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    SNAP23 synaptosome associated protein 23 [ Homo sapiens (human) ]

    Gene ID: 8773, updated on 6-May-2018
    Official Symbol
    SNAP23provided by HGNC
    Official Full Name
    synaptosome associated protein 23provided by HGNC
    Primary source
    HGNC:HGNC:11131
    See related
    Ensembl:ENSG00000092531 MIM:602534; Vega:OTTHUMG00000130625
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNAP-23; SNAP23A; SNAP23B; HsT17016
    Summary
    Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 25.6), appendix (RPKM 23.5) and 25 other tissues See more
    Orthologs
    See SNAP23 in Genome Data Viewer
    Location:
    15q15.1-q15.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (42491244..42533061)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42783442..42825259)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene calpain 3 Neighboring gene uncharacterized LOC105370794 Neighboring gene zinc finger protein 106 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene myosin light chain 12B pseudogene 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
      Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
      Clathrin derived vesicle budding, organism-specific biosystemThere at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the cl...
    • ER-Phagosome pathway, organism-specific biosystem (from REACTOME)
      ER-Phagosome pathway, organism-specific biosystemThe other TAP-dependent cross-presentation mechanism in phagocytes is the endoplasmic reticulum (ER)-phagosome model. Desjardins proposed that ER is recruited to the cell surface, where it fuses wit...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Platelet activation, organism-specific biosystem (from KEGG)
      Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
    • SNARE interactions in vesicular transport, organism-specific biosystem (from KEGG)
      SNARE interactions in vesicular transport, organism-specific biosystem
      SNARE interactions in vesicular transport
    • SNARE interactions in vesicular transport, conserved biosystem (from KEGG)
      SNARE interactions in vesicular transport, conserved biosystem
      SNARE interactions in vesicular transport
    • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
      Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
      trans-Golgi Network Vesicle Budding, organism-specific biosystemAfter passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membran...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
    Traceable Author Statement
    more info
     
    exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    histamine secretion by mast cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane fusion TAS
    Traceable Author Statement
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    post-Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    vesicle targeting TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    azurophil granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    focal adhesion HDA PubMed 
    mast cell granule IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    specific granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    specific granule membrane TAS
    Traceable Author Statement
    more info
     
    tertiary granule membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    synaptosomal-associated protein 23
    Names
    synaptosomal-associated protein, 23kD
    synaptosomal-associated protein, 23kDa
    synaptosome associated protein 23kDa
    vesicle-membrane fusion protein SNAP-23

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003825.3NP_003816.2  synaptosomal-associated protein 23 isoform SNAP23A

      See identical proteins and their annotated locations for NP_003816.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript, containing eight exons and encoding the full-length isoform (SNAP23A).
      Source sequence(s)
      AK290152, BC022890, BM782600, DA882401
      Consensus CDS
      CCDS10087.1
      UniProtKB/Swiss-Prot
      O00161
      UniProtKB/TrEMBL
      A8K287
      Related
      ENSP00000249647.3, OTTHUMP00000161203, ENST00000249647.7, OTTHUMT00000253111
      Conserved Domains (3) summary
      cd15884
      Location:149207
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86147
      SNAP-25; SNAP-25 family
    2. NM_130798.2NP_570710.1  synaptosomal-associated protein 23 isoform SNAP23B

      See identical proteins and their annotated locations for NP_570710.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks internal exon 6 but maintains the same reading frame as compared to transcript variant 1. It encodes an isoform (SNAP23B) which is missing 53 aa as compared to the full-length isoform (SNAP23A) encoded by transcript variant 1. The missing region is required for nonspecific binding of the protein to plasma membranes, indicating a functional difference between isoforms SNAP23A and SNAP23B.
      Source sequence(s)
      AK290152, BC022890, BM782600, DA650133, DA882401
      Consensus CDS
      CCDS10088.1
      UniProtKB/Swiss-Prot
      O00161
      UniProtKB/TrEMBL
      A0A024R9R8, A8K287
      Related
      ENSP00000207062.1, ENST00000349777.5
      Conserved Domains (2) summary
      cd15884
      Location:96154
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cl22856
      Location:975
      SNARE; SNARE motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

      Range
      42491244..42533061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022694.1XP_016878183.1  synaptosomal-associated protein 23 isoform X3

    2. XM_006720725.3XP_006720788.1  synaptosomal-associated protein 23 isoform X2

      See identical proteins and their annotated locations for XP_006720788.1

      Conserved Domains (3) summary
      cd15884
      Location:160218
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100158
      SNAP-25; SNAP-25 family
    3. XM_017022692.2XP_016878181.1  synaptosomal-associated protein 23 isoform X1

    4. XM_017022693.2XP_016878182.1  synaptosomal-associated protein 23 isoform X3

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