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    PIGB phosphatidylinositol glycan anchor biosynthesis class B [ Homo sapiens (human) ]

    Gene ID: 9488, updated on 22-Apr-2017
    Official Symbol
    PIGBprovided by HGNC
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis class Bprovided by HGNC
    Primary source
    HGNC:HGNC:8959
    See related
    Ensembl:ENSG00000069943 MIM:604122; Vega:OTTHUMG00000172654
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIG-B; GPI-MT-III
    Summary
    This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    15q21.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (55318935..55355648)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (55611133..55647906)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribosomal L24 domain containing 1 Neighboring gene RAB27A, member RAS oncogene family Neighboring gene PIGB opposite strand 1 Neighboring gene DNAAF4-CCPG1 readthrough (NMD candidate) Neighboring gene cell cycle progression 1 Neighboring gene microRNA 628 Neighboring gene chromosome 15 open reading frame 65 Neighboring gene dynein axonemal assembly factor 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC21236

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glycolipid mannosyltransferase activity TAS
    Traceable Author Statement
    more info
     
    mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    GPI anchor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mannosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    preassembly of GPI anchor in ER membrane TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    GPI mannosyltransferase 3
    Names
    GPI mannosyltransferase III
    dol-P-Man dependent GPI mannosyltransferase
    phosphatidylinositol glycan, class B
    phosphatidylinositol-glycan biosynthesis class B protein
    NP_004846.4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004855.4NP_004846.4  GPI mannosyltransferase 3

      See identical proteins and their annotated locations for NP_004846.4

      Status: REVIEWED

      Source sequence(s)
      AC018926, AK223330, DA598474
      Consensus CDS
      CCDS61641.1
      UniProtKB/Swiss-Prot
      Q92521
      Related
      ENSP00000164305.5, OTTHUMP00000248964, ENST00000164305.9, OTTHUMT00000419687
      Conserved Domains (1) summary
      pfam03901
      Location:62449
      Glyco_transf_22; Alg9-like mannosyltransferase family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      55318935..55355648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522235.2XP_011520537.1  GPI mannosyltransferase 3 isoform X1

      Conserved Domains (1) summary
      pfam03901
      Location:62434
      Glyco_transf_22; Alg9-like mannosyltransferase family
    2. XM_011522236.2XP_011520538.1  GPI mannosyltransferase 3 isoform X2

      Conserved Domains (1) summary
      pfam03901
      Location:62414
      Glyco_transf_22; Alg9-like mannosyltransferase family
    3. XM_011522237.2XP_011520539.1  GPI mannosyltransferase 3 isoform X3

      Conserved Domains (1) summary
      cl21590
      Location:7316
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    4. XM_005254795.4XP_005254852.1  GPI mannosyltransferase 3 isoform X4

      Conserved Domains (1) summary
      cl21590
      Location:1288
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    5. XM_017022732.1XP_016878221.1  GPI mannosyltransferase 3 isoform X5

    6. XM_017022730.1XP_016878219.1  GPI mannosyltransferase 3 isoform X3

      Conserved Domains (1) summary
      cl21590
      Location:7316
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    7. XM_017022731.1XP_016878220.1  GPI mannosyltransferase 3 isoform X3

      Conserved Domains (1) summary
      cl21590
      Location:7316
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    RNA

    1. XR_931950.2 RNA Sequence

    2. XR_001751423.1 RNA Sequence

    3. XR_001751422.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      55729600..55766338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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