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    FBXW5 F-box and WD repeat domain containing 5 [ Homo sapiens (human) ]

    Gene ID: 54461, updated on 12-Mar-2017
    Official Symbol
    FBXW5provided by HGNC
    Official Full Name
    F-box and WD repeat domain containing 5provided by HGNC
    Primary source
    HGNC:HGNC:13613
    See related
    Ensembl:ENSG00000159069 MIM:609072; Vega:OTTHUMG00000020967
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fbw5
    Summary
    This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    9q34.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (136940433..136944774, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139834885..139839298, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376326 Neighboring gene TNF receptor associated factor 2 Neighboring gene microRNA 4479 Neighboring gene complement C8 gamma chain Neighboring gene lipocalin 12

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC20962, DKFZp434B205

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Cul4-RING E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    F-box/WD repeat-containing protein 5
    Names
    F-box and WD-40 domain-containing protein 5
    WD repeat-containing F-box protein FBW5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018998.3NP_061871.1  F-box/WD repeat-containing protein 5

      See identical proteins and their annotated locations for NP_061871.1

      Status: REVIEWED

      Source sequence(s)
      BC014130, CF132404, DB460097, EC577580
      Consensus CDS
      CCDS7014.1
      UniProtKB/Swiss-Prot
      Q969U6
      UniProtKB/TrEMBL
      A0A024R8H7
      Related
      ENSP00000313034, OTTHUMP00000022659, ENST00000325285, OTTHUMT00000055227
      Conserved Domains (5) summary
      smart00320
      Location:85120
      WD40; WD40 repeats
      COG2319
      Location:395538
      WD40; WD40 repeat [General function prediction only]
      pfam12937
      Location:952
      F-box-like; F-box-like
      sd00039
      Location:419461
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:447538
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      136940433..136944774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014812.1XP_016870301.1  F-box/WD repeat-containing protein 5 isoform X3

    2. XM_011518789.1XP_011517091.1  F-box/WD repeat-containing protein 5 isoform X2

      Conserved Domains (5) summary
      smart00320
      Location:85117
      WD40; WD40 repeats
      COG2319
      Location:387530
      WD40; WD40 repeat [General function prediction only]
      pfam12937
      Location:952
      F-box-like; F-box-like
      sd00039
      Location:411453
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:439530
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_005266089.2XP_005266146.2  F-box/WD repeat-containing protein 5 isoform X1

      Conserved Domains (5) summary
      smart00320
      Location:85117
      WD40; WD40 repeats
      COG2319
      Location:405548
      WD40; WD40 repeat [General function prediction only]
      pfam12937
      Location:952
      F-box-like; F-box-like
      sd00039
      Location:429471
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:457548
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_929811.1 RNA Sequence

      Related
      ENST00000483559
    2. XR_001746323.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      139983564..139987884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178225.1: Suppressed sequence

      Description
      NM_178225.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_178226.1: Suppressed sequence

      Description
      NM_178226.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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