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    dkk1b dickkopf WNT signaling pathway inhibitor 1b [ Danio rerio (zebrafish) ]

    Gene ID: 30197, updated on 21-Oct-2017
    Official Symbol
    dkk1bprovided by ZNC
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990708-5
    See related
    Ensembl:ENSDARG00000045219 Vega:OTTDARG00000020510
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    dkk1
    Orthologs
    Location:
    chromosome: 12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (6465531..6467675)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (6432066..6434174)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene apobec1 complementation factor Neighboring gene protein kinase, cGMP-dependent, type Ib Neighboring gene protocadherin-related 15b Neighboring gene si:dkey-187i8.2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Canonical wnt signaling, organism-specific biosystem (from WikiPathways)
      Canonical wnt signaling, organism-specific biosystem
      Canonical wnt signaling
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Markers

    Homology

    Clone Names

    • MGC152787

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell dedifferentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ectoderm development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocardial cushion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    forebrain neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatic duct development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    liver development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    notochord development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    posterior lateral line neuromast development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sensory epithelium regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    dickkopf-related protein 1
    Names
    dickkopf 1
    dickkopf 1b
    dickkopf-like protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131003.1NP_571078.1  dickkopf-related protein 1 precursor

      See identical proteins and their annotated locations for NP_571078.1

      Status: PROVISIONAL

      Source sequence(s)
      AF116852
      UniProtKB/TrEMBL
      Q9W6D9
      Related
      ENSDARP00000066476.4, OTTDARP00000021119, ENSDART00000066477.5, OTTDART00000025692
      Conserved Domains (1) summary
      pfam04706
      Location:69116
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      6465531..6467675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172963.3XP_005173020.1  dickkopf-related protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005173020.1

      UniProtKB/TrEMBL
      Q9PWH3
      Related
      ENSDARP00000112296.2, OTTDARP00000021120
      Conserved Domains (1) summary
      pfam04706
      Location:68115
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394830.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      87177..88986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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