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    Tyro3 TYRO3 protein tyrosine kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 22174, updated on 5-Nov-2017
    Official Symbol
    Tyro3provided by MGI
    Official Full Name
    TYRO3 protein tyrosine kinase 3provided by MGI
    Primary source
    MGI:MGI:104294
    See related
    Ensembl:ENSMUSG00000027298 Vega:OTTMUSG00000016527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brt; Dtk; Rse; Sky; Tif; Etk-2; TK19-2; tk19-1; AI323366; etk2/tyro3
    Orthologs
    Location:
    2 E5; 2 59.97 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (119797740..119818104)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (119625250..119643840)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene leukocyte tyrosine kinase Neighboring gene RNA polymerase II associated protein 1 Neighboring gene fatty acid binding protein 5, epidermal pseudogene Neighboring gene MAX gene associated Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene microRNA 7665

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic cell clearance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    natural killer cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of innate immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of lymphocyte activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of toll-like receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuropeptide signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovulation cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase B signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    secretion by cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vagina development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    tyrosine-protein kinase receptor TYRO3
    Names
    receptor tyrosine kinase
    tyrosine kinase growth factor receptor isoform III
    tyrosine-protein kinase DTK
    tyrosine-protein kinase RSE
    tyrosine-protein kinase TIF
    NP_001277729.1
    NP_062265.2
    XP_006499223.1
    XP_017172636.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290800.1NP_001277729.1  tyrosine-protein kinase receptor TYRO3 isoform B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternative 5' exon structure, and it thus differs in its 5' UTR and initiates translation from an alternative start codon, compared to variant 1. The encoded isoform (B) has a distinct N-terminus and is shorter than isoform A.
      Source sequence(s)
      AL844896, BC066058
      Consensus CDS
      CCDS71119.1
      UniProtKB/Swiss-Prot
      P55144
      Related
      ENSMUSP00000106410.1, OTTMUSP00000017809, ENSMUST00000110783.7, OTTMUST00000039942
      Conserved Domains (7) summary
      smart00408
      Location:42107
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:35121
      IG_like; Immunoglobulin like
      cd00063
      Location:211303
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05074
      Location:494777
      PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
      pfam00041
      Location:311392
      fn3; Fibronectin type III domain
      pfam07714
      Location:504772
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:127205
      Ig; Immunoglobulin domain
    2. NM_019392.2NP_062265.2  tyrosine-protein kinase receptor TYRO3 isoform A precursor

      See identical proteins and their annotated locations for NP_062265.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (A).
      Source sequence(s)
      BC066058
      Consensus CDS
      CCDS16611.1
      UniProtKB/Swiss-Prot
      P55144
      Related
      ENSMUSP00000028763.9, OTTMUSP00000017810, ENSMUST00000028763.9, OTTMUST00000039943
      Conserved Domains (7) summary
      smart00408
      Location:46111
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:39125
      IG_like; Immunoglobulin like
      cd00063
      Location:215307
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05074
      Location:498781
      PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
      pfam00041
      Location:315396
      fn3; Fibronectin type III domain
      pfam07714
      Location:508776
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:131209
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      119797740..119818104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317147.1XP_017172636.1  tyrosine-protein kinase receptor TYRO3 isoform X1

      UniProtKB/Swiss-Prot
      P55144
    2. XM_006499160.1XP_006499223.1  tyrosine-protein kinase receptor TYRO3 isoform X2

      Conserved Domains (7) summary
      smart00408
      Location:1176
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:490
      IG_like; Immunoglobulin like
      cd00063
      Location:180272
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05074
      Location:463746
      PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
      pfam00041
      Location:280361
      fn3; Fibronectin type III domain
      pfam07714
      Location:473741
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:96174
      Ig; Immunoglobulin domain
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