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    BCL6 B-cell CLL/lymphoma 6 [ Homo sapiens (human) ]

    Gene ID: 604, updated on 25-Sep-2016
    Official Symbol
    BCL6provided by HGNC
    Official Full Name
    B-cell CLL/lymphoma 6provided by HGNC
    Primary source
    HGNC:HGNC:1001
    See related
    Ensembl:ENSG00000113916 HPRD:00180; MIM:109565; Vega:OTTHUMG00000156441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCL5; LAZ3; BCL6A; ZNF51; ZBTB27
    Summary
    The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
    Orthologs
    Location:
    3q27
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (187721377..187745725, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (187439165..187463513, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene somatostatin Neighboring gene hCG1645011-like Neighboring gene receptor transporter protein 2 Neighboring gene uncharacterized LOC105374263 Neighboring gene uncharacterized LOC105374264

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    NHGRI GWA Catalog
    Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
    NHGRI GWA Catalog
    Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population.
    NHGRI GWA Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    NHGRI GWA Catalog
    Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of B-cell CLL/lymphoma 6 (BCL6) in human B cells PubMed
    Tat tat HIV-1 Tat upregulates the expression of T-bet, Eomesdermin, Blimp-1, Bcl-6, and Bcl-2 in stimulated but not in unstimulated CD8? T lymphocytes PubMed
    tat HIV-1 Tat upregulates the expression of BCL-6 in Kaposi's sarcoma cells and human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intronic transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    germinal center formation IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    myeloid cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of B cell apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T-helper 2 cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of isotype switching to IgE isotypes IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mast cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cellular component movement IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of histone deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    protein import into nucleus, translocation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of germinal center formation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of memory T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    type 2 immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    B-cell lymphoma 6 protein
    Names
    B-cell lymphoma 5 protein
    B-cell lymphoma 6 protein transcript
    BCL-5
    BCL-6
    cys-his2 zinc finger transcription factor
    lymphoma-associated zinc finger gene on chromosome 3
    protein LAZ-3
    zinc finger and BTB domain-containing protein 27
    zinc finger protein 51
    zinc finger transcription factor BCL6S

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007149.1 RefSeqGene

      Range
      4811..29159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130845.1NP_001124317.1  B-cell lymphoma 6 protein isoform 1

      See identical proteins and their annotated locations for NP_001124317.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a downstream and alternate 5' UTR exon, as compared to variant 1.
      Source sequence(s)
      AW470156, BC146796, BC150184, CN401512
      Consensus CDS
      CCDS3289.1
      UniProtKB/Swiss-Prot
      P41182
      Related
      ENSP00000232014, OTTHUMP00000209897, ENST00000232014, OTTHUMT00000344205
      Conserved Domains (4) summary
      smart00225
      Location:33126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:576596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22126
      BTB; BTB/POZ domain
      pfam13465
      Location:588613
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001134738.1NP_001128210.1  B-cell lymphoma 6 protein isoform 2

      See identical proteins and their annotated locations for NP_001128210.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a coding exon, as compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, as compared to isoform 2.
      Source sequence(s)
      AW337942, BC146796, BC150184, EU883531, Z21943
      Consensus CDS
      CCDS46975.1
      UniProtKB/Swiss-Prot
      P41182
      UniProtKB/TrEMBL
      B5B0A5
      Related
      ENSP00000413122, OTTHUMP00000209900, ENST00000450123, OTTHUMT00000344211
      Conserved Domains (5) summary
      smart00225
      Location:33126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:520540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:518540
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:22126
      BTB; BTB/POZ domain
      pfam13465
      Location:532557
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001706.4NP_001697.2  B-cell lymphoma 6 protein isoform 1

      See identical proteins and their annotated locations for NP_001697.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
      Source sequence(s)
      AI624861, BC146796, BC150184, DB079847
      Consensus CDS
      CCDS3289.1
      UniProtKB/Swiss-Prot
      P41182
      Related
      ENSP00000384371, OTTHUMP00000209895, ENST00000406870, OTTHUMT00000344202
      Conserved Domains (4) summary
      smart00225
      Location:33126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:576596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22126
      BTB; BTB/POZ domain
      pfam13465
      Location:588613
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      187721377..187745725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513062.2XP_011511364.1  

      See identical proteins and their annotated locations for XP_011511364.1

      UniProtKB/Swiss-Prot
      P41182
      Related
      ENSP00000479784, ENST00000621333
      Conserved Domains (5) summary
      smart00225
      Location:33126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:520540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:518540
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:22126
      BTB; BTB/POZ domain
      pfam13465
      Location:532557
      zf-H2C2_2; Zinc-finger double domain
    2. XM_005247694.3XP_005247751.1  

      See identical proteins and their annotated locations for XP_005247751.1

      UniProtKB/Swiss-Prot
      P41182
      Conserved Domains (4) summary
      smart00225
      Location:33126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:576596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22126
      BTB; BTB/POZ domain
      pfam13465
      Location:588613
      zf-H2C2_2; Zinc-finger double domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      187402407..187426738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138931.1: Suppressed sequence

      Description
      NM_138931.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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