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    TASP1 taspase 1 [ Homo sapiens (human) ]

    Gene ID: 55617, updated on 5-Nov-2017
    Official Symbol
    TASP1provided by HGNC
    Official Full Name
    taspase 1provided by HGNC
    Primary source
    HGNC:HGNC:15859
    See related
    Ensembl:ENSG00000089123 MIM:608270; Vega:OTTHUMG00000031904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C20orf13; dJ585I14.2
    Summary
    This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    20p12.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (13104760..13638936, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (13370036..13619583, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1722 Neighboring gene long intergenic non-protein coding RNA 1723 Neighboring gene coiled-coil domain containing 84 pseudogene Neighboring gene serine palmitoyltransferase long chain base subunit 3 Neighboring gene uncharacterized LOC105372539 Neighboring gene ISM1 antisense RNA 1 Neighboring gene isthmin 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 2 Neighboring gene mitochondrial ribosomal protein S36 pseudogene 6 Neighboring gene ESF1 nucleolar pre-rRNA processing protein homolog Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 5

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ20212, MGC39159

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    threonine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    threonine aspartase 1
    NP_001310531.1
    NP_001310532.1
    NP_001310533.1
    NP_060184.2
    XP_011527594.1
    XP_011527596.1
    XP_016883416.1
    XP_016883417.1
    XP_016883418.1
    XP_016883419.1
    XP_016883420.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323602.1NP_001310531.1  threonine aspartase 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, AL601028, CA418131
      Conserved Domains (1) summary
      cd04514
      Location:42285
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    2. NM_001323603.1NP_001310532.1  threonine aspartase 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, CA418131
      Conserved Domains (1) summary
      cd04514
      Location:2314
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    3. NM_001323604.1NP_001310533.1  threonine aspartase 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, CA418131
      Conserved Domains (1) summary
      cd04514
      Location:2314
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    4. NM_017714.2NP_060184.2  threonine aspartase 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_060184.2

      Status: REVIEWED

      Source sequence(s)
      AL601028, BC025266, CA418131
      Consensus CDS
      CCDS13116.1
      UniProtKB/Swiss-Prot
      Q9H6P5
      Related
      ENSP00000338624.4, OTTHUMP00000030296, ENST00000337743.8, OTTHUMT00000078041
      Conserved Domains (1) summary
      cd04514
      Location:42416
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

    RNA

    1. NR_136628.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, CA418131
    2. NR_136629.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, AL601028, CA418131
    3. NR_136630.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, AL601028, CA418131
    4. NR_136631.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL121754, AL121782, AL601028, CA418131

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      13104760..13638936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027930.1XP_016883419.1  threonine aspartase 1 isoform X3

    2. XM_011529292.1XP_011527594.1  threonine aspartase 1 isoform X1

      See identical proteins and their annotated locations for XP_011527594.1

      Conserved Domains (1) summary
      cd04514
      Location:2314
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    3. XM_011529294.1XP_011527596.1  threonine aspartase 1 isoform X1

      See identical proteins and their annotated locations for XP_011527596.1

      Conserved Domains (1) summary
      cd04514
      Location:2314
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    4. XM_017027927.1XP_016883416.1  threonine aspartase 1 isoform X1

      Conserved Domains (1) summary
      cd04514
      Location:2314
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    5. XM_017027928.1XP_016883417.1  threonine aspartase 1 isoform X1

      Conserved Domains (1) summary
      cd04514
      Location:2314
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins
    6. XM_017027929.1XP_016883418.1  threonine aspartase 1 isoform X2

    7. XM_017027931.1XP_016883420.1  threonine aspartase 1 isoform X4

    RNA

    1. XR_001754319.1 RNA Sequence

    2. XR_430268.1 RNA Sequence

      Related
      ENST00000480436.5
    3. XR_001754321.1 RNA Sequence

    4. XR_001754320.1 RNA Sequence

    5. XR_001754323.1 RNA Sequence

    6. XR_001754325.1 RNA Sequence

    7. XR_001754324.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      13370132..13618116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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