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    TRAIP TRAF interacting protein [ Homo sapiens (human) ]

    Gene ID: 10293, updated on 19-May-2018
    Official Symbol
    TRAIPprovided by HGNC
    Official Full Name
    TRAF interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:30764
    See related
    Ensembl:ENSG00000183763 MIM:605958; Vega:OTTHUMG00000158269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRIP; SCKL9; RNF206
    Summary
    This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 4.0), bone marrow (RPKM 2.3) and 23 other tissues See more
    Orthologs
    See TRAIP in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (49828595..49856584, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49866028..49893992, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene inka box actin regulator 1 Neighboring gene microRNA 5193 Neighboring gene ubiquitin like modifier activating enzyme 7 Neighboring gene CaM kinase like vesicle associated Neighboring gene RNA, 7SL, cytoplasmic 217, pseudogene Neighboring gene actin, beta pseudogene 13

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase TRAIP
    Names
    RING-type E3 ubiquitin transferase TRAIP
    ring finger protein 206
    NP_005870.2
    XP_011531566.1
    XP_016861015.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046695.1 RefSeqGene

      Range
      5001..32965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005879.2NP_005870.2  E3 ubiquitin-protein ligase TRAIP

      See identical proteins and their annotated locations for NP_005870.2

      Status: REVIEWED

      Source sequence(s)
      BC019283, BQ446539, BX473682
      Consensus CDS
      CCDS2806.1
      UniProtKB/Swiss-Prot
      Q9BWF2
      Related
      ENSP00000328203.2, OTTHUMP00000212706, ENST00000331456.6, OTTHUMT00000350518
      Conserved Domains (2) summary
      cd16480
      Location:650
      RING-H2_TRAIP; RING finger, H2 subclass, found in TRAF-interacting protein (TRAIP) and similar proteins
      cl25732
      Location:68279
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      49828595..49856584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005526.1XP_016861015.1  E3 ubiquitin-protein ligase TRAIP isoform X2

    2. XM_011533264.1XP_011531566.1  E3 ubiquitin-protein ligase TRAIP isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:17202
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_001739979.1 RNA Sequence

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