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    PLAT plasminogen activator, tissue type [ Homo sapiens (human) ]

    Gene ID: 5327, updated on 5-Nov-2017
    Official Symbol
    PLATprovided by HGNC
    Official Full Name
    plasminogen activator, tissue typeprovided by HGNC
    Primary source
    HGNC:HGNC:9051
    See related
    Ensembl:ENSG00000104368 MIM:173370; Vega:OTTHUMG00000164072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TPA; T-PA
    Summary
    This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
    Orthologs
    Location:
    8p11.21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (42174718..42207724, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (42032236..42065242, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986939 Neighboring gene adaptor related protein complex 3 mu 2 subunit Neighboring gene uncharacterized LOC101929897 Neighboring gene inhibitor of nuclear factor kappa B kinase subunit beta Neighboring gene uncharacterized LOC105379395

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Thrombophilia, familial, due to decreased release of tissue plasminogen activator
    MedGen: C2676721 OMIM: 612348 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp686I03148

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    fibrinolysis TAS
    Traceable Author Statement
    more info
     
    negative regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasminogen activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis TAS
    Traceable Author Statement
    more info
    PubMed 
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    tissue-type plasminogen activator
    Names
    alteplase
    plasminogen/activator kringle
    reteplase
    t-plasminogen activator
    NP_000921.1
    NP_001306118.1
    NP_127509.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023264.1 RefSeqGene

      Range
      5001..37959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_570

    mRNA and Protein(s)

    1. NM_000930.4NP_000921.1  tissue-type plasminogen activator isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_000921.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC083973, BC013968, DA031108, DC424502
      Consensus CDS
      CCDS6126.1
      UniProtKB/Swiss-Prot
      P00750
      Related
      ENSP00000220809.4, OTTHUMP00000225784, ENST00000220809.8, OTTHUMT00000377100
      Conserved Domains (4) summary
      smart00058
      Location:4183
      FN1; Fibronectin type 1 domain
      cd00108
      Location:125209
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00190
      Location:313559
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:215296
      Kringle; Kringle domain
    2. NM_001319189.1NP_001306118.1  tissue-type plasminogen activator isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1. This isoform (4) may undergo proteolytic processing similar to isoform 1.
      Source sequence(s)
      AC083973, AK297738, BC002795, DA031108, DC424502
      Consensus CDS
      CCDS83291.1
      UniProtKB/Swiss-Prot
      P00750
      UniProtKB/TrEMBL
      B4DN26
      Related
      ENSP00000429401.1, OTTHUMP00000225788, ENST00000524009.5, OTTHUMT00000377104
      Conserved Domains (4) summary
      smart00020
      Location:221467
      Tryp_SPc; Trypsin-like serine protease
      smart00058
      Location:4183
      FN1; Fibronectin type 1 domain
      cd00190
      Location:224470
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:126207
      Kringle; Kringle domain
    3. NM_033011.3NP_127509.1  tissue-type plasminogen activator isoform 3 precursor

      See identical proteins and their annotated locations for NP_127509.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 1.
      Source sequence(s)
      AC083973, BC002795, DA031108, DC424502
      Consensus CDS
      CCDS6127.1
      UniProtKB/Swiss-Prot
      P00750
      Related
      ENSP00000270188.6, OTTHUMP00000225785, ENST00000352041.7, OTTHUMT00000377101
      Conserved Domains (4) summary
      smart00020
      Location:264510
      Tryp_SPc; Trypsin-like serine protease
      cd00108
      Location:79163
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00190
      Location:267513
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:169250
      Kringle; Kringle domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      42174718..42207724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      42080535..42113859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_000931.2: Suppressed sequence

      Description
      NM_000931.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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