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    GTF2A1 general transcription factor IIA subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2957, updated on 25-May-2017
    Official Symbol
    GTF2A1provided by HGNC
    Official Full Name
    general transcription factor IIA subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4646
    See related
    Ensembl:ENSG00000165417 MIM:600520; Vega:OTTHUMG00000171414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TF2A1; TFIIA; TFIIAL; TFIIA-42
    Summary
    Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]
    Orthologs
    Location:
    14q31.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (81175452..81221231, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (81641796..81687575, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene thyroid stimulating hormone receptor Neighboring gene NMNAT1 pseudogene 1 Neighboring gene uncharacterized LOC101928462 Neighboring gene uncharacterized LOC105370594 Neighboring gene uncharacterized LOC101928504 Neighboring gene small nucleolar RNA, H/ACA box 79 Neighboring gene dynein light chain LC8-type 1 pseudogene 1 Neighboring gene uracil-DNA glycosylase pseudogene 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of general transcription factor IIA, 1, 19/37kDa (GTF2A1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ21525, MGC129969, MGC129970

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II repressing transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    transcription factor TFIIA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    transcription initiation factor IIA subunit 1
    Names
    TFIIA alpha, p55, isoform 1
    TFIIA alpha/beta subunits
    general transcription factor IIA 1
    general transcription factor IIA, 1, 19/37kDa
    glucose regulated protein, 58kD pseudogene
    transcription initiation factor TFIIA 42 kDa subunit

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278940.1NP_001265869.1  transcription initiation factor IIA subunit 1 isoform 3

      See identical proteins and their annotated locations for NP_001265869.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate exon and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL136040, BC050703, BC107156
      UniProtKB/Swiss-Prot
      P52655
      Conserved Domains (2) summary
      cd07976
      Location:266326
      TFIIA_alpha_beta_like; Precursor of TFIIA alpha and beta subunits and similar proteins
      pfam03153
      Location:45326
      TFIIA; Transcription factor IIA, alpha/beta subunit
    2. NM_015859.3NP_056943.1  transcription initiation factor IIA subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_056943.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL136040, BC050703, D14887
      Consensus CDS
      CCDS9873.1
      UniProtKB/Swiss-Prot
      P52655
      Related
      ENSP00000452454.1, OTTHUMP00000245978, ENST00000553612.5, OTTHUMT00000413309
      Conserved Domains (2) summary
      cd07976
      Location:316376
      TFIIA_alpha_beta_like; Precursor of TFIIA alpha and beta subunits and similar proteins
      pfam03153
      Location:13376
      TFIIA; Transcription factor IIA, alpha/beta subunit
    3. NM_201595.2NP_963889.1  transcription initiation factor IIA subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_963889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL136040, D14886
      Consensus CDS
      CCDS9874.1
      UniProtKB/Swiss-Prot
      P52655
      Related
      ENSP00000409492.2, OTTHUMP00000245980, ENST00000434192.2, OTTHUMT00000413311
      Conserved Domains (3) summary
      cd07976
      Location:277337
      TFIIA_alpha_beta_like; Precursor of TFIIA alpha and beta subunits and similar proteins
      cl21683
      Location:221
      TFIIA_alpha_beta_like; Precursor of TFIIA alpha and beta subunits and similar proteins
      pfam03153
      Location:1337
      TFIIA; Transcription factor IIA, alpha/beta subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      81175452..81221231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      81582217..81627845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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