Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    RRN3 RRN3 homolog, RNA polymerase I transcription factor [ Homo sapiens (human) ]

    Gene ID: 54700, updated on 19-May-2018
    Official Symbol
    RRN3provided by HGNC
    Official Full Name
    RRN3 homolog, RNA polymerase I transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:30346
    See related
    Ensembl:ENSG00000085721 MIM:605121; Vega:OTTHUMG00000129847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIFIA; A-270G1.2
    Expression
    Ubiquitous expression in bone marrow (RPKM 15.3), thyroid (RPKM 14.8) and 25 other tissues See more
    Orthologs
    See RRN3 in Genome Data Viewer
    Location:
    16p13.11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (15060022..15094335, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (15153879..15188168, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene pyridoxal dependent decarboxylase domain containing 1 Neighboring gene microRNA 1972-1 Neighboring gene N-terminal asparagine amidase Neighboring gene uncharacterized LOC100505915 Neighboring gene PKD1P6-NPIPP1 readthrough Neighboring gene nuclear pore complex interacting protein pseudogene 1 Neighboring gene polycystin 1, transient receptor potential channel interacting pseudogene 6 Neighboring gene microRNA 6511b-2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC104238, DKFZp566E104

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase I CORE element sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase I core binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription factor activity, core RNA polymerase I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    RNA polymerase I transcriptional preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm organization IEA
    Inferred from Electronic Annotation
    more info
     
    homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus organization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of DNA-templated transcription, initiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
     
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transcription initiation from RNA polymerase I promoter TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    RNA polymerase I-specific transcription initiation factor RRN3
    Names
    RRN3 RNA polymerase I transcription factor homolog
    TIF-IA
    transcription initiation factor IA
    transcription initiation factor TIF-IA

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301064.1NP_001287993.1  RNA polymerase I-specific transcription initiation factor RRN3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AK316520, BC036182, CK906270, DA764092, DC376629
      Consensus CDS
      CCDS73833.1
      UniProtKB/TrEMBL
      B7ZB55, F5H148
      Related
      ENSP00000402027.2, OTTHUMP00000250208, ENST00000429751.6, OTTHUMT00000422445
      Conserved Domains (1) summary
      pfam05327
      Location:85555
      RRN3; RNA polymerase I specific transcription initiation factor RRN3
    2. NM_018427.4NP_060897.3  RNA polymerase I-specific transcription initiation factor RRN3 isoform 1

      See identical proteins and their annotated locations for NP_060897.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC036182, BC132688, CK906270, DC376629
      Consensus CDS
      CCDS10559.1
      UniProtKB/Swiss-Prot
      Q9NYV6
      Related
      ENSP00000198767.6, OTTHUMP00000160284, ENST00000198767.10, OTTHUMT00000252087
      Conserved Domains (1) summary
      pfam05327
      Location:64585
      RRN3; RNA polymerase I specific transcription initiation factor RRN3

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      Range
      15060022..15094335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005255377.5XP_005255434.1  RNA polymerase I-specific transcription initiation factor RRN3 isoform X3

      See identical proteins and their annotated locations for XP_005255434.1

      Conserved Domains (1) summary
      pfam05327
      Location:8373
      RRN3; RNA polymerase I specific transcription initiation factor RRN3
    2. XM_005255376.2XP_005255433.1  RNA polymerase I-specific transcription initiation factor RRN3 isoform X3

      See identical proteins and their annotated locations for XP_005255433.1

      Conserved Domains (1) summary
      pfam05327
      Location:8373
      RRN3; RNA polymerase I specific transcription initiation factor RRN3
    3. XM_011522541.2XP_011520843.1  RNA polymerase I-specific transcription initiation factor RRN3 isoform X2

      See identical proteins and their annotated locations for XP_011520843.1

      Conserved Domains (1) summary
      pfam05327
      Location:16377
      RRN3; RNA polymerase I specific transcription initiation factor RRN3
    4. XM_011522540.3XP_011520842.1  RNA polymerase I-specific transcription initiation factor RRN3 isoform X1

      Conserved Domains (1) summary
      pfam05327
      Location:2381
      RRN3; RNA polymerase I specific transcription initiation factor RRN3

    Reference GRCh38.p12 ALT_REF_LOCI_1

    Genomic

    1. NT_187607.1 Reference GRCh38.p12 ALT_REF_LOCI_1

      Range
      575341..609658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center