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    Senp8 SUMO/sentrin specific peptidase 8 [ Mus musculus (house mouse) ]

    Gene ID: 71599, updated on 13-Aug-2017
    Official Symbol
    Senp8provided by MGI
    Official Full Name
    SUMO/sentrin specific peptidase 8provided by MGI
    Primary source
    MGI:MGI:1918849
    See related
    Ensembl:ENSMUSG00000051705 Vega:OTTMUSG00000063327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Den1; Nedp1; Prsc2; AU020827; 9130010J17Rik
    Orthologs
    Location:
    9; 9 B
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (59734259..59750649, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (59582066..59598456, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene pyruvate kinase, muscle Neighboring gene GRAM domain containing 2 Neighboring gene predicted gene, 39347 Neighboring gene myosin IXa Neighboring gene predicted gene 7613 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 20275

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NEDD8-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    SUMO-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    sentrin-specific protease 8
    Names
    NEDD8-specific protease 1
    SUMO/sentrin specific protease 8
    SUMO/sentrin specific protease family member 8
    deneddylase-1
    protease, cysteine, 2 (NEDD8 specific)
    sentrin/SUMO-specific protease SENP8
    NP_001165539.1
    NP_001165540.1
    NP_001165541.1
    NP_001165542.1
    NP_082114.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172068.1NP_001165539.1  sentrin-specific protease 8 isoform a

      See identical proteins and their annotated locations for NP_001165539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
      Source sequence(s)
      AK018606, AK029856, AK049120, BB522944, DV645349
      Consensus CDS
      CCDS23254.1
      UniProtKB/Swiss-Prot
      Q9D2Z4
      UniProtKB/TrEMBL
      A0A0R4J234
      Related
      ENSMUSP00000150601.1, OTTMUSP00000079778, ENSMUST00000217093.1, OTTMUST00000154273
      Conserved Domains (1) summary
      cl23802
      Location:26188
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. NM_001172069.1NP_001165540.1  sentrin-specific protease 8 isoform a

      See identical proteins and their annotated locations for NP_001165540.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
      Source sequence(s)
      AK029856, BB522944, CO431667, DV645349
      Consensus CDS
      CCDS23254.1
      UniProtKB/Swiss-Prot
      Q9D2Z4
      UniProtKB/TrEMBL
      A0A0R4J234
      Related
      ENSMUSP00000150192.1, OTTMUSP00000079779, ENSMUST00000213257.1, OTTMUST00000154274
      Conserved Domains (1) summary
      cl23802
      Location:26188
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    3. NM_001172070.1NP_001165541.1  sentrin-specific protease 8 isoform a

      See identical proteins and their annotated locations for NP_001165541.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
      Source sequence(s)
      AK029856, AK136214, BB522944, DV645349
      Consensus CDS
      CCDS23254.1
      UniProtKB/Swiss-Prot
      Q9D2Z4
      UniProtKB/TrEMBL
      A0A0R4J234, Q3UWN3
      Related
      ENSMUSP00000129441.2, OTTMUSP00000079776, ENSMUST00000163586.8, OTTMUST00000154271
      Conserved Domains (1) summary
      cl23802
      Location:26188
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    4. NM_001172071.1NP_001165542.1  sentrin-specific protease 8 isoform b

      See identical proteins and their annotated locations for NP_001165542.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and includes an uses an start codon, compared to variant 1. The resulting isoform (b) has a longer N-terminus, compared to isoform a.
      Source sequence(s)
      AK018606, AK029856, BB522944, DV645349
      Consensus CDS
      CCDS52819.1
      UniProtKB/Swiss-Prot
      Q9D2Z4
      UniProtKB/TrEMBL
      A0A1L1SRH8
      Related
      ENSMUSP00000149463.1, OTTMUSP00000079777, ENSMUST00000216329.1, OTTMUST00000154272
      Conserved Domains (1) summary
      cl23802
      Location:39201
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    5. NM_027838.3NP_082114.1  sentrin-specific protease 8 isoform a

      See identical proteins and their annotated locations for NP_082114.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b).
      Source sequence(s)
      AK029856, BB522944, DV645349
      Consensus CDS
      CCDS23254.1
      UniProtKB/Swiss-Prot
      Q9D2Z4
      UniProtKB/TrEMBL
      A0A0R4J234
      Related
      ENSMUSP00000054509.4, OTTMUSP00000079775, ENSMUST00000051039.4, OTTMUST00000154270
      Conserved Domains (1) summary
      cl23802
      Location:26188
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      59734259..59750649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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