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    GLUD2 glutamate dehydrogenase 2 [ Homo sapiens (human) ]

    Gene ID: 2747, updated on 14-Jan-2018
    Official Symbol
    GLUD2provided by HGNC
    Official Full Name
    glutamate dehydrogenase 2provided by HGNC
    Primary source
    HGNC:HGNC:4336
    See related
    Ensembl:ENSG00000182890 MIM:300144; Vega:OTTHUMG00000022320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GDH2; GLUDP1
    Summary
    The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]
    Orthologs
    Location:
    Xq24
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) X NC_000023.11 (121047608..121049942)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (120181462..120183796)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen family 47, member A1 Neighboring gene uncharacterized LOC105373328 Neighboring gene Cbl proto-oncogene like 1 pseudogene Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 1 Neighboring gene microRNA 3672

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of glutamate dehydrogenase 2 (GLUD2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    • Alanine, aspartate and glutamate metabolism, organism-specific biosystem (from KEGG)
      Alanine, aspartate and glutamate metabolism, organism-specific biosystem
      Alanine, aspartate and glutamate metabolism
    • Alanine, aspartate and glutamate metabolism, conserved biosystem (from KEGG)
      Alanine, aspartate and glutamate metabolism, conserved biosystem
      Alanine, aspartate and glutamate metabolism
    • Amino acid synthesis and interconversion (transamination), organism-specific biosystem (from REACTOME)
      Amino acid synthesis and interconversion (transamination), organism-specific biosystemThese reactions mediate the synthesis of aspartate, asparagine, glutamate, and glutamine from ammonia and intermediates of glycolysis, and allow the utilization of the carbon atoms from these four am...
    • Arginine biosynthesis, organism-specific biosystem (from KEGG)
      Arginine biosynthesis, organism-specific biosystem
      Arginine biosynthesis
    • Arginine biosynthesis, conserved biosystem (from KEGG)
      Arginine biosynthesis, conserved biosystem
      Arginine biosynthesis
    • Carbon metabolism, organism-specific biosystem (from KEGG)
      Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
    • Carbon metabolism, conserved biosystem (from KEGG)
      Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
    • D-Glutamine and D-glutamate metabolism, organism-specific biosystem (from KEGG)
      D-Glutamine and D-glutamate metabolism, organism-specific biosystem
      D-Glutamine and D-glutamate metabolism
    • D-Glutamine and D-glutamate metabolism, conserved biosystem (from KEGG)
      D-Glutamine and D-glutamate metabolism, conserved biosystem
      D-Glutamine and D-glutamate metabolism
    • GABA shunt, organism-specific biosystem (from BIOCYC)
      GABA shunt, organism-specific biosystemBackground : 4-AMINO-BUTYRATE "GABA" and : GLT are the most abundant neurotransmitters in mammalian brain. While : 4-AMINO-BUTYRATE "GABA" is the major inhibitory neurotransmitter, : GLT is an excit...
    • GABA shunt, conserved biosystem (from BIOCYC)
      GABA shunt, conserved biosystemBackground |FRAME: 4-AMINO-BUTYRATE "GABA"| and |FRAME: GLT| are the most abundant neurotransmitters in mammalian brain. While |FRAME: 4-AMINO-BUTYRATE "GABA"| is the major inhibitory neurotransmitt...
    • L-glutamate and L-glutamine biosynthesis, conserved biosystem (from BIOCYC)
      L-glutamate and L-glutamine biosynthesis, conserved biosystemPlease note: This collection of reactions does not represent the metabolism of a single organism. Rather, it is assembled from a variety of organisms. Its purpose is to provide an overview of the wa...
    • L-glutamate biosynthesis II, conserved biosystem (from BIOCYC)
      L-glutamate biosynthesis II, conserved biosystemGlutamate is biosynthesized in the mitochondrion from the tricarboxylic acid (TCA) cycle intermediate alpha-ketoglutarate. As shown in this pathway, glutamate dehydrogenase NAD(P)+ produces glutamat...
    • L-glutamate degradation X, conserved biosystem (from BIOCYC)
      L-glutamate degradation X, conserved biosystemIn this pathway |FRAME:GLT| is deaminated by an NAD(P)-dependent dehydrogenase, forming |FRAME:AMMONIA| and |FRAME:2-KETOGLUTARATE|, which is then fed to the |FRAME:TCA|. The deamination of |FRAME: G...
    • L-ornithine biosynthesis II, conserved biosystem (from BIOCYC)
      L-ornithine biosynthesis II, conserved biosystemGeneral Background |FRAME: L-ORNITHINE| is an amino acid, but it is not a component of proteins nor is it coded for by DNA. In mammals, it plays a role in the |FRAME: PWY-4984| for the disposal of a...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
      Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
    • Nitrogen metabolism, organism-specific biosystem (from KEGG)
      Nitrogen metabolism, organism-specific biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
    • Nitrogen metabolism, conserved biosystem (from KEGG)
      Nitrogen metabolism, conserved biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
    • Proximal tubule bicarbonate reclamation, organism-specific biosystem (from KEGG)
      Proximal tubule bicarbonate reclamation, organism-specific biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
    • Proximal tubule bicarbonate reclamation, conserved biosystem (from KEGG)
      Proximal tubule bicarbonate reclamation, conserved biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
    • glutamate biosynthesis/degradation, organism-specific biosystem (from BIOCYC)
      glutamate biosynthesis/degradation, organism-specific biosystemGeneral Background : GLT is a non-essential amino acid. It plays an essential role in the central nervous system as an excitatory neurotransmitter involved in long term potentiation which is vital f...
    • ornithine de novo biosynthesis, organism-specific biosystem (from BIOCYC)
      ornithine de novo biosynthesis, organism-specific biosystemGeneral Background : L-ORNITHINE is an amino acid, but it is not a component of proteins nor is it coded for by DNA. In mammals, it plays a role in the : PWY-4984 for the disposal of ammonia where i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ADP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamate dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leucine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    glutamate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamate catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    NOT cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    glutamate dehydrogenase 2, mitochondrial
    Names
    GDH 2
    glutamate dehydrogenase pseudogene 1
    testicular secretory protein Li 14
    NP_036216.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016456.1 RefSeqGene

      Range
      5001..7335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_012084.3NP_036216.2  glutamate dehydrogenase 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_036216.2

      Status: REVIEWED

      Source sequence(s)
      BC050732
      Consensus CDS
      CCDS14603.1
      UniProtKB/Swiss-Prot
      P49448
      UniProtKB/TrEMBL
      A0A140VK14
      Related
      ENSP00000327589.1, OTTHUMP00000023966, ENST00000328078.2, OTTHUMT00000058133
      Conserved Domains (3) summary
      cd01076
      Location:263548
      NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
      COG0334
      Location:104555
      GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
      pfam02812
      Location:113240
      ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p7 Primary Assembly

      Range
      121047608..121049942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      120092469..120094803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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