SOCS2 suppressor of cytokine signaling 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SOCS2provided by HGNC
Official Full Name: suppressor of cytokine signaling 2provided by HGNC
Primary source: HGNC:HGNC:19382
See related: Ensembl:ENSG00000120833 MIM:605117; AllianceGenome:HGNC:19382
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2
Summary: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression: Broad expression in endometrium (RPKM 13.5), prostate (RPKM 10.5) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (93569969..93626236)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (93551422..93607676)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (93963745..93970521)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging.
Title: Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging.
Inhibition of miR-578 through SOCS2-dependent manner reverses gefitinib resistance in NSCLC cells.
Title: Inhibition of miR-578 through SOCS2-dependent manner reverses gefitinib resistance in NSCLC cells.
SOCS2 inhibits hepatoblastoma metastasis via downregulation of the JAK2/STAT5 signal pathway.
Title: SOCS2 inhibits hepatoblastoma metastasis via downregulation of the JAK2/STAT5 signal pathway.
CTRP6 protects against ferroptosis to drive lung cancer progression and metastasis by destabilizing SOCS2 and augmenting the xCT/GPX4 pathway.
Title: CTRP6 protects against ferroptosis to drive lung cancer progression and metastasis by destabilizing SOCS2 and augmenting the xCT/GPX4 pathway.
MiR-532-3p inhibited the methylation of SOCS2 to suppress the progression of PC by targeting DNMT3A.
Title: MiR-532-3p inhibited the methylation of SOCS2 to suppress the progression of PC by targeting DNMT3A.
Upregulation of SOCS2 causes mitochondrial dysfunction and promotes ferroptosis in pancreatic cancer cells.
Title: Upregulation of SOCS2 causes mitochondrial dysfunction and promotes ferroptosis in pancreatic cancer cells.
circ_0008797 attenuates non-small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR-301a-3p/SOCS2.
Title: circ_0008797 attenuates non-small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR-301a-3p/SOCS2.
miR-3648 promotes lung adenocarcinoma-genesis by inhibiting SOCS2 (suppressor of cytokine signaling 2).
Title: miR-3648 promotes lung adenocarcinoma-genesis by inhibiting SOCS2 (suppressor of cytokine signaling 2).
MicroRNA -196b is related to the overall survival of patients with esophageal squamous cell carcinoma and facilitates tumor progression by regulating SOCS2 (Suppressor Of Cytokine Signaling 2).
Title: MicroRNA -196b is related to the overall survival of patients with esophageal squamous cell carcinoma and facilitates tumor progression by regulating SOCS2 (Suppressor Of Cytokine Signaling 2).
Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.
Title: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.

Submit: New GeneRIF Correction See all GeneRIFs (83)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide analysis of hepatic lipid content in extreme obesity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis identifies 20 loci that influence adult height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Many sequence variants affecting diversity of adult human height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of suppressor of cytokine signaling 2 (SOCS2) in human primary T cells	PubMed
	tat	HIV-1 Tat impairs the IFNgamma-receptor signaling pathway in primary human monocytes at the level of STAT1 activation via Tat-dependent induction of suppressor of cytokine signaling-2 (SOCS-2) activity	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC298718P2 (e-PCR)
- UniSTS:272457

SOCS2_V159 (e-PCR)
- UniSTS:478026

RH80947 (e-PCR)
- UniSTS:83880

D12S2130 (e-PCR)
- UniSTS:29870

RH99191 (e-PCR)
- UniSTS:92860

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables JAK pathway signal transduction adaptor activity	TAS Traceable Author Statement more info	PubMed
enables growth hormone receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables insulin-like growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in growth hormone receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in mammary gland alveolus development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in response to estradiol	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: suppressor of cytokine signaling 2

Names: CIS-2; STAT-induced STAT inhibitor 2; cytokine-inducible SH2 protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270467.2 → NP_001257396.1 suppressor of cytokine signaling 2

See identical proteins and their annotated locations for NP_001257396.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.

Source sequence(s)

AC012085, AI129818, AK313165, BC010399, BJ996504, CD699665, DA709082

Consensus CDS

CCDS9047.1

UniProtKB/Swiss-Prot

A8K3D1, O14508, O14542, O95102, Q9UKS5

UniProtKB/TrEMBL

B5BU82

Related

ENSP00000448815.1, ENST00000549206.5

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
NM_001270468.2 → NP_001257397.1 suppressor of cytokine signaling 2

See identical proteins and their annotated locations for NP_001257397.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.

Source sequence(s)

AI129818, AK313165, BC010399, BJ996504, CD699665, DA490057

Consensus CDS

CCDS9047.1

UniProtKB/Swiss-Prot

A8K3D1, O14508, O14542, O95102, Q9UKS5

UniProtKB/TrEMBL

B5BU82

Related

ENSP00000442898.2, ENST00000536696.6

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
NM_001270469.2 → NP_001257398.1 suppressor of cytokine signaling 2

See identical proteins and their annotated locations for NP_001257398.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.

Source sequence(s)

AI129818, AK313165, BC010399, BJ996504, CD699665, DB054162

Consensus CDS

CCDS9047.1

UniProtKB/Swiss-Prot

A8K3D1, O14508, O14542, O95102, Q9UKS5

UniProtKB/TrEMBL

B5BU82

Related

ENSP00000447161.1, ENST00000549122.5

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
NM_001270470.1 → NP_001257399.1 suppressor of cytokine signaling 2

See identical proteins and their annotated locations for NP_001257399.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) represents the longest transcript. Variants 1-6 encode the same protein.

Source sequence(s)

AI129818, AK313165, BC010399, BJ996504, CD699665, DB054162, DB481261

Consensus CDS

CCDS9047.1

UniProtKB/Swiss-Prot

A8K3D1, O14508, O14542, O95102, Q9UKS5

UniProtKB/TrEMBL

B5BU82

Related

ENSP00000481249.1, ENST00000622746.4

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
NM_001270471.2 → NP_001257400.1 suppressor of cytokine signaling 2

See identical proteins and their annotated locations for NP_001257400.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.

Source sequence(s)

AI129818, AK313165, BC010399, BJ996504, CD699665, DC300183

Consensus CDS

CCDS9047.1

UniProtKB/Swiss-Prot

A8K3D1, O14508, O14542, O95102, Q9UKS5

UniProtKB/TrEMBL

B5BU82

Related

ENSP00000449227.1, ENST00000551556.2

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
NM_003877.5 → NP_003868.1 suppressor of cytokine signaling 2

See identical proteins and their annotated locations for NP_003868.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.

Source sequence(s)

AI129818, AK313165, AL522912, BC010399, BJ996504, CD699665

Consensus CDS

CCDS9047.1

UniProtKB/Swiss-Prot

A8K3D1, O14508, O14542, O95102, Q9UKS5

UniProtKB/TrEMBL

B5BU82

Related

ENSP00000339428.2, ENST00000340600.6

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

93569969..93626236

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017020147.2 → XP_016875636.1 suppressor of cytokine signaling 2 isoform X1

UniProtKB/TrEMBL

B5BU82
XM_017020152.2 → XP_016875641.1 suppressor of cytokine signaling 2 isoform X1

UniProtKB/TrEMBL

B5BU82
XM_047429808.1 → XP_047285764.1 suppressor of cytokine signaling 2 isoform X6

UniProtKB/Swiss-Prot

A8K3D1, O14508, O14542, O95102, Q9UKS5
XM_017020148.3 → XP_016875637.1 suppressor of cytokine signaling 2 isoform X1

UniProtKB/TrEMBL

B5BU82
XM_017020151.2 → XP_016875640.1 suppressor of cytokine signaling 2 isoform X1

UniProtKB/TrEMBL

B5BU82
XM_047429807.1 → XP_047285763.1 suppressor of cytokine signaling 2 isoform X1
XM_017020149.2 → XP_016875638.1 suppressor of cytokine signaling 2 isoform X1

UniProtKB/TrEMBL

B5BU82
XM_011538935.2 → XP_011537237.1 suppressor of cytokine signaling 2 isoform X4

UniProtKB/TrEMBL

B5BU82

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 198

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
XM_011538936.2 → XP_011537238.1 suppressor of cytokine signaling 2 isoform X5

UniProtKB/TrEMBL

B5BU82

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 197

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
XM_011538929.2 → XP_011537231.1 suppressor of cytokine signaling 2 isoform X3

See identical proteins and their annotated locations for XP_011537231.1

UniProtKB/TrEMBL

B5BU82

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03736
Location:158 → 197

SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
XM_017020155.3 → XP_016875644.1 suppressor of cytokine signaling 2 isoform X2

UniProtKB/TrEMBL

B5BU82