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    RPS4X ribosomal protein S4, X-linked [ Homo sapiens (human) ]

    Gene ID: 6191, updated on 25-May-2017
    Official Symbol
    RPS4Xprovided by HGNC
    Official Full Name
    ribosomal protein S4, X-linkedprovided by HGNC
    Primary source
    HGNC:HGNC:10424
    See related
    Ensembl:ENSG00000198034 MIM:312760; Vega:OTTHUMG00000021813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S4; CCG2; RPS4; SCAR; SCR10; DXS306
    Summary
    Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    Xq13.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) X NC_000023.11 (72272603..72277291, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (71492453..71497141, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 388, pseudogene Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4 Neighboring gene ERCC excision repair 6 like, spindle assembly checkpoint helicase Neighboring gene uncharacterized LOC105373250 Neighboring gene Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 Neighboring gene histone deacetylase 8 Neighboring gene RNA, U2 small nuclear 68, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify X-linked isoform of ribosomal protein S4 (RPS4X), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify X-linked isoform of ribosomal protein S4 (RPS4X), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify X-linked isoform of ribosomal protein S4 (RPS4X), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify X-linked isoform of ribosomal protein S4 (RPS4X), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, ribosomal protein S4, X-linked (RPS4X), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ40595

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    rRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural constituent of ribosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    SRP-dependent cotranslational protein targeting to membrane TAS
    Traceable Author Statement
    more info
     
    multicellular organism development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
    Traceable Author Statement
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rRNA processing TAS
    Traceable Author Statement
    more info
     
    translation IC
    Inferred by Curator
    more info
    PubMed 
    translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translational initiation TAS
    Traceable Author Statement
    more info
     
    viral transcription TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    polysome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    40S ribosomal protein S4, X isoform
    Names
    cell cycle gene 2
    ribosomal protein S4X isoform
    single copy abundant mRNA protein
    single-copy abundant mRNA
    small ribosomal subunit protein eS4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012524.1 RefSeqGene

      Range
      5001..9689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007.4NP_000998.1  40S ribosomal protein S4, X isoform X isoform

      See identical proteins and their annotated locations for NP_000998.1

      Status: REVIEWED

      Source sequence(s)
      AL135749
      Consensus CDS
      CCDS14418.1
      UniProtKB/Swiss-Prot
      P62701
      UniProtKB/TrEMBL
      B2R491
      Related
      ENSP00000362744.4, OTTHUMP00000023537, ENST00000316084.9, OTTHUMT00000057188
      Conserved Domains (6) summary
      PLN00036
      Location:1260
      PLN00036; 40S ribosomal protein S4; Provisional
      cd00165
      Location:51112
      S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...
      cd06087
      Location:175229
      KOW_RPS4; KOW motif of Ribosomal Protein S4 (RPS4)
      pfam00900
      Location:95169
      Ribosomal_S4e; Ribosomal family S4e
      pfam08071
      Location:339
      RS4NT; RS4NT (NUC023) domain
      pfam16121
      Location:212259
      40S_S4_C; 40S ribosomal protein S4 C-terminus

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p7 Primary Assembly

      Range
      72272603..72277291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      71385460..71390151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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