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    DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 [ Homo sapiens (human) ]

    Gene ID: 3337, updated on 6-Sep-2017
    Official Symbol
    DNAJB1provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B1provided by HGNC
    Primary source
    HGNC:HGNC:5270
    See related
    Ensembl:ENSG00000132002 MIM:604572; Vega:OTTHUMG00000183289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Hdj1; Sis1; HSPF1; Hsp40; RSPH16B
    Summary
    This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    19p13.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (14514764..14529821, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14625581..14640087, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene prostaglandin E receptor 1 Neighboring gene GIPC PDZ domain containing family member 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 15 Neighboring gene microRNA 639 Neighboring gene trans-2,3-enoyl-CoA reductase Neighboring gene NADH:ubiquinone oxidoreductase subunit B7 Neighboring gene RNA, 7SL, cytoplasmic 337, pseudogene Neighboring gene C-type lectin domain containing 17A

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Subtype C Nef upregulates the expression of Hsp40 in HIV-1 infected CEM cells and enhances the increased translocation of Hsp40 into the nucleus PubMed
    nef HIV-1 subtype C Nef interacts with Hsp40 in immunoprecipitation and immunofluorescence staining experiments PubMed
    nef HIV-1 Nef interacts with Hsp40, leading to increased Hsp40 translocation to the nucleus of infected cells and facilitation of viral gene expression by complex formation of Hsp40 with the cdk9-associated transcription complex PubMed
    Tat tat HIV-1 Tat specifically associates with DNAJB1 promoter to upregulate DNAJB1 expression in T cells PubMed
    capsid gag HSP40B1 (DNAJB1) inhibits HIV-1 production as measured by the level of viral p24 capsid in the culture supernatant PubMed

    Go to the HIV-1, Human Interaction Database

    • Attenuation phase, organism-specific biosystem (from REACTOME)
      Attenuation phase, organism-specific biosystemAttenuation of the heat shock transcriptional response occurs during continuous exposure to intermediate heat shock conditions or upon recovery from stress (Abravaya et al. 1991). The attenuation pha...
    • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
      Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • HSF1-dependent transactivation, organism-specific biosystem (from REACTOME)
      HSF1-dependent transactivation, organism-specific biosystemAcquisition of DNA binding activity by HSF1 is necessary but insufficient for transcriptional activation (Cotto JJ et al. 1996; Trinklein ND et al. 2004). In addition to having a sequence-specific DN...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
      MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
    • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
      MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
    • NRF2 pathway, organism-specific biosystem (from WikiPathways)
      NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
      Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATPase activator activity TAS
    Traceable Author Statement
    more info
     
    ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    dnaJ homolog subfamily B member 1
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 1
    dnaJ protein homolog 1
    heat shock 40 kDa protein 1
    human DnaJ protein 1
    radial spoke 16 homolog B

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300914.1NP_001287843.1  dnaJ homolog subfamily B member 1 isoform 2

      See identical proteins and their annotated locations for NP_001287843.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      BC013157, BM795601, D49547, DA377896
      Consensus CDS
      CCDS74295.1
      UniProtKB/Swiss-Prot
      P25685
      Conserved Domains (1) summary
      cd10747
      Location:62226
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    2. NM_001313964.1NP_001300893.1  dnaJ homolog subfamily B member 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains alternate 5' terminal exons, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC009004, AC012318
      Consensus CDS
      CCDS74295.1
      UniProtKB/Swiss-Prot
      P25685
      Related
      ENSP00000444212.1, OTTHUMP00000271337, ENST00000396969.8, OTTHUMT00000465989
      Conserved Domains (1) summary
      cd10747
      Location:62226
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    3. NM_006145.2NP_006136.1  dnaJ homolog subfamily B member 1 isoform 1

      See identical proteins and their annotated locations for NP_006136.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC013157, BM795601, D49547, DB454482, HY032238, HY042250
      Consensus CDS
      CCDS12312.1
      UniProtKB/Swiss-Prot
      P25685
      UniProtKB/TrEMBL
      Q6FHS4
      Related
      ENSP00000254322.1, OTTHUMP00000271336, ENST00000254322.2, OTTHUMT00000465987
      Conserved Domains (1) summary
      COG0484
      Location:1340
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      14514764..14529821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722734.3XP_006722797.1  dnaJ homolog subfamily B member 1 isoform X1

      See identical proteins and their annotated locations for XP_006722797.1

      UniProtKB/Swiss-Prot
      P25685
      Conserved Domains (1) summary
      cd10747
      Location:62226
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    2. XM_006722733.1XP_006722796.1  dnaJ homolog subfamily B member 1 isoform X1

      See identical proteins and their annotated locations for XP_006722796.1

      UniProtKB/Swiss-Prot
      P25685
      Conserved Domains (1) summary
      cd10747
      Location:62226
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    3. XM_011527956.2XP_011526258.1  dnaJ homolog subfamily B member 1 isoform X1

      See identical proteins and their annotated locations for XP_011526258.1

      UniProtKB/Swiss-Prot
      P25685
      Conserved Domains (1) summary
      cd10747
      Location:62226
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      14625536..14640094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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