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    PPM1B protein phosphatase, Mg2+/Mn2+ dependent 1B [ Homo sapiens (human) ]

    Gene ID: 5495, updated on 9-Jul-2017
    Official Symbol
    PPM1Bprovided by HGNC
    Official Full Name
    protein phosphatase, Mg2+/Mn2+ dependent 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:9276
    See related
    Ensembl:ENSG00000138032 MIM:603770; Vega:OTTHUMG00000128757
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP2CB; PP2CBETA; PP2C-beta; PPC2BETAX; PP2C-beta-X
    Summary
    The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2p21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (44168803..44247330)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (44395984..44471570)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723904 Neighboring gene RNA, U6 small nuclear 566, pseudogene Neighboring gene ribosomal protein L12 pseudogene 19 Neighboring gene solute carrier family 3 member 1 Neighboring gene prolyl endopeptidase-like

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    NHGRI GWA Catalog
    • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
      Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
      ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC21657

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    N-terminal protein myristoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of NF-kappaB import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-threonine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    protein phosphatase 1B
    Names
    Ser/Thr protein phosphatase type 2C beta 2 isoform
    protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform
    protein phosphatase 2C-like protein
    NP_001028729.1
    NP_002697.1
    NP_808907.1
    NP_808908.1
    XP_011531238.1
    XP_016859884.1
    XP_016859885.1
    XP_016859886.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011678.1 RefSeqGene

      Range
      4943..70743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001033557.2NP_001028729.1  protein phosphatase 1B isoform 5

      See identical proteins and their annotated locations for NP_001028729.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA742374, DA128532, DQ023510
      Consensus CDS
      CCDS46271.1
      UniProtKB/Swiss-Prot
      O75688
      Related
      ENSP00000387287.3, OTTHUMP00000202394, ENST00000409432.7, OTTHUMT00000327845
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    2. NM_002706.5NP_002697.1  protein phosphatase 1B isoform 1

      See identical proteins and their annotated locations for NP_002697.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA742374, AL833035, BC064381, DA128532
      Consensus CDS
      CCDS1817.1
      UniProtKB/Swiss-Prot
      O75688
      Related
      ENSP00000282412.4, OTTHUMP00000158953, ENST00000282412.8, OTTHUMT00000250672
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    3. NM_177968.3NP_808907.1  protein phosphatase 1B isoform 2

      See identical proteins and their annotated locations for NP_808907.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      DA128532, DQ023508
      Consensus CDS
      CCDS1816.1
      UniProtKB/Swiss-Prot
      O75688
      Related
      ENSP00000367813.2, OTTHUMP00000158954, ENST00000378551.6, OTTHUMT00000250673
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    4. NM_177969.3NP_808908.1  protein phosphatase 1B isoform 3

      See identical proteins and their annotated locations for NP_808908.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AA742374, AL833035, BC012002, DA128532
      Consensus CDS
      CCDS1818.1
      UniProtKB/Swiss-Prot
      O75688
      Related
      ENSP00000326089.4, OTTHUMP00000158955, ENST00000345249.8, OTTHUMT00000250674
      Conserved Domains (1) summary
      pfam07830
      Location:278
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      44168803..44247330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004396.1XP_016859885.1  protein phosphatase 1B isoform X2

    2. XM_017004397.1XP_016859886.1  protein phosphatase 1B isoform X4

    3. XM_017004395.1XP_016859884.1  protein phosphatase 1B isoform X1

    4. XM_011532936.2XP_011531238.1  protein phosphatase 1B isoform X3

      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    RNA

    1. XR_001738794.1 RNA Sequence

      Related
      ENST00000378540.8

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      44325361..44391185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033556.1: Suppressed sequence

      Description
      NM_001033556.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to be falsely primed from an intronic A-tract and may not be complete at the 3' end.
    Support Center