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    Pnpt1 polyribonucleotide nucleotidyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 71701, updated on 22-Apr-2017
    Official Symbol
    Pnpt1provided by MGI
    Official Full Name
    polyribonucleotide nucleotidyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1918951
    See related
    Ensembl:ENSMUSG00000020464 Vega:OTTMUSG00000005318
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Old35; PNPase; Pnptl1; 1200003F12Rik
    Orthologs
    Location:
    11; 11 A3.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (29130232..29162010)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (29030751..29061828)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 1 Neighboring gene ribosomal protein SA, pseudogene 5 Neighboring gene protein phosphatase 4 regulatory subunit 3B Neighboring gene cilia and flagella associated protein 36 Neighboring gene fibrillarin pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5'-exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
     
    poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    polyribonucleotide nucleotidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    RNA import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial RNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial RNA 5'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear polyadenylation-dependent mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of miRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    rRNA import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial degradosome ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    polysomal ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    polyribonucleotide nucleotidyltransferase 1, mitochondrial
    Names
    3'-5' RNA exonuclease OLD35
    PNPase 1
    PNPase old-35
    polynucleotide phosphorylase 1
    polynucleotide phosphorylase-like protein
    NP_082145.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027869.1NP_082145.1  polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_082145.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ507387
      Consensus CDS
      CCDS24490.1
      UniProtKB/Swiss-Prot
      Q8K1R3
      Related
      ENSMUSP00000020756.8, OTTMUSP00000005486, ENSMUST00000020756.8, OTTMUST00000011847
      Conserved Domains (6) summary
      smart00316
      Location:679750
      S1; Ribosomal protein S1-like RNA-binding domain
      cd11363
      Location:47273
      RNase_PH_PNPase_1; Polyribonucleotide nucleotidyltransferase, repeat 1
      cd11364
      Location:366596
      RNase_PH_PNPase_2; Polyribonucleotide nucleotidyltransferase, repeat 2
      PRK11824
      Location:47752
      PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional
      pfam03726
      Location:282363
      PNPase; Polyribonucleotide nucleotidyltransferase, RNA binding domain
      cl00098
      Location:605664
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      29130232..29162010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243751.2XP_011242053.1  polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011242053.1

      UniProtKB/Swiss-Prot
      Q8K1R3
      Conserved Domains (6) summary
      smart00316
      Location:679750
      S1; Ribosomal protein S1-like RNA-binding domain
      cd11363
      Location:47273
      RNase_PH_PNPase_1; Polyribonucleotide nucleotidyltransferase, repeat 1
      cd11364
      Location:366596
      RNase_PH_PNPase_2; Polyribonucleotide nucleotidyltransferase, repeat 2
      PRK11824
      Location:47752
      PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional
      pfam03726
      Location:282363
      PNPase; Polyribonucleotide nucleotidyltransferase, RNA binding domain
      cl00098
      Location:605664
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    2. XM_006514813.3XP_006514876.1  polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X2

      Conserved Domains (4) summary
      smart00316
      Location:388459
      S1; Ribosomal protein S1-like RNA-binding domain
      cd11364
      Location:75305
      RNase_PH_PNPase_2; Polyribonucleotide nucleotidyltransferase, repeat 2
      pfam03726
      Location:272
      PNPase; Polyribonucleotide nucleotidyltransferase, RNA binding domain
      cl00098
      Location:314373
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
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