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    TRIM24 tripartite motif containing 24 [ Homo sapiens (human) ]

    Gene ID: 8805, updated on 8-Oct-2017
    Official Symbol
    TRIM24provided by HGNC
    Official Full Name
    tripartite motif containing 24provided by HGNC
    Primary source
    HGNC:HGNC:11812
    See related
    Ensembl:ENSG00000122779 MIM:603406; Vega:OTTHUMG00000155820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA
    Summary
    The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    7q33-q34
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (138460334..138585588)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (138145079..138270333)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene prothymosin, alpha pseudogene Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 3 Neighboring gene ribosomal protein S3a pseudogene 28 Neighboring gene SVOP like Neighboring gene ribosomal protein L21 pseudogene 73 Neighboring gene ribosomal protein L17 pseudogene 27

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Papillary thyroid carcinoma
    MedGen: C0238463 OMIM: 188550 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat binds to TIF1 in 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • FGFR1 mutant receptor activation, organism-specific biosystem (from REACTOME)
      FGFR1 mutant receptor activation, organism-specific biosystemThe FGFR1 gene has been shown to be subject to activating mutations, chromosomal rearrangements and gene amplification leading to a variety of proliferative and developmental disorders depending on w...
    • Oncogenic MAPK signaling, organism-specific biosystem (from REACTOME)
      Oncogenic MAPK signaling, organism-specific biosystemThe importance of the RAS/RAF/MAPK cascade in regulating cellular proliferation, differentiation and survival is highlighted by the fact that components of the pathway are mutated with high frequency...
    • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Androgen receptor activity, organism-specific biosystem
      Regulation of Androgen receptor activity
    • Signaling by BRAF and RAF fusions, organism-specific biosystem (from REACTOME)
      Signaling by BRAF and RAF fusions, organism-specific biosystemIn addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et ...
    • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR in disease, organism-specific biosystemA number of skeletal and developmental diseases have been shown to arise as a result of mutations in the FGFR1, 2 and 3 genes. These include dwarfism syndromes (achondroplasia, hypochondroplasia and...
    • Signaling by FGFR1 in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR1 in disease, organism-specific biosystemThe FGFR1 gene has been shown to be subject to activating mutations, chromosomal rearrangements and gene amplification leading to a variety of proliferative and developmental disorders depending on w...
    • Signaling by cytosolic FGFR1 fusion mutants, organism-specific biosystem (from REACTOME)
      Signaling by cytosolic FGFR1 fusion mutants, organism-specific biosystem8p11 myeloproliferative syndrome (EMS) is an aggressive disorder that is associated with a translocation event at the FGFR1 gene on chromosome 8p11. Typical symptoms upon diagnosis include eosinophi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    estrogen response element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ligand-dependent nuclear receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vitamin D receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    nuclear euchromatin IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perichromatin fibrils IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    transcription intermediary factor 1-alpha
    Names
    E3 ubiquitin-protein ligase TRIM24
    RING finger protein 82
    RING-type E3 ubiquitin transferase TIF1-alpha
    TIF1-alpha
    transcriptional intermediary factor 1
    NP_003843.3
    NP_056989.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023286.1 RefSeqGene

      Range
      5001..130255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003852.3NP_003843.3  transcription intermediary factor 1-alpha isoform b

      See identical proteins and their annotated locations for NP_003843.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AF119042, AK075306, BC028689, CB988362
      Consensus CDS
      CCDS47720.1
      UniProtKB/Swiss-Prot
      O15164
      UniProtKB/TrEMBL
      A0A024R784
      Related
      ENSP00000390829.2, OTTHUMP00000208725, ENST00000415680.6, OTTHUMT00000341820
      Conserved Domains (7) summary
      cd05502
      Location:866973
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:266392
      BBC; B-Box C-terminal domain
      smart00336
      Location:158194
      BBOX; B-Box-type zinc finger
      smart00818
      Location:432519
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      smart00184
      Location:5682
      RING; Ring finger
      cd00021
      Location:221259
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15622
      Location:794836
      PHD_TIF1alpha; PHD finger found in transcription intermediary factor 1-alpha (TIF1-alpha)
    2. NM_015905.2NP_056989.2  transcription intermediary factor 1-alpha isoform a

      See identical proteins and their annotated locations for NP_056989.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AA844662, AK075306, BC028689, CB988362
      Consensus CDS
      CCDS5847.1
      UniProtKB/Swiss-Prot
      O15164
      Related
      ENSP00000340507.4, OTTHUMP00000208723, ENST00000343526.8, OTTHUMT00000341814
      Conserved Domains (6) summary
      cd05502
      Location:9001007
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:266392
      BBC; B-Box C-terminal domain
      smart00336
      Location:158194
      BBOX; B-Box-type zinc finger
      smart00184
      Location:5682
      RING; Ring finger
      cd00021
      Location:221259
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15622
      Location:828870
      PHD_TIF1alpha; PHD finger found in transcription intermediary factor 1-alpha (TIF1-alpha)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      138460334..138585588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      138078355..138203624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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