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    CDH11 cadherin 11 [ Homo sapiens (human) ]

    Gene ID: 1009, updated on 25-Sep-2016
    Official Symbol
    CDH11provided by HGNC
    Official Full Name
    cadherin 11provided by HGNC
    Primary source
    HGNC:HGNC:1750
    See related
    Ensembl:ENSG00000140937 HPRD:08960; MIM:600023; Vega:OTTHUMG00000137494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OB; CAD11; CDHOB; OSF-4
    Summary
    This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    16q21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (64943753..65126112, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (64916794..65160015, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984822 Neighboring gene uncharacterized LOC105371313 Neighboring gene uncharacterized LOC105371314 Neighboring gene uncharacterized LOC101927650 Neighboring gene long intergenic non-protein coding RNA 922

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    NHGRI GWA Catalog
    • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
      Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
      Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adherens junction organization TAS
    Traceable Author Statement
    more info
     
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    corticospinal tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    ossification NAS
    Non-traceable Author Statement
    more info
    PubMed 
    skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    cadherin-11
    Names
    cadherin 11, type 2, OB-cadherin (osteoblast)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029491.2 RefSeqGene

      Range
      4880..183264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001308392.1NP_001295321.1  cadherin-11 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AC010533, BQ007417, D21255, DA406052
      Consensus CDS
      CCDS81993.1
      UniProtKB/Swiss-Prot
      P55287
      Related
      ENSP00000377711, OTTHUMP00000174771, ENST00000394156, OTTHUMT00000268756
      Conserved Domains (2) summary
      cd11304
      Location:163264
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79157
      CA; Cadherin repeats
    2. NM_001330576.1NP_001317505.1  cadherin-11 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon, resulting in a distinct 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC010533, AC137643, BQ007417
      Consensus CDS
      CCDS81992.1
    3. NM_001797.3NP_001788.2  cadherin-11 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001788.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC010533, AC137643, AK291251, BQ007417
      Consensus CDS
      CCDS10803.1
      UniProtKB/Swiss-Prot
      P55287
      Related
      ENSP00000268603, OTTHUMP00000174770, ENST00000268603, OTTHUMT00000268755
      Conserved Domains (3) summary
      cd11304
      Location:163264
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79157
      CA; Cadherin repeats
      pfam01049
      Location:649787
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      64943753..65126112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005255762.2XP_005255819.1  

      See identical proteins and their annotated locations for XP_005255819.1

      UniProtKB/Swiss-Prot
      P55287
      Conserved Domains (3) summary
      cd11304
      Location:163264
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79157
      CA; Cadherin repeats
      pfam01049
      Location:649787
      Cadherin_C; Cadherin cytoplasmic region
    2. XM_005255763.2XP_005255820.1  

      See identical proteins and their annotated locations for XP_005255820.1

      UniProtKB/Swiss-Prot
      P55287
      Conserved Domains (3) summary
      cd11304
      Location:163264
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79157
      CA; Cadherin repeats
      pfam01049
      Location:649787
      Cadherin_C; Cadherin cytoplasmic region
    3. XM_005255761.3XP_005255818.1  

      See identical proteins and their annotated locations for XP_005255818.1

      UniProtKB/Swiss-Prot
      P55287
      Conserved Domains (3) summary
      cd11304
      Location:163264
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79157
      CA; Cadherin repeats
      pfam01049
      Location:649787
      Cadherin_C; Cadherin cytoplasmic region
    4. XM_017022830.1XP_016878319.1  

      Related
      ENSP00000457812, OTTHUMP00000249375, ENST00000566827, OTTHUMT00000420581
    5. XM_011522803.2XP_011521105.1  

      See identical proteins and their annotated locations for XP_011521105.1

      UniProtKB/Swiss-Prot
      P55287
      Conserved Domains (3) summary
      cd11304
      Location:163264
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79157
      CA; Cadherin repeats
      pfam01049
      Location:649787
      Cadherin_C; Cadherin cytoplasmic region

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      66385664..66564059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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