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    TAF15 TATA-box binding protein associated factor 15 [ Homo sapiens (human) ]

    Gene ID: 8148, updated on 8-Oct-2017
    Official Symbol
    TAF15provided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 15provided by HGNC
    Primary source
    HGNC:HGNC:11547
    See related
    Ensembl:ENSG00000270647 MIM:601574; Vega:OTTHUMG00000188384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Npl3; RBP56; TAF2N; TAFII68
    Summary
    This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
    Orthologs
    Location:
    17q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (35809455..35847242)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34136459..34174246)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene growth arrest specific 2 like 2 Neighboring gene uncharacterized LOC107985067 Neighboring gene chromosome 17 open reading frame 50 Neighboring gene matrix metallopeptidase 28 Neighboring gene probable ribosome biogenesis protein RLP24 pseudogene Neighboring gene HEAT repeat containing 9 Neighboring gene uncharacterized LOC105371744 Neighboring gene C-C motif chemokine ligand 5

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa (TAF15) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
    tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
    tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
    tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
    tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    TATA-binding protein-associated factor 2N
    Names
    RBP56/CSMF fusion
    TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)
    TATA box-binding protein-associated factor 2N (RNA-binding protein 56)
    TBP-associated factor 15

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023279.1 RefSeqGene

      Range
      4972..42759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003487.3NP_003478.1  TATA-binding protein-associated factor 2N isoform 2

      See identical proteins and their annotated locations for NP_003478.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1, that results in a shorter protein (isoform 2).
      Source sequence(s)
      AI351964, AK313223, BC039129, DB166653
      Consensus CDS
      CCDS59279.1
      UniProtKB/Swiss-Prot
      Q92804
      Related
      ENSP00000474609.1, OTTHUMP00000276478, ENST00000604841.5, OTTHUMT00000477052
      Conserved Domains (4) summary
      COG0724
      Location:219316
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:229314
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      sd00025
      Location:355376
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:351381
      zf-RanBP; Zn-finger in Ran binding protein and others
    2. NM_139215.2NP_631961.1  TATA-binding protein-associated factor 2N isoform 1

      See identical proteins and their annotated locations for NP_631961.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI351964, AK314194, BC046099, BG403710, DB166653
      Consensus CDS
      CCDS32623.1
      UniProtKB/Swiss-Prot
      Q92804
      Related
      ENSP00000474096.1, OTTHUMP00000276473, ENST00000605844.5, OTTHUMT00000477043
      Conserved Domains (5) summary
      cd12535
      Location:232317
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      sd00025
      Location:358379
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:354384
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam15991
      Location:1124
      G_path_suppress; G-protein pathway suppressor
      cl25887
      Location:136315
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      35809455..35847242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525315.1XP_011523617.1  TATA-binding protein-associated factor 2N isoform X1

      See identical proteins and their annotated locations for XP_011523617.1

      Conserved Domains (4) summary
      COG0724
      Location:131228
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:141226
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      sd00025
      Location:267288
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:263293
      zf-RanBP; Zn-finger in Ran binding protein and others
    2. XM_017025181.1XP_016880670.1  TATA-binding protein-associated factor 2N isoform X2

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      43987..81774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      34201011..34238813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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