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    Recql5 RecQ protein-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 170472, updated on 22-Apr-2017
    Official Symbol
    Recql5provided by MGI
    Official Full Name
    RecQ protein-like 5provided by MGI
    Primary source
    MGI:MGI:2156841
    See related
    Ensembl:ENSMUSG00000020752 Vega:OTTMUSG00000003617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RecQ5; Recq5b; Recql5b
    Orthologs
    Location:
    11; 11 E2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (115892595..115933534, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115753991..115794320, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene lethal giant larvae homolog 2 (Drosophila) Neighboring gene myosin XVB Neighboring gene small integral membrane protein 5 Neighboring gene small integral membrane protein 6 Neighboring gene SAP30 binding protein Neighboring gene predicted gene, 39474 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene integrin beta 4

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ATP-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core binding ISO
    Inferred from Sequence Orthology
    more info
     
    four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to camptothecin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to camptothecin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to drug IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of double-strand break repair via homologous recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    replication-born double-strand break repair via sister chromatid exchange IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    DNA-directed RNA polymerase II, holoenzyme ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ATP-dependent DNA helicase Q5
    Names
    DNA helicase, RecQ-like type 5
    RECQL5beta
    NP_569721.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130454.2NP_569721.1  ATP-dependent DNA helicase Q5

      See identical proteins and their annotated locations for NP_569721.1

      Status: VALIDATED

      Source sequence(s)
      AK049269, AL645647, AW049927, BC059000
      Consensus CDS
      CCDS25650.1
      UniProtKB/Swiss-Prot
      Q8VID5
      Related
      ENSMUSP00000021097.3, OTTMUSP00000003793, ENSMUST00000021097.9, OTTMUST00000007806
      Conserved Domains (5) summary
      smart00487
      Location:22229
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:258363
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:31201
      DEAD; DEAD/DEAH box helicase
      pfam06959
      Location:626817
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:368435
      RecQ_Zn_bind; RecQ zinc-binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      115892595..115933534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532361.3XP_006532424.1  ATP-dependent DNA helicase Q5 isoform X4

      See identical proteins and their annotated locations for XP_006532424.1

      Conserved Domains (3) summary
      cd00079
      Location:257
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam06959
      Location:320508
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:62129
      RecQ_Zn_bind; RecQ zinc-binding
    2. XM_006532359.3XP_006532422.1  ATP-dependent DNA helicase Q5 isoform X2

      Conserved Domains (5) summary
      COG0514
      Location:6398
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      cd00079
      Location:217322
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:5160
      DEAD; DEAD/DEAH box helicase
      pfam06959
      Location:585776
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:327394
      RecQ_Zn_bind; RecQ zinc-binding
    3. XM_006532358.3XP_006532421.1  ATP-dependent DNA helicase Q5 isoform X1

      Conserved Domains (5) summary
      smart00487
      Location:23230
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:259364
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:32202
      DEAD; DEAD/DEAH box helicase
      pfam06959
      Location:627818
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:369436
      RecQ_Zn_bind; RecQ zinc-binding
    4. XM_006532360.3XP_006532423.1  ATP-dependent DNA helicase Q5 isoform X3

      Conserved Domains (4) summary
      COG0514
      Location:17197
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      cd00079
      Location:15121
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam06959
      Location:384572
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:126193
      RecQ_Zn_bind; RecQ zinc-binding
    5. XM_006532363.3XP_006532426.1  ATP-dependent DNA helicase Q5 isoform X6

      Conserved Domains (2) summary
      pfam06959
      Location:231419
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:1740
      RecQ_Zn_bind; RecQ zinc-binding
    6. XM_006532362.3XP_006532425.1  ATP-dependent DNA helicase Q5 isoform X5

      Conserved Domains (2) summary
      pfam06959
      Location:231419
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:1240
      RecQ_Zn_bind; RecQ zinc-binding

    RNA

    1. XR_001779887.1 RNA Sequence

    2. XR_001779886.1 RNA Sequence

    3. XR_001779885.1 RNA Sequence

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