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    ZNF382 zinc finger protein 382 [ Homo sapiens (human) ]

    Gene ID: 84911, updated on 8-May-2017
    Official Symbol
    ZNF382provided by HGNC
    Official Full Name
    zinc finger protein 382provided by HGNC
    Primary source
    HGNC:HGNC:17409
    See related
    Ensembl:ENSG00000161298 MIM:609516; Vega:OTTHUMG00000048153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KS1
    Summary
    This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
    Orthologs
    Location:
    19q13.12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (36605305..36628597)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37096207..37119499)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 260 Neighboring gene zinc finger protein 529 Neighboring gene ZNF529 antisense RNA 1 Neighboring gene zinc finger protein 461 Neighboring gene zinc finger protein 567 Neighboring gene long intergenic non-protein coding RNA 1534

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ14686

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    zinc finger protein 382
    Names
    KRAB/zinc finger suppressor protein 1
    multiple zinc finger and krueppel-associated box protein KS1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256838.1NP_001243767.1  zinc finger protein 382 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and initiates translation at an upstream start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF513816, BC132675, CD690493
      Consensus CDS
      CCDS58659.1
      UniProtKB/Swiss-Prot
      Q96SR6
      Related
      ENSP00000407593.1, OTTHUMP00000208122, ENST00000439428.5, OTTHUMT00000340398
      Conserved Domains (6) summary
      smart00349
      Location:666
      KRAB; krueppel associated box
      COG5048
      Location:353532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:381401
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:493513
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:645
      KRAB; KRAB box
      pfam13465
      Location:505530
      zf-H2C2_2; Zinc-finger double domain
    2. NM_032825.4NP_116214.2  zinc finger protein 382 isoform 1

      See identical proteins and their annotated locations for NP_116214.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF513816, CD690493
      Consensus CDS
      CCDS33004.1
      UniProtKB/Swiss-Prot
      Q96SR6
      Related
      ENSP00000292928.2, OTTHUMP00000045834, ENST00000292928.6, OTTHUMT00000109562
      Conserved Domains (6) summary
      smart00349
      Location:767
      KRAB; krueppel associated box
      COG5048
      Location:354533
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382402
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:494514
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:746
      KRAB; KRAB box
      pfam13465
      Location:506531
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      36605305..36628597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      37096795..37120088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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