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    XPOT exportin for tRNA [ Homo sapiens (human) ]

    Gene ID: 11260, updated on 17-Nov-2017
    Official Symbol
    XPOTprovided by HGNC
    Official Full Name
    exportin for tRNAprovided by HGNC
    Primary source
    HGNC:HGNC:12826
    See related
    Ensembl:ENSG00000184575 MIM:603180; Vega:OTTHUMG00000168794
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    XPO3
    Summary
    This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 36.4), brain (RPKM 13.8) and 25 other tissues See more
    Orthologs
    Location:
    12q14.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (64404350..64451125)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (64798153..64842464)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 56 Neighboring gene ATPase H+ transporting V1 subunit E1 pseudogene 3 Neighboring gene ribosomal protein S11 pseudogene 6 Neighboring gene mitochondrial ribosomal protein S25 pseudogene Neighboring gene TANK binding kinase 1 Neighboring gene uncharacterized LOC105369803

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Exportin-t-mediated nuclear-cytoplasmic transport of the eEF1A/Nef complexes in monocyte-derived macrophages is invloved in the inhibition of apoptosis triggered by stress PubMed

    Go to the HIV-1, Human Interaction Database

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • tRNA processing, organism-specific biosystem (from REACTOME)
      tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
    • tRNA processing in the nucleus, organism-specific biosystem (from REACTOME)
      tRNA processing in the nucleus, organism-specific biosystemGenes encoding transfer RNAs are transcribed in the nucleus by RNA polymerase III. (Distinct processes of transcription and processing also occur in mitochondria.) The initial transcripts, pre-tRNAs,...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Ran GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    tRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    tRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tRNA export from nucleus TAS
    Traceable Author Statement
    more info
     
    tRNA re-export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    nuclear matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    exportin-T
    Names
    exportin(tRNA)
    exportin, tRNA (nuclear export receptor for tRNAs)
    tRNA exportin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007235.5NP_009166.2  exportin-T

      See identical proteins and their annotated locations for NP_009166.2

      Status: REVIEWED

      Source sequence(s)
      AC135279, AK292884, BC020569, BI457849, CR979468
      Consensus CDS
      CCDS31852.1
      UniProtKB/Swiss-Prot
      O43592
      Related
      ENSP00000327821.5, OTTHUMP00000239487, ENST00000332707.9
      Conserved Domains (2) summary
      smart00913
      Location:2188
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:100247
      Xpo1; Exportin 1-like protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      64404350..64451125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018748.1XP_016874237.1  exportin-T isoform X1

      UniProtKB/Swiss-Prot
      O43592
      Conserved Domains (2) summary
      smart00913
      Location:2188
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:100247
      Xpo1; Exportin 1-like protein

    RNA

    1. XR_944484.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      64765247..64809559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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