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    ALOX5 arachidonate 5-lipoxygenase [ Homo sapiens (human) ]

    Gene ID: 240, updated on 8-Apr-2018
    Official Symbol
    ALOX5provided by HGNC
    Official Full Name
    arachidonate 5-lipoxygenaseprovided by HGNC
    Primary source
    HGNC:HGNC:435
    See related
    Ensembl:ENSG00000012779 MIM:152390; Vega:OTTHUMG00000018081
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5-LO; 5LPG; LOG5; 5-LOX
    Summary
    This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Broad expression in bone marrow (RPKM 35.1), lung (RPKM 26.8) and 15 other tissues See more
    Orthologs
    Location:
    10q11.21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (45374166..45446121)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (45869624..45941569)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily D member 1 pseudogene Neighboring gene olfactory receptor family 13 subfamily A member 1 Neighboring gene uncharacterized LOC102724323 Neighboring gene uncharacterized LOC105378286 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene VISTA enhancer hs2065

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Asthma, susceptibility to
    MedGen: C1869116 OMIM: 600807 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of arachidonate 5-lipoxygenase (ALOX5) in human B cells PubMed
    env HIV-1 gp120 increases the intracellular concentrations of prostaglandin E2 and leukotriene B4 by upregulating the activity and expression of the arachidonate-metabolizing enzymes prostaglandin H synthase and 5-lipoxygenase, respectively PubMed

    Go to the HIV-1, Human Interaction Database

    • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
      Arachidonic acid metabolism, organism-specific biosystem
      Arachidonic acid metabolism
    • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
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    • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
      Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
    • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
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    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
      Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
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    • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
      Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • Ovarian steroidogenesis, conserved biosystem (from KEGG)
      Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • Selenium Micronutrient Network, organism-specific biosystem (from WikiPathways)
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      Selenium Micronutrient Network
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Synthesis of 5-eicosatetraenoic acids, organism-specific biosystem (from REACTOME)
      Synthesis of 5-eicosatetraenoic acids, organism-specific biosystem5-hydroperoxy-eicosatetraenoic acid (5-HpETE), 5-hydroxyeicosatetraenoic acid (5S-HETE) and 5-oxo-eicosatetraenoic acid (5-oxoETE) are formed after the initial step of arachidonic acid oxidation by ...
    • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
      Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
    • Synthesis of Lipoxins (LX), organism-specific biosystem (from REACTOME)
      Synthesis of Lipoxins (LX), organism-specific biosystemLipoxins A4 (LXA4) and B4 (LXB4), structurally characterized from human neutrophils incubated with 15-hydroperoxy-eicosatetraenoic acid (15-HpETE), each contain three hydroxyl moieties and a conjugat...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
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    • aspirin-triggered lipoxin biosynthesis, conserved biosystem (from BIOCYC)
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    • leukotriene biosynthesis, organism-specific biosystem (from BIOCYC)
      leukotriene biosynthesis, organism-specific biosystemLeukotrienes are made by cells of the immune system, mainly the mediators of inflammation like polymorphonuclear leukocytes, macrophages and mast cells. Cellular activation during inflammation leads ...
    • leukotriene biosynthesis, conserved biosystem (from BIOCYC)
      leukotriene biosynthesis, conserved biosystemLeukotrienes are proinflammatory metabolites of arachidonic acid that activate and amplify innate and adaptive immune responses. They also have roles in pathologic immune responses, mediating contrac...
    • lipoxin biosynthesis, organism-specific biosystem (from BIOCYC)
      lipoxin biosynthesis, organism-specific biosystemGeneral Background Lipoxins belong to the eicosanoid family, have a distinct conjugated tetraene structure and are generated from : ARACHIDONIC_ACID during inflammation. They consist of two distinct...
    • lipoxin biosynthesis, conserved biosystem (from BIOCYC)
      lipoxin biosynthesis, conserved biosystemGeneral Background Lipoxins belong to the eicosanoid family, have a distinct conjugated tetraene structure and are generated from |FRAME: ARACHIDONIC_ACID| during inflammation. They consist of two d...
    • resolvin D biosynthesis, organism-specific biosystem (from BIOCYC)
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    • resolvin D biosynthesis, conserved biosystem (from BIOCYC)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC163204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    arachidonate 5-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    iron ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    interleukin-18-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    leukotriene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukotriene metabolic process TAS
    Traceable Author Statement
    more info
     
    leukotriene production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    lipoxin biosynthetic process TAS
    Traceable Author Statement
    more info
     
    lipoxygenase pathway TAS
    Traceable Author Statement
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space HDA PubMed 
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope TAS
    Traceable Author Statement
    more info
     
    nuclear envelope lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    arachidonate 5-lipoxygenase
    Names
    LOX-5
    arachidonic 5-lipoxygenase alpha-10 isoform
    arachidonic 5-lipoxygenase delta-10-13 isoform
    arachidonic 5-lipoxygenase delta-13 isoform
    arachidonic 5-lipoxygenase delta-p10 isoform
    arachidonic acid 5-lipoxygenase
    leukotriene A4 synthase
    NP_000689.1
    NP_001243082.1
    NP_001243083.1
    NP_001307790.1
    NP_001307791.1
    XP_016871501.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011437.1 RefSeqGene

      Range
      4986..76939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000698.4NP_000689.1  arachidonate 5-lipoxygenase isoform 1

      See identical proteins and their annotated locations for NP_000689.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AW403395, BC132677, HY102907
      Consensus CDS
      CCDS7212.1
      UniProtKB/Swiss-Prot
      P09917
      Related
      ENSP00000363512.2, OTTHUMP00000019502, ENST00000374391.6, OTTHUMT00000047780
      Conserved Domains (2) summary
      cd01753
      Location:2115
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      cl27717
      Location:227665
      Lipoxygenase; Lipoxygenase
    2. NM_001256153.2NP_001243082.1  arachidonate 5-lipoxygenase isoform 2

      See identical proteins and their annotated locations for NP_001243082.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK225603, AK315223, AW403395, BC132677, HY102907
      UniProtKB/Swiss-Prot
      P09917
      Conserved Domains (2) summary
      cd01753
      Location:2115
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:227633
      Lipoxygenase; Lipoxygenase
    3. NM_001256154.2NP_001243083.1  arachidonate 5-lipoxygenase isoform 3

      See identical proteins and their annotated locations for NP_001243083.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AW403395, BC143985, HY102907
      Consensus CDS
      CCDS58078.1
      UniProtKB/Swiss-Prot
      P09917
      Related
      ENSP00000437634.1, ENST00000542434.5
      Conserved Domains (2) summary
      cd01753
      Location:2115
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:227608
      Lipoxygenase; Lipoxygenase
    4. NM_001320861.1NP_001307790.1  arachidonate 5-lipoxygenase isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AL731567, AW403395, BC132677, HY102907
      UniProtKB/Swiss-Prot
      P09917
      Conserved Domains (2) summary
      cd01753
      Location:2115
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:227636
      Lipoxygenase; Lipoxygenase
    5. NM_001320862.1NP_001307791.1  arachidonate 5-lipoxygenase isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at a downstream start site compared to variant 1. The encoded isoform (5) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AW403395, BC143986, HY102907
      Conserved Domains (1) summary
      pfam00305
      Location:82520
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      45374166..45446121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016012.1XP_016871501.1  arachidonate 5-lipoxygenase isoform X1

      Conserved Domains (1) summary
      pfam00305
      Location:82520
      Lipoxygenase; Lipoxygenase

    RNA

    1. XR_001747075.1 RNA Sequence

    Reference GRCh38.p12 ALT_REF_LOCI_1

    Genomic

    1. NW_003315935.1 Reference GRCh38.p12 ALT_REF_LOCI_1

      Range
      214997..286950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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