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    TRAF3 TNF receptor associated factor 3 [ Homo sapiens (human) ]

    Gene ID: 7187, updated on 9-Jul-2017
    Official Symbol
    TRAF3provided by HGNC
    Official Full Name
    TNF receptor associated factor 3provided by HGNC
    Primary source
    HGNC:HGNC:12033
    See related
    Ensembl:ENSG00000131323 MIM:601896; Vega:OTTHUMG00000171902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAP1; LAP1; CAP-1; CRAF1; IIAE5; CD40bp
    Summary
    The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]
    Orthologs
    Location:
    14q32.32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (102777479..102911500)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103243816..103377837)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2323 Neighboring gene RNA, 7SL, cytoplasmic 546, pseudogene Neighboring gene REST corepressor 1 Neighboring gene ribosomal protein L23a pseudogene 11 Neighboring gene RNA, U6 small nuclear 1316, pseudogene Neighboring gene CDC42 binding protein kinase beta Neighboring gene amnion associated transmembrane protein Neighboring gene ribosomal protein L13 pseudogene 6

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Herpes simplex encephalitis, susceptibility to, 3
    MedGen: C3553868 OMIM: 614849 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells PubMed
    tat HIV-1 Tat-induced upregulation of microRNA 32 results in downregulation of TRAF3 in human microglial cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
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    • Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystem (from REACTOME)
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    • Apoptosis, organism-specific biosystem (from WikiPathways)
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      CD40/CD40L signaling, organism-specific biosystem
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      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
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    • Diseases of Immune System, organism-specific biosystem (from REACTOME)
      Diseases of Immune System, organism-specific biosystemThe immune system is a complex network of the biological processes that provide defense mechanisms during infection or in response to an intrinsic danger signal. Compromised immune response may prese...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
      IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
    • IL-17 signaling pathway, conserved biosystem (from KEGG)
      IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
    • IL17 signaling pathway, organism-specific biosystem (from WikiPathways)
      IL17 signaling pathway, organism-specific biosystemInterleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
      MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem (from REACTOME)
      Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystemAs with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune...
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      Ovarian tumor domain proteases, organism-specific biosystemHumans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family ...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystemRANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important mol...
    • RIG-I-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
      RIG-I-like Receptor Signaling, organism-specific biosystemViral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initia...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Regulation of toll-like receptor signaling pathway, organism-specific biosystem
      Regulation of toll-like receptor signaling pathway
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • TLR4 Signaling and Tolerance, organism-specific biosystem (from WikiPathways)
      TLR4 Signaling and Tolerance, organism-specific biosystemThis pathway is based on the figure 2 of "Toll-like Receptors: Novel Pharmacological Targets for the Treatment of Neurological Diseases" and figure 2 of "Toll-like receptor and its roles in myocardia...
    • TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, organism-specific biosystem (from REACTOME)
      TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, organism-specific biosystemActivation of NF-kB is fundamental to signal transduction by members of the TNFRSF. Expression of NF-kB target genes is essential for mounting innate immune responses to infectious microorganisms but...
    • TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, organism-specific biosystemTNF related weak inducer of apoptosis (TWEAK) is a small pleiotropic cytokine of the TNF super family and its gene is located at chromosome 17p13.1. TWEAK has been reported to be expressed in tissues...
    • TNF signaling pathway, organism-specific biosystem (from KEGG)
      TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF signaling pathway, conserved biosystem (from KEGG)
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    • TNFR2 non-canonical NF-kB pathway, organism-specific biosystem (from REACTOME)
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    • TRAF3 deficiency - HSE, organism-specific biosystem (from REACTOME)
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    • TRAF3-dependent IRF activation pathway, organism-specific biosystem (from REACTOME)
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    • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
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    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    thioesterase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tumor necrosis factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    TRIF-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Toll signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of type I interferon production TAS
    Traceable Author Statement
    more info
     
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    CD40 receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    TNF receptor-associated factor 3
    Names
    CD40 associated protein 1
    CD40 binding protein
    CD40 receptor associated factor 1
    LMP1-associated protein 1
    RING-type E3 ubiquitin transferase TRAF3
    NP_001186356.1
    NP_003291.2
    NP_663777.1
    NP_663778.1
    XP_011535418.1
    XP_011535419.1
    XP_011535420.1
    XP_016877106.1
    XP_016877107.1
    XP_016877108.1
    XP_016877109.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027973.1 RefSeqGene

      Range
      5001..139022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_229

    mRNA and Protein(s)

    1. NM_001199427.1NP_001186356.1  TNF receptor-associated factor 3 isoform 3

      See identical proteins and their annotated locations for NP_001186356.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame coding segment compared to variant 1. The resulting isoform (2) lacks an internal region as compared to isoform 1.
      Source sequence(s)
      AK303172, AL117209, AL132801, BQ000015, U21092
      Consensus CDS
      CCDS55946.1
      UniProtKB/Swiss-Prot
      Q13114
      Related
      ENSP00000445998.1, OTTHUMP00000247098, ENST00000539721.5, OTTHUMT00000415737
      Conserved Domains (4) summary
      smart00184
      Location:5388
      RING; Ring finger
      cd03777
      Location:295480
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136190
      zf-TRAF; TRAF-type zinc finger
      pfam17082
      Location:224283
      Spc29; Spindle Pole Component 29
    2. NM_003300.3NP_003291.2  TNF receptor-associated factor 3 isoform 1

      See identical proteins and their annotated locations for NP_003291.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL117209, AL132801, BQ000015, BX247977, U21092
      Consensus CDS
      CCDS9975.1
      UniProtKB/Swiss-Prot
      Q13114
      Related
      ENSP00000454207.1, OTTHUMP00000247096, ENST00000560371.5, OTTHUMT00000415735
      Conserved Domains (5) summary
      cd03777
      Location:378563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:5691
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136192
      zf-TRAF; TRAF-type zinc finger
      pfam15272
      Location:263321
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17082
      Location:307366
      Spc29; Spindle Pole Component 29
    3. NM_145725.2NP_663777.1  TNF receptor-associated factor 3 isoform 1

      See identical proteins and their annotated locations for NP_663777.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL117209, AL132801, BQ000015, BX247977, U21092
      Consensus CDS
      CCDS9975.1
      UniProtKB/Swiss-Prot
      Q13114
      Related
      ENSP00000376500.2, OTTHUMP00000247097, ENST00000392745.6, OTTHUMT00000415736
      Conserved Domains (5) summary
      cd03777
      Location:378563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:5691
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136192
      zf-TRAF; TRAF-type zinc finger
      pfam15272
      Location:263321
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17082
      Location:307366
      Spc29; Spindle Pole Component 29
    4. NM_145726.2NP_663778.1  TNF receptor-associated factor 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding segment compared to variant 1. The resulting isoform (2) lacks an internal region compared to isoform 1.
      Source sequence(s)
      AL117209, AL132801, BQ000015, BX247977, U21092
      Consensus CDS
      CCDS9976.1
      UniProtKB/Swiss-Prot
      Q13114
      UniProtKB/TrEMBL
      A6NHG8
      Related
      ENSP00000328003.4, ENST00000347662.8
      Conserved Domains (4) summary
      cd03777
      Location:353538
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      TIGR04527
      Location:235361
      mycoplas_twoTM; two transmembrane protein
      pfam00097
      Location:5691
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136192
      zf-TRAF; TRAF-type zinc finger

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      102777479..102911500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021620.1XP_016877109.1  TNF receptor-associated factor 3 isoform X6

    2. XM_011537118.2XP_011535420.1  TNF receptor-associated factor 3 isoform X5

      See identical proteins and their annotated locations for XP_011535420.1

      UniProtKB/Swiss-Prot
      Q13114
      Conserved Domains (4) summary
      smart00184
      Location:5388
      RING; Ring finger
      cd03777
      Location:295480
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136190
      zf-TRAF; TRAF-type zinc finger
      pfam17082
      Location:224283
      Spc29; Spindle Pole Component 29
    3. XM_011537117.2XP_011535419.1  TNF receptor-associated factor 3 isoform X4

      Conserved Domains (4) summary
      cd03777
      Location:322507
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:5691
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136192
      zf-TRAF; TRAF-type zinc finger
      pfam17082
      Location:251310
      Spc29; Spindle Pole Component 29
    4. XM_011537116.2XP_011535418.1  TNF receptor-associated factor 3 isoform X3

      Conserved Domains (4) summary
      smart00184
      Location:5388
      RING; Ring finger
      cd03777
      Location:326511
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      TIGR04527
      Location:208334
      mycoplas_twoTM; two transmembrane protein
      pfam02176
      Location:136190
      zf-TRAF; TRAF-type zinc finger
    5. XM_017021617.1XP_016877106.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/Swiss-Prot
      Q13114
      Conserved Domains (5) summary
      cd03777
      Location:378563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:5691
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136192
      zf-TRAF; TRAF-type zinc finger
      pfam15272
      Location:263321
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17082
      Location:307366
      Spc29; Spindle Pole Component 29
    6. XM_017021619.1XP_016877108.1  TNF receptor-associated factor 3 isoform X2

      UniProtKB/TrEMBL
      A6NHG8
      Conserved Domains (4) summary
      cd03777
      Location:353538
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      TIGR04527
      Location:235361
      mycoplas_twoTM; two transmembrane protein
      pfam00097
      Location:5691
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136192
      zf-TRAF; TRAF-type zinc finger
    7. XM_017021618.1XP_016877107.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/Swiss-Prot
      Q13114
      Conserved Domains (5) summary
      cd03777
      Location:378563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:5691
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136192
      zf-TRAF; TRAF-type zinc finger
      pfam15272
      Location:263321
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17082
      Location:307366
      Spc29; Spindle Pole Component 29

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      103181586..103315592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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