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    SLCO2A1 solute carrier organic anion transporter family member 2A1 [ Homo sapiens (human) ]

    Gene ID: 6578, updated on 8-Jun-2017
    Official Symbol
    SLCO2A1provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 2A1provided by HGNC
    Primary source
    HGNC:HGNC:10955
    See related
    Ensembl:ENSG00000174640 MIM:601460; Vega:OTTHUMG00000159745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGT; MATR1; PHOAR2; OATP2A1; SLC21A2
    Summary
    This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]
    Orthologs
    Location:
    3q22.1-q22.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (133932696..134030076, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (133651540..133748920, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RAB6B, member RAS oncogene family Neighboring gene chromosome 3 open reading frame 36 Neighboring gene uncharacterized LOC105374117 Neighboring gene long intergenic non-protein coding RNA 2000

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of solute carrier organic anion transporter family, member 2A1 (SLCO2A1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lipid transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    prostaglandin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    prostaglandin transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    lipid transport TAS
    Traceable Author Statement
    more info
    PubMed 
    prostaglandin transport IEA
    Inferred from Electronic Annotation
    more info
     
    sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sodium-independent organic anion transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    solute carrier organic anion transporter family member 2A1
    Names
    matrin F/G 1
    solute carrier family 21 (prostaglandin transporter), member 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031964.2 RefSeqGene

      Range
      27109..124489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005630.2NP_005621.2  solute carrier organic anion transporter family member 2A1

      See identical proteins and their annotated locations for NP_005621.2

      Status: REVIEWED

      Source sequence(s)
      BC041140, BC051347, BU783445, DA592947, U70867
      Consensus CDS
      CCDS3084.1
      UniProtKB/Swiss-Prot
      Q92959
      Related
      ENSP00000311291.4, OTTHUMP00000216361, ENST00000310926.8, OTTHUMT00000357131
      Conserved Domains (3) summary
      cd06174
      Location:166429
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:441495
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      TIGR00805
      Location:1630
      oat; sodium-independent organic anion transporter

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      133932696..134030076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007075.1XP_016862564.1  solute carrier organic anion transporter family member 2A1 isoform X1

    2. XM_017007077.1XP_016862566.1  solute carrier organic anion transporter family member 2A1 isoform X3

    3. XM_017007076.1XP_016862565.1  solute carrier organic anion transporter family member 2A1 isoform X2

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      133615353..133712732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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