.1XP_016860850.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X21

      Related
      ENSP00000486116.1, ENST00000625522.2
    12. XM_005264052.3XP_005264109.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X4

      Conserved Domains (3) summary
      smart00036
      Location:10111317
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    13. XM_017005360.1XP_016860849.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X20

    14. XM_017005362.1XP_016860851.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X22

    15. XM_005264062.3XP_005264119.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X23

      Conserved Domains (3) summary
      smart00036
      Location:9351241
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    16. XM_017005363.1XP_016860852.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X26

    17. XM_006712869.2XP_006712932.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X37

      Related
      ENSP00000303600.6, ENST00000302217.9
      Conserved Domains (3) summary
      smart00036
      Location:8711169
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
    18. XM_005264064.3XP_005264121.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X25

      Conserved Domains (3) summary
      smart00036
      Location:9321238
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    19. XM_017005371.1XP_016860860.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X39

      Related
      ENSP00000487176.1, ENST00000627726.2
    20. XM_005264063.3XP_005264120.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X24

      Conserved Domains (3) summary
      smart00036
      Location:9341240
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    21. XM_017005369.1XP_016860858.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X36

    22. XM_017005370.1XP_016860859.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X38

    23. XM_017005364.1XP_016860853.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X27

    24. XM_005264071.2XP_005264128.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X40

      Related
      ENSP00000387370.1, OTTHUMP00000207973, ENST00000456652.5, OTTHUMT00000339994
      Conserved Domains (3) summary
      smart00036
      Location:8671165
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
    25. XM_017005349.1XP_016860838.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X2

    26. XM_005264059.3XP_005264116.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X14

      Conserved Domains (3) summary
      smart00036
      Location:9581264
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    27. XM_017005357.1XP_016860846.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X17

    28. XM_017005356.1XP_016860845.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X15

    29. XM_005264069.2XP_005264126.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X35

      Related
      ENSP00000409720.1, OTTHUMP00000207972, ENST00000417294.5, OTTHUMT00000339993
      Conserved Domains (3) summary
      smart00036
      Location:8911189
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    30. XM_017005358.1XP_016860847.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X18

    31. XM_017005368.1XP_016860857.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X34

    32. XM_005264060.3XP_005264117.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X16

      Conserved Domains (3) summary
      smart00036
      Location:9541260
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    33. XM_006712865.2XP_006712928.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X10

      Conserved Domains (3) summary
      smart00036
      Location:9811287
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    34. XM_017005354.1XP_016860843.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X12

    35. XM_017005366.1XP_016860855.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X29

    36. XM_017005355.1XP_016860844.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X13

    37. XM_017005367.1XP_016860856.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X30

    38. XM_005264065.3XP_005264122.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X31

      Conserved Domains (3) summary
      smart00036
      Location:9041210
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    39. XM_006712868.2XP_006712931.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X45

      Conserved Domains (3) summary
      smart00036
      Location:9041202
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
    40. XM_017005372.1XP_016860861.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X41

    41. XM_017005374.1XP_016860863.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X43

    42. XM_005264068.3XP_005264125.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X33

      Conserved Domains (3) summary
      smart00036
      Location:9011207
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
    43. XM_017005373.1XP_016860862.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X42

    44. XM_017005375.1XP_016860864.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X44

      Related
      ENSP00000389752.1, OTTHUMP00000207971, ENST00000413150.6, OTTHUMT00000339992
    45. XM_005264066.3XP_005264123.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X32

      Conserved Domains (3) summary
      smart00036
      Location:9031209
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8289
      PKc_like; Protein Kinases, catalytic domain
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