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    TRPM5 transient receptor potential cation channel subfamily M member 5 [ Homo sapiens (human) ]

    Gene ID: 29850, updated on 12-Mar-2017
    Official Symbol
    TRPM5provided by HGNC
    Official Full Name
    transient receptor potential cation channel subfamily M member 5provided by HGNC
    Primary source
    HGNC:HGNC:14323
    See related
    Ensembl:ENSG00000070985 MIM:604600; Vega:OTTHUMG00000009896
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTR1; LTRPC5
    Summary
    This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]
    Orthologs
    Location:
    11p15.5
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (2403962..2423424, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2425745..2444275, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CD81 antisense RNA 1 Neighboring gene CD81 molecule Neighboring gene tumor suppressing subtransferable candidate 4 Neighboring gene potassium voltage-gated channel subfamily Q member 1 Neighboring gene KCNQ1 opposite strand/antisense transcript 1 (non-protein coding) Neighboring gene cytochrome c oxidase subunit 6C pseudogene 18

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
    NHGRI GWA Catalog
    • Ion channel transport, organism-specific biosystem (from REACTOME)
      Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
    • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
      Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
    • TRP channels, organism-specific biosystem (from REACTOME)
      TRP channels, organism-specific biosystemTransient receptor potential (TRP) channel proteins were first discovered in Drosophila melanogaster and have many homologues in other species including humans. TRPs form cationic channels that can ...
    • Taste transduction, organism-specific biosystem (from KEGG)
      Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • Taste transduction, conserved biosystem (from KEGG)
      Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    sodium channel activity TAS
    Traceable Author Statement
    more info
     
    voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    calcium ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
     
    sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    transient receptor potential cation channel subfamily M member 5
    Names
    LTrpC-5
    MLSN1 and TRP-related
    MLSN1- and TRP-related gene 1 protein
    TRPM5
    long transient receptor potential channel 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014555.3NP_055370.1  transient receptor potential cation channel subfamily M member 5

      See identical proteins and their annotated locations for NP_055370.1

      Status: REVIEWED

      Source sequence(s)
      AF177473, AJ270996
      Consensus CDS
      CCDS31340.1
      UniProtKB/Swiss-Prot
      Q9NZQ8
      Related
      ENSP00000155858, OTTHUMP00000011536, ENST00000155858, OTTHUMT00000027378
      Conserved Domains (1) summary
      COG0515
      Location:253342
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      2403962..2423424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017628.1XP_016873117.1  transient receptor potential cation channel subfamily M member 5 isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      2424619..2443104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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