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    Tnk2 tyrosine kinase, non-receptor, 2 [ Mus musculus (house mouse) ]

    Gene ID: 51789, updated on 25-May-2017
    Official Symbol
    Tnk2provided by MGI
    Official Full Name
    tyrosine kinase, non-receptor, 2provided by MGI
    Primary source
    MGI:MGI:1858308
    See related
    Ensembl:ENSMUSG00000022791 Vega:OTTMUSG00000026940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ack; Ack1; Pyk1; Ack-1; Cdgip
    Orthologs
    Location:
    16; 16 B3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (32644099..32683493)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (32644729..32683579)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene SET domain containing 6 pseudogene Neighboring gene transferrin receptor Neighboring gene tyrosine kinase, non-receptor 2, opposite strand Neighboring gene predicted gene, 34766 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
    • Oxidative Damage, organism-specific biosystem (from WikiPathways)
      Oxidative Damage, organism-specific biosystemThis pathway shows how tissue is damaged when oxygen levels are not balanced and become too high.
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC37479

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    WW domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine/tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    Grb2-EGFR complex ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    activated CDC42 kinase 1
    Names
    Cdc42 GTPase-inhibiting protein
    P21cdc42Hs kinase
    non-receptor protein tyrosine kinase ACK
    tyrosine kinase non-receptor protein 2
    NP_001103617.1
    NP_001276372.1
    NP_058068.2
    XP_006522395.1
    XP_006522396.1
    XP_006522397.1
    XP_006522398.1
    XP_006522399.1
    XP_006522400.1
    XP_006522401.1
    XP_006522402.1
    XP_006522403.1
    XP_006522405.1
    XP_006522406.1
    XP_006522407.1
    XP_006522408.1
    XP_011244248.1
    XP_017172554.1
    XP_017172555.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110147.1NP_001103617.1  activated CDC42 kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_001103617.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      BC052421
      Consensus CDS
      CCDS49828.1
      UniProtKB/Swiss-Prot
      O54967
      UniProtKB/TrEMBL
      A0A0R4J1L0
      Related
      ENSMUSP00000110778.1, OTTMUSP00000030891, ENSMUST00000115125.7, OTTMUST00000062602
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:126385
      STYKc; Protein kinase; unclassified specificity
      cd14328
      Location:959998
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:447514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    2. NM_001289443.1NP_001276372.1  activated CDC42 kinase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR, lacks part of the 5' coding region, lacks two in-frame exons in the central coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC161755, BB583500, BC052421
      UniProtKB/Swiss-Prot
      O54967
      Conserved Domains (2) summary
      cd14328
      Location:469508
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam11555
      Location:284348
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    3. NM_001347185.1NP_001334114.1  activated CDC42 kinase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161755, BC052421
      Consensus CDS
      CCDS84224.1
      UniProtKB/Swiss-Prot
      O54967
      UniProtKB/TrEMBL
      D3Z3U7
    4. NM_016788.3NP_058068.2  activated CDC42 kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_058068.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161755, BQ770866, BU702226, DQ666696
      Consensus CDS
      CCDS37313.1
      UniProtKB/Swiss-Prot
      O54967
      UniProtKB/TrEMBL
      G3X9X7
      Related
      ENSMUSP00000110777.1, OTTMUSP00000030887, ENSMUST00000115124.7, OTTMUST00000062598
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:126385
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:9761019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:447514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      32644099..32683493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245946.1XP_011244248.1  activated CDC42 kinase 1 isoform X12

      Conserved Domains (7) summary
      smart00221
      Location:1215
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:806849
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:836875
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:1217
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:277344
      GTPase_binding; GTPase binding
      pfam11555
      Location:619683
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:225274
      SH3_9; Variant SH3 domain
    2. XM_017317066.1XP_017172555.1  activated CDC42 kinase 1 isoform X10

      UniProtKB/TrEMBL
      D3Z3U6
      Related
      ENSMUSP00000110776.1, OTTMUSP00000030889, ENSMUST00000115123.7, OTTMUST00000062600
    3. XM_006522335.1XP_006522398.1  activated CDC42 kinase 1 isoform X4

      Conserved Domains (8) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:150409
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:10001043
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10301069
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:471538
      GTPase_binding; GTPase binding
      pfam11555
      Location:813877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    4. XM_006522339.1XP_006522402.1  activated CDC42 kinase 1 isoform X9

      Conserved Domains (7) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:150409
      STYKc; Protein kinase; unclassified specificity
      cd14328
      Location:9981037
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:471538
      GTPase_binding; GTPase binding
      pfam11555
      Location:813877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    5. XM_006522332.3XP_006522395.1  activated CDC42 kinase 1 isoform X1

      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:158417
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:10081051
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10381077
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    6. XM_006522334.3XP_006522397.1  activated CDC42 kinase 1 isoform X3

      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:158417
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:10051049
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10361075
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    7. XM_006522333.3XP_006522396.1  activated CDC42 kinase 1 isoform X2

      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:158417
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:10081051
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10381077
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    8. XM_017317065.1XP_017172554.1  activated CDC42 kinase 1 isoform X6

    9. XM_006522337.3XP_006522400.1  activated CDC42 kinase 1 isoform X7

      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:158417
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:9901034
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10211060
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    10. XM_006522340.3XP_006522403.1  activated CDC42 kinase 1 isoform X11

      Conserved Domains (7) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:158417
      STYKc; Protein kinase; unclassified specificity
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    11. XM_006522338.3XP_006522401.1  activated CDC42 kinase 1 isoform X8

      Conserved Domains (7) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:158417
      STYKc; Protein kinase; unclassified specificity
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    12. XM_006522336.3XP_006522399.1  activated CDC42 kinase 1 isoform X5

      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:158417
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:9931036
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10231062
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    13. XM_006522342.3XP_006522405.1  activated CDC42 kinase 1 isoform X13

      Conserved Domains (5) summary
      cd14274
      Location:568611
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:598637
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam09027
      Location:39106
      GTPase_binding; GTPase binding
      pfam11555
      Location:381445
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      cl17036
      Location:636
      SH3; Src Homology 3 domain superfamily
    14. XM_006522345.2XP_006522408.1  activated CDC42 kinase 1 isoform X15

      Related
      ENSMUSP00000110773.1, OTTMUSP00000030890, ENSMUST00000115120.7, OTTMUST00000062601
      Conserved Domains (3) summary
      cd14274
      Location:471514
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:501540
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam11555
      Location:284348
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    15. XM_006522344.1XP_006522407.1  activated CDC42 kinase 1 isoform X14

      See identical proteins and their annotated locations for XP_006522407.1

      Conserved Domains (3) summary
      cd14274
      Location:486529
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:516555
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam11555
      Location:299363
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    16. XM_006522343.1XP_006522406.1  activated CDC42 kinase 1 isoform X14

      See identical proteins and their annotated locations for XP_006522406.1

      Conserved Domains (3) summary
      cd14274
      Location:486529
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:516555
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam11555
      Location:299363
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
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