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    Tnfrsf25 tumor necrosis factor receptor superfamily, member 25 [ Mus musculus (house mouse) ]

    Gene ID: 85030, updated on 25-May-2017
    Official Symbol
    Tnfrsf25provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 25provided by MGI
    Primary source
    MGI:MGI:1934667
    See related
    Ensembl:ENSMUSG00000024793 Vega:OTTMUSG00000010224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DR3; TR3; Wsl; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; Tnfrsf12
    Orthologs
    Location:
    4; 4 E2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (152115528..152120119)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (151490452..151494220)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene nucleolar protein 9 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 5 Neighboring gene espin Neighboring gene espin-like pseudogene Neighboring gene predicted gene, 20377

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    tumor necrosis factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    tumor necrosis factor receptor superfamily member 25
    Names
    tumor necrosis factor receptor superfamily, member 12

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291010.1NP_001277939.1  tumor necrosis factor receptor superfamily member 25 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001277939.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL772240
      Consensus CDS
      CCDS71527.1
      UniProtKB/TrEMBL
      B1AWN9
      Related
      ENSMUSP00000025706.3, OTTMUSP00000010872, ENSMUST00000025706.9, OTTMUST00000023754
      Conserved Domains (2) summary
      cd13420
      Location:37150
      TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
      cl14633
      Location:328404
      DD; Death Domain Superfamily of protein-protein interaction domains
    2. NM_033042.4NP_149031.2  tumor necrosis factor receptor superfamily member 25 isoform 2 precursor

      See identical proteins and their annotated locations for NP_149031.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon and lacks two consecutive exons in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL772240
      Consensus CDS
      CCDS38983.1
      UniProtKB/TrEMBL
      Q8VD70
      Related
      ENSMUSP00000047823.7, OTTMUSP00000010995, ENSMUST00000035275.7, OTTMUST00000023979
      Conserved Domains (2) summary
      cd13420
      Location:50163
      TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
      cl14633
      Location:304380
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      152115528..152120119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539318.2XP_006539381.1  tumor necrosis factor receptor superfamily member 25 isoform X1

      Conserved Domains (2) summary
      cd13420
      Location:50163
      TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
      cl14633
      Location:341417
      DD; Death Domain Superfamily of protein-protein interaction domains
    2. XM_011250362.1XP_011248664.1  tumor necrosis factor receptor superfamily member 25 isoform X3

      Conserved Domains (1) summary
      cl14633
      Location:177253
      DD; Death Domain Superfamily of protein-protein interaction domains
    3. XM_006539319.2XP_006539382.1  tumor necrosis factor receptor superfamily member 25 isoform X2

      Conserved Domains (2) summary
      cd13420
      Location:66157
      TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
      cl14633
      Location:335411
      DD; Death Domain Superfamily of protein-protein interaction domains
    4. XM_011250363.1XP_011248665.1  tumor necrosis factor receptor superfamily member 25 isoform X4

      Conserved Domains (1) summary
      cl14633
      Location:157233
      DD; Death Domain Superfamily of protein-protein interaction domains

    RNA

    1. XR_881438.1 RNA Sequence

    2. XR_881439.1 RNA Sequence

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