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    NRGN neurogranin [ Homo sapiens (human) ]

    Gene ID: 4900, updated on 12-Mar-2017
    Official Symbol
    NRGNprovided by HGNC
    Official Full Name
    neurograninprovided by HGNC
    Primary source
    HGNC:HGNC:8000
    See related
    Ensembl:ENSG00000154146 MIM:602350; Vega:OTTHUMG00000165928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RC3; hng
    Summary
    Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11q24.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (124739933..124747206)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124609829..124617102)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene sialic acid acetylesterase Neighboring gene sperm autoantigenic protein 17 Neighboring gene uncharacterized LOC107984405 Neighboring gene uncharacterized LOC101929340 Neighboring gene V-set and immunoglobulin domain containing 2 Neighboring gene endothelial cell adhesion molecule

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    NHGRI GWA Catalog
    Common variants conferring risk of schizophrenia.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    telencephalon development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine head IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    neurogranin
    Names
    calmodulin-binding protein
    neurogranin (protein kinase C substrate, RC3)
    ng
    protein kinase C substrate

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126181.1NP_001119653.1  neurogranin

      See identical proteins and their annotated locations for NP_001119653.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice acceptor site in a 3'UTR exon.
      Source sequence(s)
      BC002835, BM923818, DB474181
      Consensus CDS
      CCDS8451.1
      UniProtKB/Swiss-Prot
      Q92686
      UniProtKB/TrEMBL
      A0A024R3M7
      Related
      ENSP00000399591, OTTHUMP00000231529, ENST00000412681, OTTHUMT00000387078
      Conserved Domains (1) summary
      smart00015
      Location:3247
      IQ; Calmodulin-binding motif
    2. NM_006176.2NP_006167.1  neurogranin

      See identical proteins and their annotated locations for NP_006167.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice acceptor site in a 3'UTR exon.
      Source sequence(s)
      BC002835, DB474181, Y09689
      Consensus CDS
      CCDS8451.1
      UniProtKB/Swiss-Prot
      Q92686
      UniProtKB/TrEMBL
      A0A024R3M7
      Related
      ENSP00000284292, OTTHUMP00000231530, ENST00000284292, OTTHUMT00000387079
      Conserved Domains (1) summary
      smart00015
      Location:3247
      IQ; Calmodulin-binding motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      124739933..124747206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      124495926..124503199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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