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    Akap1 A-kinase anchoring protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114124, updated on 22-Jun-2017
    Official Symbol
    Akap1provided by RGD
    Official Full Name
    A-kinase anchoring protein 1provided by RGD
    Primary source
    RGD:620826
    See related
    Ensembl:ENSRNOG00000002373
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akap84
    Summary
    scaffolding protein that immobilizes and concentrates protein kinase A II (PKAII) isoforms at specific intracellular locations [RGD, Feb 2006]
    Orthologs
    Location:
    10q26
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (76151013..76183987, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (73927523..73960524)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene protein TIME FOR COFFEE-like Neighboring gene uncharacterized LOC108352117 Neighboring gene hypothetical LOC303431 Neighboring gene serine carboxypeptidase 1 Neighboring gene uncharacterized LOC102557601

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein domain specific binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase A regulatory subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase A regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphatase 2B binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphatase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to peptide hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of NFAT protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein kinase A signaling IC
    Inferred by Curator
    more info
    PubMed 
    regulation of protein kinase A signaling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial crista IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    A-kinase anchor protein 1, mitochondrial
    Names
    A kinase (PRKA) anchor protein 1
    A-kinase anchor protein 121 kDa
    AKAP 121
    D-AKAP-1
    PRKA1
    S-AKAP84
    a kinase anchor protein 1, mitochondrial
    dual specificity A-kinase-anchoring protein 1
    protein kinase A-anchoring protein 1
    spermatid A-kinase anchor protein 84

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053665.1NP_446117.1  A-kinase anchor protein 1, mitochondrial

      See identical proteins and their annotated locations for NP_446117.1

      Status: PROVISIONAL

      Source sequence(s)
      AF068202
      UniProtKB/Swiss-Prot
      O88884
      Related
      ENSRNOP00000052543.3, ENSRNOT00000055683.5
      Conserved Domains (4) summary
      smart00333
      Location:707765
      TUDOR; Tudor domain
      cd00105
      Location:562622
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:655777
      TUDOR; Tudor domain
      pfam04814
      Location:394510
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      76151013..76183987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247068.1XP_006247130.1  A-kinase anchor protein 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006247130.1

      UniProtKB/TrEMBL
      D4A9M6
      Conserved Domains (4) summary
      smart00333
      Location:707765
      TUDOR; Tudor domain
      cd00105
      Location:562622
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:655777
      TUDOR; Tudor domain
      pfam04814
      Location:394510
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    2. XM_006247067.3XP_006247129.1  A-kinase anchor protein 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006247129.1

      UniProtKB/TrEMBL
      D4A9M6
      Conserved Domains (4) summary
      smart00333
      Location:707765
      TUDOR; Tudor domain
      cd00105
      Location:562622
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:655777
      TUDOR; Tudor domain
      pfam04814
      Location:394510
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    3. XM_008767930.1XP_008766152.1  A-kinase anchor protein 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_008766152.1

      UniProtKB/TrEMBL
      D4A9M6
      Conserved Domains (4) summary
      smart00333
      Location:707765
      TUDOR; Tudor domain
      cd00105
      Location:562622
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:655777
      TUDOR; Tudor domain
      pfam04814
      Location:394510
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      72528421..72542825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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