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    FOXO3 forkhead box O3 [ Homo sapiens (human) ]

    Gene ID: 2309, updated on 21-May-2017
    Official Symbol
    FOXO3provided by HGNC
    Official Full Name
    forkhead box O3provided by HGNC
    Primary source
    HGNC:HGNC:3821
    See related
    Ensembl:ENSG00000118689 MIM:602681; Vega:OTTHUMG00000015327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
    Summary
    This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    6q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (108559823..108684769)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (108881026..109005972)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene AFG1 like ATPase Neighboring gene uncharacterized LOC105377932 Neighboring gene translocase of outer mitochondrial membrane 5 homolog (yeast) pseudogene Neighboring gene RNA, U6 small nuclear 770, pseudogene Neighboring gene SUMO2 pseudogene 8 Neighboring gene uncharacterized LOC107986629 Neighboring gene long intergenic non-protein coding RNA 222

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
    NHGRI GWA Catalog
    Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
    NHGRI GWA Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of forkhead box O3 (FOXO3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat expression in Jurkat T cells increases the amount and the translocation of FOXO3a from the cytoplasm to the nucleus, indicating that FOXO3a is no longer phosphorylated PubMed
    Vpr vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
    vpr HIV-1 Vpr inhibits insulin- and Akt-induced cytoplasmic translocation of Foxo3a, a subtype of the forkhead transcription factors PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC12739, MGC31925, DKFZp781A0677

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    core promoter binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription cofactor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    antral ovarian follicle growth IEA
    Inferred from Electronic Annotation
    more info
     
    brain morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to beta-amyloid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to corticosterone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    initiation of primordial ovarian follicle growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuronal stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    oocyte maturation IEA
    Inferred from Electronic Annotation
    more info
     
    ovulation from ovarian follicle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of hydrogen peroxide-mediated programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of reactive oxygen species biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of neural precursor cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to dexamethasone IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    response to water-immersion restraint stress IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    forkhead box protein O3
    Names
    forkhead box O3A
    forkhead homolog (rhabdomyosarcoma) like 1
    forkhead in rhabdomyosarcoma-like 1
    forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001455.3NP_001446.1  forkhead box protein O3

      See identical proteins and their annotated locations for NP_001446.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' end and represents the longer transcript compared to variant 2. Both variants encode the same protein.
      Source sequence(s)
      AF032886, AK024103, AL096818, AL365509, CA389775
      Consensus CDS
      CCDS5068.1
      UniProtKB/Swiss-Prot
      O43524
      Related
      ENSP00000385824.1, ENST00000406360.1
      Conserved Domains (3) summary
      cd00059
      Location:157237
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16675
      Location:433508
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:606644
      FOXO-TAD; Transactivation domain of FOXO protein family
    2. NM_201559.2NP_963853.1  forkhead box protein O3

      See identical proteins and their annotated locations for NP_963853.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AK024103, AL096818, AL365509, BC020227, CD101760
      Consensus CDS
      CCDS5068.1
      UniProtKB/Swiss-Prot
      O43524
      Related
      ENSP00000339527.6, OTTHUMP00000016944, ENST00000343882.10, OTTHUMT00000041722
      Conserved Domains (3) summary
      cd00059
      Location:157237
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16675
      Location:433508
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:606644
      FOXO-TAD; Transactivation domain of FOXO protein family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      108559823..108684769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266867.4XP_005266924.1  forkhead box protein O3 isoform X2

      Conserved Domains (3) summary
      pfam16675
      Location:244319
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:417455
      FOXO-TAD; Transactivation domain of FOXO protein family
      cl00061
      Location:1750
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    2. XM_011535626.1XP_011533928.1  forkhead box protein O3 isoform X1

      Conserved Domains (3) summary
      pfam16675
      Location:266341
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:439477
      FOXO-TAD; Transactivation domain of FOXO protein family
      cl00061
      Location:4072
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    3. XM_017010585.1XP_016866074.1  forkhead box protein O3 isoform X2

      Conserved Domains (3) summary
      pfam16675
      Location:244319
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:417455
      FOXO-TAD; Transactivation domain of FOXO protein family
      cl00061
      Location:1750
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    4. XM_017010586.1XP_016866075.1  forkhead box protein O3 isoform X3

      UniProtKB/Swiss-Prot
      O43524
      Conserved Domains (2) summary
      pfam16675
      Location:213288
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:386424
      FOXO-TAD; Transactivation domain of FOXO protein family
    5. XM_011535628.2XP_011533930.1  forkhead box protein O3 isoform X3

      See identical proteins and their annotated locations for XP_011533930.1

      UniProtKB/Swiss-Prot
      O43524
      Conserved Domains (2) summary
      pfam16675
      Location:213288
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:386424
      FOXO-TAD; Transactivation domain of FOXO protein family
    6. XM_011535629.2XP_011533931.1  forkhead box protein O3 isoform X3

      See identical proteins and their annotated locations for XP_011533931.1

      UniProtKB/Swiss-Prot
      O43524
      Conserved Domains (2) summary
      pfam16675
      Location:213288
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:386424
      FOXO-TAD; Transactivation domain of FOXO protein family
    7. XM_005266868.3XP_005266925.1  forkhead box protein O3 isoform X3

      See identical proteins and their annotated locations for XP_005266925.1

      UniProtKB/Swiss-Prot
      O43524
      Related
      ENSP00000446316.1, ENST00000540898.1
      Conserved Domains (2) summary
      pfam16675
      Location:213288
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:386424
      FOXO-TAD; Transactivation domain of FOXO protein family

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      109143966..109268930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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