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    Egr1 early growth response 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24330, updated on 12-Nov-2017
    Official Symbol
    Egr1provided by RGD
    Official Full Name
    early growth response 1provided by RGD
    Primary source
    RGD:2544
    See related
    Ensembl:ENSRNOG00000019422
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ngf1; Ngfi; NGFI-A; Krox-24; zif-268
    Summary
    activates transcription of the LH receptor gene; may be involved in synaptic plasticity during REM sleep [RGD, Feb 2006]
    Orthologs
    Location:
    18p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27657903..27660101)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (27369518..27371716)

    Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene lysine demethylase 3B Neighboring gene receptor accessory protein 2 Neighboring gene uncharacterized LOC102550732 Neighboring gene eukaryotic translation termination factor 1

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
      Ovarian Infertility Genes, organism-specific biosystemOvarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility ph...
    • Prion diseases, organism-specific biosystem (from KEGG)
      Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Prion diseases, conserved biosystem (from KEGG)
      Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process tha...

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded methylated DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded methylated DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hemi-methylated DNA-binding IEA
    Inferred from Electronic Annotation
    more info
     
    hemi-methylated DNA-binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone acetyltransferase binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    promoter-specific chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to follicle-stimulating hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to gonadotropin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to heparin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hyperoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interleukin-8 IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-8 ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to interleukin-8 ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to isoquinoline alkaloid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to mycophenolic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to organic substance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to steroid hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    estrous cycle IEA
    Inferred from Electronic Annotation
    more info
     
    estrous cycle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    estrous cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glomerular mesangial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    learning or memory IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term synaptic potentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oligodendrocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chemokine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of chemokine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glomerular metanephric mesangial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hormone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of hormone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-1 beta biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-1 beta biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of interleukin-1 beta biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tau-protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of progesterone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of progesterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of progesterone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to carbon monoxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cocaine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to follicle-stimulating hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucose ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to gonadotropin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    response to insulin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to ischemia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    response to ischemia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to norepinephrine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    skeletal muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    early growth response protein 1
    Names
    EGR-1
    nerve growth factor-induced protein A
    transcription factor Zif268
    zinc finger protein Krox-24

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012551.2NP_036683.1  early growth response protein 1

      See identical proteins and their annotated locations for NP_036683.1

      Status: PROVISIONAL

      Source sequence(s)
      AY551092
      UniProtKB/Swiss-Prot
      P08154
      Related
      ENSRNOP00000026303.4, ENSRNOT00000026303.4
      Conserved Domains (7) summary
      COG5048
      Location:338396
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:313335
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:311335
      zf-C2H2; Zinc finger, C2H2 type
      pfam05687
      Location:424453
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam11914
      Location:420495
      DUF3432; Domain of unknown function (DUF3432)
      pfam11928
      Location:107182
      DUF3446; Domain of unknown function (DUF3446)
      pfam13465
      Location:355380
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

      Range
      27657903..27660101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000086.1 Alternate Rn_Celera

      Range
      26200028..26202226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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