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    Ldha lactate dehydrogenase A [ Mus musculus (house mouse) ]

    Gene ID: 16828, updated on 12-Mar-2017
    Official Symbol
    Ldhaprovided by MGI
    Official Full Name
    lactate dehydrogenase Aprovided by MGI
    Primary source
    MGI:MGI:96759
    See related
    Ensembl:ENSMUSG00000063229 Vega:OTTMUSG00000016500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ldh1; Ldhm; l7R2
    Summary
    The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]
    Orthologs
    Location:
    7 B3; 7 30.6 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (46845804..46855627)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (54101174..54110997)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene general transcription factor II H, polypeptide 1 Neighboring gene Rap1A-retro1 Neighboring gene predicted gene 5331 Neighboring gene predicted gene, 39011 Neighboring gene lactate dehydrogenase C Neighboring gene tumor susceptibility gene 101

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    L-lactate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    L-lactate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    L-lactate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    lactate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to extracellular stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose catabolic process to lactate via pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lactate biosynthetic process from pyruvate IC
    Inferred by Curator
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    sperm fibrous sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    L-lactate dehydrogenase A chain
    Names
    LDH muscle subunit
    LDH-M
    M-LDH
    lactate dehydrogenase 1, A chain
    lactate dehydrogenase A4
    NP_001129541.2
    NP_034829.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136069.2NP_001129541.2  L-lactate dehydrogenase A chain isoform 2

      See identical proteins and their annotated locations for NP_001129541.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon that results in a distinct 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus compared to isoform 1.
      Source sequence(s)
      AK150156, BC094428, BY195537
      Consensus CDS
      CCDS52255.1
      UniProtKB/TrEMBL
      A0A1B0GSX0, Q564E2
      Related
      ENSMUSP00000148107, ENSMUST00000209984
      Conserved Domains (2) summary
      cd05293
      Location:48358
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:54353
      L-LDH-NAD; L-lactate dehydrogenase
    2. NM_010699.2NP_034829.1  L-lactate dehydrogenase A chain isoform 1

      See identical proteins and their annotated locations for NP_034829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      AC090123, BC094428, BY227595
      Consensus CDS
      CCDS21289.1
      UniProtKB/Swiss-Prot
      P06151
      UniProtKB/TrEMBL
      Q564E2
      Related
      ENSMUSP00000036386, OTTMUSP00000017774, ENSMUST00000048209, OTTMUST00000039849
      Conserved Domains (2) summary
      cd05293
      Location:19329
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:25324
      L-LDH-NAD; L-lactate dehydrogenase

    RNA

    1. NR_102727.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK171373, AU079257, BC094428
      Related
      ENSMUST00000209548, OTTMUST00000147435

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      46845804..46855627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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