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    Mmp13 matrix metallopeptidase 13 [ Mus musculus (house mouse) ]

    Gene ID: 17386, updated on 24-Apr-2018
    Official Symbol
    Mmp13provided by MGI
    Official Full Name
    matrix metallopeptidase 13provided by MGI
    Primary source
    MGI:MGI:1340026
    See related
    Ensembl:ENSMUSG00000050578 Vega:OTTMUSG00000062269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clg; Mmp1; MMP-13
    Summary
    This gene encodes a member of the matrix metalloproteinase family that plays a role in wound healing, skeletal development and bone remodeling. The encoded protein is activated by the removal of an N-terminal activation peptide to generate a zinc-dependent endopeptidase enzyme that can cleave various native collagens, including types I - IV, X and XIV. Mice lacking the encoded protein display profound defects in growth plate cartilage as well as a delay in the endochondral bone development. Lack of the encoded protein also impairs the wound healing process due to reduced keratinocyte migration and vascular density at the wound site. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Jun 2015]
    Expression
    Biased expression in CNS E18 (RPKM 1.3), limb E14.5 (RPKM 0.9) and 13 other tissues See more
    Orthologs
    See Mmp13 in Genome Data Viewer
    Location:
    9; 9 A1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (7272514..7283333)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (7272514..7283333)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) Neighboring gene predicted gene, 31639 Neighboring gene matrix metallopeptidase 12 Neighboring gene matrix metallopeptidase 1b (interstitial collagenase)

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    endochondral ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    growth plate cartilage development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    peptide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pancreatic trypsinogen secretion ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    intercellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    collagenase 3
    Names
    collagenase-1
    interstitial collagenase
    matrix metalloproteinase 13
    NP_032633.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008607.2NP_032633.1  collagenase 3 preproprotein

      See identical proteins and their annotated locations for NP_032633.1

      Status: REVIEWED

      Source sequence(s)
      AC174457, AK150728, BC125320
      Consensus CDS
      CCDS22803.1
      UniProtKB/Swiss-Prot
      P33435
      UniProtKB/TrEMBL
      Q3U9V5
      Related
      ENSMUSP00000015394.8, OTTMUSP00000078751, ENSMUST00000015394.9, OTTMUST00000151898
      Conserved Domains (4) summary
      cd00094
      Location:282472
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:113268
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:113268
      Peptidase_M10; Matrixin
      pfam01471
      Location:3392
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      7272514..7283333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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