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    XPO1 exportin 1 [ Homo sapiens (human) ]

    Gene ID: 7514, updated on 23-Apr-2017
    Official Symbol
    XPO1provided by HGNC
    Official Full Name
    exportin 1provided by HGNC
    Primary source
    HGNC:HGNC:12825
    See related
    Ensembl:ENSG00000082898 MIM:602559; Vega:OTTHUMG00000152316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    emb; CRM1; exp1
    Summary
    This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]
    Orthologs
    Location:
    2p15
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (61477934..61538522, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (61705069..61765440, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 34 Neighboring gene small nucleolar RNA, H/ACA box 70B Neighboring gene uncharacterized LOC105377633 Neighboring gene proteasome 26S subunit, non-ATPase 12 pseudogene Neighboring gene ribosomal protein S29 pseudogene 10

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of exportin 1 (CRM1 homolog; XPO1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Human CRM1 exports gag mRNA to the cytoplasm more efficiently than rat CRM1 in rat cells, leading to efficient processing of Gag proteins and particle formation PubMed
    gag Mouse-human CRM1 chimera analysis reveals that the amino-acid residues 146-444 of human CRM1 are important for increased HIV-1 titers in mouse cells. Three residues P411/M412/F414 are critical for human CRM1 function PubMed
    gag Human CRM1 increases HIV-1 Gag production in mouse cells. Human CRM1 and SRp40 increase the amount of unspliced HIV-1 RNA and have a more-than-additive effect on HIV-1 titers in mouse cells PubMed
    gag Human CRM1 enhances HIV-1 MA-dependent Gag membrane targeting in mouse cells PubMed
    gag Expression of CRM1 enhances Gag production 10-15 fold in rat macrophages, but only marginally in rat T cells. Expression of both CRM1 and CycT1 factors synergistically enhances Gag production to levels approximately 10-40% of those detected in human cells PubMed
    gag HIV-1 Matrix contains a nuclear export signal (amino acids 15-32) which is recognized by exportin 1 (CRM1; XPO1) and is important for nucleocytoplasmic shuttling of HIV-1 Gag and genomic RNA to the cytoplasm by exportin 1 PubMed
    Rev rev A dimeric CRM1-RanGTP complex binds a Rev-RRE complex to export the Rev-RRE complex from the nuclear to the cytoplasm in cells PubMed
    rev Computational molecular docking, alanine scanning, clustering, and evolutionary analysis reveal the interaction of DDX3 with HIV-1 Rev-CRM1-RanGTP complex PubMed
    rev Co-immunoprecipitation analysis demonstrates that endogenous RBM14 associates with HIV-1 Rev, XPO1, and p54NRB in cells PubMed
    rev The CRM1 dimer interface, including residues T346, P411, M412, F414, R474, E478, and H481, facilitates cooperative assembly with the Rev-RRE complex PubMed
    rev CRM1-mediated nuclear export of Rev involves interactions of CRM1 with RanGTP, RanBP1 and RanGEF PubMed
    rev CRM1 interacts with the nuclear export signal of Rev and acts as a bridge between Rev and nuclear pore proteins PubMed
    rev Nuclear export of Rev is dependent on its activation domain which encodes a nuclear export signal (amino acids 75-83) PubMed
    rev The addition of a second NES to HIV-1 Rev or a second RRE to Rev-dependent transcripts rescues HIV-1 virion production in murine cells independently of human CRM1 PubMed
    rev HIV-1 Rev co-localizes with CRM1 at the HIV-1 transcription site in the nucleus PubMed
    rev Human CRM1 rescues RRE/Rev-dependent HIV-1 virion production in mouse cells PubMed
    rev Rev recruitment of CRM1 to HIV-1 mRNA is sufficient to mediate nuclear export of incompletely spliced HIV-1 mRNA PubMed
    rev Ratjadone A (myxobacterial metabolite) interacts with CRM1 to inhibit the Rev-dependent HIV-1 RNA nuclear export PubMed
    rev Eukaryotic initiation factor 5A (eIF-5A) mediates the binding of CRM1 to Rev PubMed
    rev Interaction of CRM1 with nucleoporins Nup42 and Nup159 results in the release of Rev from CRM1 PubMed
    rev During Rev-mediated nuclear export of HIV-1 mRNA, Rev interacts directly with the nucleocytoplasmic mRNA-transport system PubMed
    rev Excess CRM1 may downregulate Rev-mediated RNA export by sequestering Rev to a subnucleolar structure PubMed
    rev Nuclear retention and co-localization of Rev and CRM1 is caused by down-modulation of GAP-associated tyrosine phosphoprotein p62 (Sam68), suggesting Sam68 is directly involved in the CRM1-mediated Rev nuclear export pathway PubMed
    rev HIV-1 Rev interacting protein, exportin 1 (XPO1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    rev The HEAT repeat helix 9A domain (residues 402-423) of CRM1 serves as an effective cofactor for HIV-1 Rev function in higher primates PubMed
    rev Three specific domains (residues 89-123, 405-593, and 594-670) of NF90 promote Rev-RRE mediated nuclear export of Gag mRNA, which is dependent on CRM1 function PubMed
    rev HIV-1 Rev/CRM1 export complexes are observed in nucleoli by cotransfection with CFP/YFP pairs of the proteins on a large three-dimensional set of fixed cells, with Rev/CRM1 colocalization in nucleoli decreasing exponentially after addition of leptomycin B PubMed
    rev Studies suggest Rev is necessary and sufficient for the accumulation of incompletely spliced HIV RNAs at nuclear pores while CRM1 is required for translocation across the nuclear pore complex PubMed
    rev Rev-Rev interactions (multimerization) are enhanced by CRM1 PubMed
    rev The C-terminal region of Rev (amino acids 86-116) plays a role in enhancing the interaction of Rev with CRM1 PubMed
    rev CRM1 is involved in the binding of Rev to yeast Rip1 and hRip/Rab, which is involved in Rev-mediated nuclear export of HIV-1 mRNA PubMed
    rev CRM1 interacts with FG-repeat-containing nuclear pore proteins during nuclear export of Rev PubMed
    Tat tat Exportin 1 (XPO1, CRM1 homolog) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    tat Interaction of HIV-1 Tat with XPO1 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
    Vpr vpr Nuclear export of HIV-1 Vpr by exportin-1 is required for efficient HIV replication in tissue macrophages and is important for Vpr incorporation into virions PubMed
    vpr HIV-1 Vpr contains a nuclear export signal within amino acids 1-71 that is sensitive to Leptomycin B, suggesting it is recognized by CRM1 (exportin 1) PubMed
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with exportin 1 (XPO1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    capsid gag Human CRM1 and SRp40 have a more-than-additive effect on HIV-1 CA production in mouse cells PubMed
    matrix gag Human CRM1 enhances HIV-1 MA-dependent Gag membrane targeting in mouse cells PubMed
    gag HIV-1 Matrix contains a nuclear export signal (amino acids 15-32) which is recognized by exportin 1 (CRM1; XPO1) and is important for nucleocytoplasmic shuttling of HIV-1 Gag and genomic RNA to the cytoplasm by exportin 1 PubMed

    Go to the HIV-1, Human Interaction Database

    • Canonical NF-kappaB pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical NF-kappaB pathway, organism-specific biosystem
      Canonical NF-kappaB pathway
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      Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem
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      Infectious disease, organism-specific biosystem
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      Mitotic G2-G2/M phases, organism-specific biosystem
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    • RNA transport, organism-specific biosystem (from KEGG)
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    • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
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    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
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      Signaling events mediated by HDAC Class I, organism-specific biosystem
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    • Signaling events mediated by HDAC Class II, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class II, organism-specific biosystem
      Signaling events mediated by HDAC Class II
    • Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem
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    • eIF5A regulation in response to inhibition of the nuclear export system, organism-specific biosystem (from WikiPathways)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp686B1823

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Ran GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear export signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleocytoplasmic transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transporter activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    intracellular transport of virus TAS
    Traceable Author Statement
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mRNA stability TAS
    Traceable Author Statement
    more info
     
    regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ribosomal small subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ribosomal subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sister chromatid cohesion TAS
    Traceable Author Statement
    more info
     
    viral process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Cajal body IEA
    Inferred from Electronic Annotation
    more info
     
    annulate lamellae IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    intracellular ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    exportin-1
    Names
    chromosome region maintenance 1 homolog
    chromosome region maintenance 1 protein homolog
    exportin 1 (CRM1 homolog, yeast)
    exportin-1 (required for chromosome region maintenance)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003400.3NP_003391.1  exportin-1

      See identical proteins and their annotated locations for NP_003391.1

      Status: REVIEWED

      Source sequence(s)
      AK124769, AL833550, BC032847, BX492941, BX643790, BX647758, BX954288, CR749840, Y08614
      Consensus CDS
      CCDS33205.1
      UniProtKB/Swiss-Prot
      O14980
      UniProtKB/TrEMBL
      B3KWD0
      Related
      ENSP00000384863.2, OTTHUMP00000201470, ENST00000401558.6, OTTHUMT00000325872
      Conserved Domains (4) summary
      smart00913
      Location:46112
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:151044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:123268
      Xpo1; Exportin 1-like protein
      pfam08767
      Location:7091026
      CRM1_C; CRM1 C terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      61477934..61538522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533097.1XP_011531399.1  exportin-1 isoform X1

      See identical proteins and their annotated locations for XP_011531399.1

      UniProtKB/Swiss-Prot
      O14980
      Related
      ENSP00000385942.2, OTTHUMP00000201496, ENST00000404992.6, OTTHUMT00000325919
      Conserved Domains (4) summary
      smart00913
      Location:46112
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:151044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:123268
      Xpo1; Exportin 1-like protein
      pfam08767
      Location:7091026
      CRM1_C; CRM1 C terminal
    2. XM_005264544.1XP_005264601.1  exportin-1 isoform X2

      Conserved Domains (4) summary
      smart00913
      Location:46112
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:151029
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:110253
      Xpo1; Exportin 1-like protein
      pfam08767
      Location:6941011
      CRM1_C; CRM1 C terminal
    3. XM_011533099.2XP_011531401.1  exportin-1 isoform X4

      See identical proteins and their annotated locations for XP_011531401.1

      Conserved Domains (4) summary
      smart00913
      Location:1046
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:10978
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:57202
      Xpo1; Exportin 1-like protein
      pfam08767
      Location:643960
      CRM1_C; CRM1 C terminal
    4. XM_006712094.2XP_006712157.1  exportin-1 isoform X1

      See identical proteins and their annotated locations for XP_006712157.1

      UniProtKB/Swiss-Prot
      O14980
      Conserved Domains (4) summary
      smart00913
      Location:46112
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:151044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:123268
      Xpo1; Exportin 1-like protein
      pfam08767
      Location:7091026
      CRM1_C; CRM1 C terminal
    5. XM_011533098.1XP_011531400.1  exportin-1 isoform X3

      See identical proteins and their annotated locations for XP_011531400.1

      Conserved Domains (4) summary
      smart00913
      Location:46112
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:15999
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:123268
      Xpo1; Exportin 1-like protein
      pfam08767
      Location:664981
      CRM1_C; CRM1 C terminal
    6. XM_005264546.1XP_005264603.1  exportin-1 isoform X5

      See identical proteins and their annotated locations for XP_005264603.1

      Conserved Domains (3) summary
      COG5101
      Location:1913
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:1137
      Xpo1; Exportin 1-like protein
      pfam08767
      Location:578895
      CRM1_C; CRM1 C terminal

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      61635341..61695639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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