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    SLC7A8 solute carrier family 7 member 8 [ Homo sapiens (human) ]

    Gene ID: 23428, updated on 22-Apr-2017
    Official Symbol
    SLC7A8provided by HGNC
    Official Full Name
    solute carrier family 7 member 8provided by HGNC
    Primary source
    HGNC:HGNC:11066
    See related
    Ensembl:ENSG00000092068 MIM:604235; Vega:OTTHUMG00000028720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAT2; LPI-PC1
    Orthologs
    Location:
    14q11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (23125295..23183660, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23594504..23652869, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984665 Neighboring gene uncharacterized LOC107984666 Neighboring gene CCAAT/enhancer binding protein epsilon Neighboring gene RNA, U6 small nuclear 1138, pseudogene Neighboring gene uncharacterized LOC105370406 Neighboring gene ring finger protein 212B Neighboring gene ribosomal protein L39 pseudogene 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Amino acid transport across the plasma membrane, organism-specific biosystem (from REACTOME)
      Amino acid transport across the plasma membrane, organism-specific biosystemAmino acid transport across plasma membranes is critical to the uptake of these molecules from the gut, to their reabsortion in the kidney proximal tubulues, and to their distribution to cells in whi...
    • Basigin interactions, organism-specific biosystem (from REACTOME)
      Basigin interactions, organism-specific biosystemBasigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interaction...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
      Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemTeleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    amino acid transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    PubMed 
    amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neutral amino acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    organic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide antigen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    toxin transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    amino acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    amino acid transport TAS
    Traceable Author Statement
    more info
     
    cellular amino acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    metal ion homeostasis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    organic cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    response to toxic substance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    toxin transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    large neutral amino acids transporter small subunit 2
    Names
    L-type amino acid transporter 2
    integral membrane protein E16H
    solute carrier family 7 (amino acid transporter light chain, L system), member 8
    solute carrier family 7 (amino acid transporter, L-type), member 8
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267036.1NP_001253965.1  large neutral amino acids transporter small subunit 2 isoform c

      See identical proteins and their annotated locations for NP_001253965.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AB037669, AF135830, AK296702, AL117258, BX248288
      Consensus CDS
      CCDS58305.1
      UniProtKB/Swiss-Prot
      Q9UHI5
      Related
      ENSP00000434345.2, OTTHUMP00000228619, ENST00000529705.6, OTTHUMT00000382163
      Conserved Domains (1) summary
      TIGR00911
      Location:65392
      2A0308; L-type amino acid transporter
    2. NM_001267037.1NP_001253966.1  large neutral amino acids transporter small subunit 2 isoform d

      See identical proteins and their annotated locations for NP_001253966.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon and lacks an exon in the coding region, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AB037669, AF135830, AK300384, BX248288, DC348596
      Consensus CDS
      CCDS58304.1
      UniProtKB/Swiss-Prot
      Q9UHI5
      Related
      ENSP00000416398.2, ENST00000422941.6
      Conserved Domains (1) summary
      TIGR00911
      Location:39273
      2A0308; L-type amino acid transporter
    3. NM_012244.3NP_036376.2  large neutral amino acids transporter small subunit 2 isoform a

      See identical proteins and their annotated locations for NP_036376.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AB037669, AF135830, AK223610, AK313465, AL365343, BX248288
      Consensus CDS
      CCDS9590.1
      UniProtKB/Swiss-Prot
      Q9UHI5
      UniProtKB/TrEMBL
      Q53EM9
      Related
      ENSP00000320378.7, OTTHUMP00000164556, ENST00000316902.11, OTTHUMT00000071718
      Conserved Domains (1) summary
      TIGR00911
      Location:1497
      2A0308; L-type amino acid transporter
    4. NM_182728.2NP_877392.1  large neutral amino acids transporter small subunit 2 isoform b

      See identical proteins and their annotated locations for NP_877392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AB037669, AF135830, BX248288, DC348596
      Consensus CDS
      CCDS41924.1
      UniProtKB/Swiss-Prot
      Q9UHI5
      Related
      ENSP00000391577.1, OTTHUMP00000164557, ENST00000453702.5, OTTHUMT00000071719
      Conserved Domains (1) summary
      TIGR00911
      Location:1294
      2A0308; L-type amino acid transporter

    RNA

    1. NR_049767.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate 5'-most exon and lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB037669, AF135830, AL117258, BC036825, BX248288
      Related
      ENST00000339733.9, OTTHUMT00000382160

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      23125295..23183660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      23593107..23651472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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