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    ITGAM integrin subunit alpha M [ Homo sapiens (human) ]

    Gene ID: 3684, updated on 4-Feb-2018
    Official Symbol
    ITGAMprovided by HGNC
    Official Full Name
    integrin subunit alpha Mprovided by HGNC
    Primary source
    HGNC:HGNC:6149
    See related
    Ensembl:ENSG00000169896 MIM:120980; Vega:OTTHUMG00000176612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
    Summary
    This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
    Expression
    Biased expression in bone marrow (RPKM 72.3), appendix (RPKM 14.6) and 6 other tissues See more
    Orthologs
    Location:
    16p11.2
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (31259967..31332892)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31271288..31344213)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene PYCARD antisense RNA 1 Neighboring gene PYD and CARD domain containing Neighboring gene tripartite motif containing 72 Neighboring gene pyrin domain containing 1 Neighboring gene integrin subunit alpha X pseudogene Neighboring gene integrin subunit alpha X Neighboring gene integrin subunit alpha D

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Systemic lupus erythematosus 6
    MedGen: C1835919 OMIM: 609939 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
    NHGRI GWA Catalog
    Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
    NHGRI GWA Catalog
    Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
    NHGRI GWA Catalog
    Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
    NHGRI GWA Catalog
    Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
    NHGRI GWA Catalog
    GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
    NHGRI GWA Catalog
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Anti-CD18 monoclonal antibodies completely block cell fusion between HIV-1 infected U-937 cells and MT-4 T cells, indicating participation of CD18, or of the protein complex CD11a-c/CD18, in addition to CD4, in the infection and cytopathic effect of HIV-1 PubMed
    Nef nef HIV-1 Nef interacts with complement receptor 3 (CR3) in a manner that allows CR3 redistribution toward bacterial-induced pseudopods in macrophages PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, alpha M (ITGAM, CR3A) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed

    Go to the HIV-1, Human Interaction Database

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
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    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
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    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
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    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
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    • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
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    • Complement and coagulation cascades, conserved biosystem (from KEGG)
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    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
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    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
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    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
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    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
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    • Phagosome, organism-specific biosystem (from KEGG)
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    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
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    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
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    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Tuberculosis, organism-specific biosystem (from KEGG)
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    • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      amb2 Integrin signaling, organism-specific biosystem
      amb2 Integrin signaling
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC117044

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    complement component C3b binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    amyloid-beta clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell adhesion via plasma-membrane adhesion molecules NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    ectodermal cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    extracellular matrix organization TAS
    Traceable Author Statement
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    microglial cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of dopamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of microglial cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neuron death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neutrophil degranulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of prostaglandin-E synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of superoxide anion generation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of superoxide anion generation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    toll-like receptor 4 signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cell surface HDA PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin alphaM-beta2 complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integrin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    specific granule membrane TAS
    Traceable Author Statement
    more info
     
    tertiary granule membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    integrin alpha-M
    Names
    CD11 antigen-like family member B
    CR-3 alpha chain
    antigen CD11b (p170)
    cell surface glycoprotein MAC-1 subunit alpha
    complement component 3 receptor 3 subunit
    integrin, alpha M (complement component 3 receptor 3 subunit)
    leukocyte adhesion receptor MO1
    macrophage antigen alpha polypeptide
    neutrophil adherence receptor alpha-M subunit

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011719.1 RefSeqGene

      Range
      5001..77926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000632.3NP_000623.2  integrin alpha-M isoform 2 precursor

      See identical proteins and their annotated locations for NP_000623.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal amino acid, compared to isoform 1.
      Source sequence(s)
      AA436312, AC093520, AK057856, BC096348
      Consensus CDS
      CCDS45470.1
      UniProtKB/Swiss-Prot
      P11215
      Related
      ENSP00000287497.8, OTTHUMP00000254640, ENST00000287497.12, OTTHUMT00000432816
      Conserved Domains (4) summary
      smart00191
      Location:516562
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11291143
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:614978
      Integrin_alpha2; Integrin alpha
    2. NM_001145808.1NP_001139280.1  integrin alpha-M isoform 1 precursor

      See identical proteins and their annotated locations for NP_001139280.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC093520, BC096348, BM194233, J03925
      Consensus CDS
      CCDS54004.1
      UniProtKB/Swiss-Prot
      P11215
      Related
      ENSP00000441691.2, OTTHUMP00000254641, ENST00000544665.7, OTTHUMT00000432817
      Conserved Domains (4) summary
      smart00191
      Location:517563
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:11301144
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:615979
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      31259967..31332892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023216.1XP_016878705.1  integrin alpha-M isoform X2

    2. XM_011545851.2XP_011544153.1  integrin alpha-M isoform X3

      Conserved Domains (2) summary
      smart00191
      Location:517563
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    3. XM_006721045.1XP_006721108.1  integrin alpha-M isoform X4

      Conserved Domains (2) summary
      smart00191
      Location:516562
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    4. XM_011545850.2XP_011544152.1  integrin alpha-M isoform X1

      Conserved Domains (4) summary
      smart00191
      Location:455501
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:87262
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:10681082
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:553917
      Integrin_alpha2; Integrin alpha

    RNA

    1. XR_950796.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      32589199..32661884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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