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    FLT4 fms related tyrosine kinase 4 [ Homo sapiens (human) ]

    Gene ID: 2324, updated on 22-Apr-2017
    Official Symbol
    FLT4provided by HGNC
    Official Full Name
    fms related tyrosine kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:3767
    See related
    Ensembl:ENSG00000037280 MIM:136352; Vega:OTTHUMG00000130931
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCL; FLT-4; FLT41; LMPH1A; VEGFR3; VEGFR-3
    Summary
    This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5q35.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (180601506..180650298, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180028506..180076624, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex subunit 6 Neighboring gene proteolipid protein 2 (colonic epithelium-enriched) pseudogene Neighboring gene secretoglobin family 3A member 1 Neighboring gene coiled-coil domain containing 86 pseudogene Neighboring gene long intergenic non-protein coding RNA 2222

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular endothelial growth factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vascular endothelial growth factor-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    blood vessel morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to vascular endothelial growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    lymph vessel development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lymphangiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphangiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase C signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vascular endothelial growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of blood vessel remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    respiratory system process IEA
    Inferred from Electronic Annotation
    more info
     
    sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    vasculature development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    vascular endothelial growth factor receptor 3
    Names
    fms-like tyrosine kinase 4
    tyrosine-protein kinase receptor FLT4
    NP_002011.2
    NP_891555.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011536.1 RefSeqGene

      Range
      5001..53119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002020.4NP_002011.2  vascular endothelial growth factor receptor 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_002011.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon compared to variant 1. This results in an isoform (2) with a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AC122714, AY233382, DB455035, X68203
      Consensus CDS
      CCDS43412.1
      UniProtKB/Swiss-Prot
      P35916
      Related
      ENSP00000377016.3, OTTHUMP00000223511, ENST00000393347.7, OTTHUMT00000372538
      Conserved Domains (10) summary
      cd05862
      Location:245329
      Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      cd05863
      Location:352418
      Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
      smart00408
      Location:693755
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:564657
      IG; Immunoglobulin
      smart00410
      Location:238327
      IG_like; Immunoglobulin like
      pfam07679
      Location:678765
      I-set; Immunoglobulin I-set domain
      cd05102
      Location:8371176
      PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
      pfam07714
      Location:8451169
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:138224
      Ig_2; Immunoglobulin domain
      cl11960
      Location:570658
      Ig; Immunoglobulin domain
    2. NM_182925.4NP_891555.2  vascular endothelial growth factor receptor 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_891555.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC122714, AY233383, DB455035, X68203
      Consensus CDS
      CCDS4457.1
      UniProtKB/Swiss-Prot
      P35916
      Related
      ENSP00000261937.6, OTTHUMP00000161539, ENST00000261937.10, OTTHUMT00000253527
      Conserved Domains (10) summary
      cd05862
      Location:245329
      Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      cd05863
      Location:352418
      Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
      smart00408
      Location:693755
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:564657
      IG; Immunoglobulin
      smart00410
      Location:238327
      IG_like; Immunoglobulin like
      pfam07679
      Location:678765
      I-set; Immunoglobulin I-set domain
      cd05102
      Location:8371176
      PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
      pfam07714
      Location:8451169
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:138224
      Ig_2; Immunoglobulin domain
      cl11960
      Location:570658
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      180601506..180650298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009268.1XP_016864757.1  vascular endothelial growth factor receptor 3 isoform X5

    2. XM_017009263.1XP_016864752.1  vascular endothelial growth factor receptor 3 isoform X2

    3. XM_011534478.2XP_011532780.1  vascular endothelial growth factor receptor 3 isoform X1

      Conserved Domains (10) summary
      cd05862
      Location:322406
      Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      cd05863
      Location:429495
      Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
      smart00408
      Location:770832
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:641734
      IG; Immunoglobulin
      smart00410
      Location:315404
      IG_like; Immunoglobulin like
      pfam07679
      Location:755842
      I-set; Immunoglobulin I-set domain
      cd05102
      Location:9141253
      PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
      pfam07714
      Location:9221246
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:215301
      Ig_2; Immunoglobulin domain
      cl11960
      Location:647735
      Ig; Immunoglobulin domain
    4. XM_011534484.2XP_011532786.1  vascular endothelial growth factor receptor 3 isoform X6

      Conserved Domains (10) summary
      cd05862
      Location:92176
      Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      cd05863
      Location:199265
      Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
      smart00408
      Location:540602
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:411504
      IG; Immunoglobulin
      smart00410
      Location:85174
      IG_like; Immunoglobulin like
      pfam07679
      Location:525612
      I-set; Immunoglobulin I-set domain
      cd05102
      Location:6841023
      PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
      pfam07714
      Location:6921016
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:171
      Ig_2; Immunoglobulin domain
      cl11960
      Location:417505
      Ig; Immunoglobulin domain
    5. XM_017009266.1XP_016864755.1  vascular endothelial growth factor receptor 3 isoform X3

    6. XM_017009264.1XP_016864753.1  vascular endothelial growth factor receptor 3 isoform X2

    7. XM_017009265.1XP_016864754.1  vascular endothelial growth factor receptor 3 isoform X2

    8. XM_017009267.1XP_016864756.1  vascular endothelial growth factor receptor 3 isoform X4

    RNA

    1. XR_001742050.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      179460942..179509118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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