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    NES nestin [ Homo sapiens (human) ]

    Gene ID: 10763, updated on 5-Feb-2017
    Official Symbol
    NESprovided by HGNC
    Official Full Name
    nestinprovided by HGNC
    Primary source
    HGNC:HGNC:7756
    See related
    Ensembl:ENSG00000132688 MIM:600915; Vega:OTTHUMG00000034299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Nbla00170
    Summary
    This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
    Orthologs
    Location:
    1q23.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (156668763..156677397, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156638555..156647189, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene uncharacterized LOC101928177 Neighboring gene uncharacterized LOC105371453 Neighboring gene brevican Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene ribosomal RNA adenine dimethylase domain containing 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ21841

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    intermediate filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    embryonic camera-type eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of intermediate filament depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament NAS
    Non-traceable Author Statement
    more info
    PubMed 
    intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012300.1 RefSeqGene

      Range
      5001..13635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006617.1NP_006608.1  nestin

      See identical proteins and their annotated locations for NP_006608.1

      Status: REVIEWED

      Source sequence(s)
      AK025494, AL590666, BC051373
      Consensus CDS
      CCDS1151.1
      UniProtKB/Swiss-Prot
      P48681
      UniProtKB/TrEMBL
      Q9H6U9
      Related
      ENSP00000357206, OTTHUMP00000032198, ENST00000368223, OTTHUMT00000082844
      Conserved Domains (1) summary
      pfam00038
      Location:7312
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      156668763..156677397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      158034765..158043399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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