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    HNRNPD heterogeneous nuclear ribonucleoprotein D [ Homo sapiens (human) ]

    Gene ID: 3184, updated on 6-Sep-2017
    Official Symbol
    HNRNPDprovided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Dprovided by HGNC
    Primary source
    HGNC:HGNC:5036
    See related
    Ensembl:ENSG00000138668 MIM:601324; Vega:OTTHUMG00000130290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P37; AUF1; AUF1A; HNRPD; hnRNPD0
    Summary
    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    4q21.22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 4 NC_000004.12 (82353314..82373996, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83274467..83295149, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377308 Neighboring gene uncharacterized LOC105377307 Neighboring gene bridging integrator 2 pseudogene 1 Neighboring gene uncharacterized LOC101928963 Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein D (HNRNPD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Envelope surface glycoprotein gp160, precursor env Depletion of hnRNP D decreases HIV-1 Env synthesis PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein D (HNRNPD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein D (HNRNPD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Depletion of hnRNP D reduces the accumulation of HIV-1 unspliced and singly spliced RNAs and decreases synthesis of HIV-1 Gag in the cytoplasm PubMed
    gag Overexpression of hnRNP D isoform d p37 and isoform c p40 suppress HIV-1 Gag synthesis, while overexpression of isoform a p45 and isoform b p42 increase HIV-1 Gag synthesis PubMed
    gag hnRNP D protein undergoes relocalization to the cytoplasm upon HIV-1 infection and is associated with HIV-1 Gag protein PubMed
    Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein D (HNRNPD), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPD is increased by RRE PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of heterogeneous nuclear ribonucleoprotein D (HNRNPD) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    • AUF1 (hnRNP D0) binds and destabilizes mRNA, organism-specific biosystem (from REACTOME)
      AUF1 (hnRNP D0) binds and destabilizes mRNA, organism-specific biosystemAUF1 (hnRNP D0) dimers bind U-rich regions of AU-rich elements (AREs) in the 3' untranslated regions of mRNAs. The binding causes AUF1 dimers to assemble into higher order tetrameric complexes. Dipho...
    • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
      Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystem (from REACTOME)
      Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystemRNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-eleme...
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    AT DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA 3'-UTR AU-rich region binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    3'-UTR-mediated mRNA destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    RNA catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA metabolic process TAS
    Traceable Author Statement
    more info
     
    RNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nitric oxide IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to putrescine IEA
    Inferred from Electronic Annotation
    more info
     
    cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    circadian regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatocyte dedifferentiation IEA
    Inferred from Electronic Annotation
    more info
     
    liver development IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    mRNA stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of telomerase RNA reverse transcriptase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of telomere capping ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mRNA stability TAS
    Traceable Author Statement
    more info
     
    regulation of telomere maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to rapamycin IEA
    Inferred from Electronic Annotation
    more info
     
    response to sodium phosphate IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    heterogeneous nuclear ribonucleoprotein D0
    Names
    ARE-binding protein AUFI, type A
    AU-rich element RNA binding protein 1, 37kDa
    hnRNP D0

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029103.1 RefSeqGene

      Range
      5001..25683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001003810.1NP_001003810.1  heterogeneous nuclear ribonucleoprotein D0 isoform d

      See identical proteins and their annotated locations for NP_001003810.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame segments, compared to variant 1. The resulting isoform (d), also known as p37, is shorter than isoform a.
      Source sequence(s)
      AF039575, BC023977, BF693760, BG180865, BG180941, BG325979, BM832779
      UniProtKB/Swiss-Prot
      Q14103
      Conserved Domains (3) summary
      cd12575
      Location:80153
      RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins
      cd12583
      Location:164238
      RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
      pfam08143
      Location:6078
      CBFNT; CBFNT (NUC161) domain
    2. NM_002138.3NP_002129.2  heterogeneous nuclear ribonucleoprotein D0 isoform c

      See identical proteins and their annotated locations for NP_002129.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment, compared to variant 1. The resulting isoform (c), also known as p40, is shorter than isoform a.
      Source sequence(s)
      AF039575, BC023977, BF693760, BM825808
      Consensus CDS
      CCDS3590.1
      UniProtKB/Swiss-Prot
      Q14103
      UniProtKB/TrEMBL
      A0A024RDF4
      Related
      ENSP00000313327.6, OTTHUMP00000160799, ENST00000353341.8, OTTHUMT00000252631
      Conserved Domains (3) summary
      cd12575
      Location:99172
      RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins
      cd12583
      Location:183257
      RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
      pfam08143
      Location:6078
      CBFNT; CBFNT (NUC161) domain
    3. NM_031369.2NP_112737.1  heterogeneous nuclear ribonucleoprotein D0 isoform b

      See identical proteins and their annotated locations for NP_112737.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. The resulting isoform (b), also known as p42, is shorter than isoform a.
      Source sequence(s)
      AF039575, BC002401, BC023977, BF693760, BG180865, BG180941, BG325979, BM832779
      Consensus CDS
      CCDS3591.1
      UniProtKB/Swiss-Prot
      Q14103
      UniProtKB/TrEMBL
      A0A024RDB4
      Related
      ENSP00000305860.6, OTTHUMP00000160800, ENST00000352301.8, OTTHUMT00000252632
      Conserved Domains (3) summary
      cd12575
      Location:80153
      RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins
      cd12583
      Location:164238
      RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
      pfam08143
      Location:6078
      CBFNT; CBFNT (NUC161) domain
    4. NM_031370.2NP_112738.1  heterogeneous nuclear ribonucleoprotein D0 isoform a

      See identical proteins and their annotated locations for NP_112738.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a), also known as p45.
      Source sequence(s)
      AF039575, BC002401, BC023977, BF693760, BG180865, BG180941, BM825808, BM832779
      Consensus CDS
      CCDS3592.1
      UniProtKB/Swiss-Prot
      Q14103
      UniProtKB/TrEMBL
      A0A024RDF3
      Related
      ENSP00000313199.7, OTTHUMP00000160798, ENST00000313899.11, OTTHUMT00000252630
      Conserved Domains (3) summary
      cd12575
      Location:99172
      RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins
      cd12583
      Location:183257
      RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
      pfam08143
      Location:6078
      CBFNT; CBFNT (NUC161) domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p7 Primary Assembly

      Range
      82353314..82373996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      83250972..83271667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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