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    PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha [ Homo sapiens (human) ]

    Gene ID: 5573, updated on 22-Sep-2016
    Official Symbol
    PRKAR1Aprovided by HGNC
    Official Full Name
    protein kinase cAMP-dependent type I regulatory subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:9388
    See related
    Ensembl:ENSG00000108946 HPRD:01786; MIM:188830; Vega:OTTHUMG00000180128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; ACRDYS1
    Summary
    cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
    Orthologs
    Location:
    17q24.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (68413623..68551316)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (66507921..66547457)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene solute carrier family 16 member 6 Neighboring gene arylsulfatase G Neighboring gene microRNA 635 Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene uncharacterized LOC105371873 Neighboring gene FAM20A, golgi associated secretory pathway pseudokinase Neighboring gene long intergenic non-protein coding RNA 1482

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The exposure of CD4+ T cells to HIV gp120 results in a long-lasting hyporesponsiveness to antigen stimulation through protein kinase A-mediated signaling PubMed
    env Treatment of normal human fibroblasts with HIV-1 gp120 protein results in a significant decrease in the levels of 8-azido-[32P]cAMP binding to RI and RII domains of protein kinase A (PKA) and in PKA activity PubMed
    Nef nef Serine residues Ser6 and Ser9 of HIV-1 Nef are phosphorylated by PKA in a cell-free system; intracellularly, only Ser9 of HIV-1 NL4-3 Nef is phosphorylated by PKA in resting peripheral blood mononuclear cells PubMed
    Tat tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
    Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
    Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
    matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
    gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
    gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed

    Go to the HIV-1, Human Interaction Database

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      DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
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      DARPP-32 events, organism-specific biosystemDopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation D...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
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    • Downstream signaling of activated FGFR2, organism-specific biosystem (from REACTOME)
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      Downstream signaling of activated FGFR3, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
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      Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, organism-specific biosystemGlucagon-like Peptide-1 (GLP-1) is secreted by L-cells in the intestine in response to glucose and fatty acids. GLP-1 circulates to the beta cells of the pancreas where it binds a G-protein coupled r...
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      Hedgehog 'off' state, organism-specific biosystemHedgehog is a secreted morphogen that has evolutionarily conserved roles in body organization by regulating the activity of the Ci/Gli transcription factor family. In Drosophila in the absence of Hh ...
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      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
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      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
      Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Opioid Signalling, organism-specific biosystem (from REACTOME)
      Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
    • PKA activation, organism-specific biosystem (from REACTOME)
      PKA activation, organism-specific biosystemA number of inactive tetrameric PKA holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. When cAMP binds t...
    • PKA activation in glucagon signalling, organism-specific biosystem (from REACTOME)
      PKA activation in glucagon signalling, organism-specific biosystemAdenylate cyclase catalyses the synthesis of cyclic AMP (cAMP) from ATP. In the absence of cAMP, protein kinase A (PKA) exists as inactive tetramers of two catalytic subunits and two regulatory subun...
    • PKA-mediated phosphorylation of CREB, organism-specific biosystem (from REACTOME)
      PKA-mediated phosphorylation of CREB, organism-specific biosystemCyclic adenosine 3',5'-monophosphate (cAMP) induces gene transcription through activation of cAMP-dependent protein kinase (PKA), and subsequent phosphorylation of the transcription factor cAMP respo...
    • PLC beta mediated events, organism-specific biosystem (from REACTOME)
      PLC beta mediated events, organism-specific biosystemThe phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. PLC hydrolyzes phosphatidylinosito...
    • PLC-gamma1 signalling, organism-specific biosystem (from REACTOME)
      PLC-gamma1 signalling, organism-specific biosystemThe activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosph...
    • Phospholipase C-mediated cascade: FGFR1, organism-specific biosystem (from REACTOME)
      Phospholipase C-mediated cascade: FGFR1, organism-specific biosystemPhospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 dom...
    • Phospholipase C-mediated cascade; FGFR2, organism-specific biosystem (from REACTOME)
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    • Phospholipase C-mediated cascade; FGFR3, organism-specific biosystem (from REACTOME)
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    • Phospholipase C-mediated cascade; FGFR4, organism-specific biosystem (from REACTOME)
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    • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
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    • miRs in Muscle Cell Differentiation, organism-specific biosystem (from WikiPathways)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC17251, DKFZp779L0468

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cAMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cAMP-dependent protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP-dependent protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase A catalytic subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of protein kinase A activity TAS
    Traceable Author Statement
    more info
     
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucagon stimulus TAS
    Traceable Author Statement
    more info
     
    female meiotic division IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    renal water homeostasis TAS
    Traceable Author Statement
    more info
     
    sarcomere organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cAMP-dependent protein kinase complex IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary base TAS
    Traceable Author Statement
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    cAMP-dependent protein kinase type I-alpha regulatory subunit
    Names
    Carney complex type 1
    cAMP-dependent protein kinase regulatory subunit RIalpha
    cAMP-dependent protein kinase type I-alpha regulatory chain
    protein kinase A type 1a regulatory subunit
    protein kinase, cAMP-dependent, regulatory subunit type I alpha
    protein kinase, cAMP-dependent, regulatory, type I, alpha
    tissue-specific extinguisher 1
    NP_001263218.1
    NP_001263219.1
    NP_001265362.1
    NP_002725.1
    NP_997636.1
    NP_997637.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007093.3 RefSeqGene

      Range
      5001..142694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_514

    mRNA and Protein(s)

    1. NM_001276289.1NP_001263218.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

      See identical proteins and their annotated locations for NP_001263218.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains two alternate exons in place of the first 5' UTR exon compared to variant 2. Variants 1, 2, 3, 4, and 6 all encode the same isoform (a).
      Source sequence(s)
      AC079210, AY007115, BC093042, DA219203
      Consensus CDS
      CCDS11678.1
      UniProtKB/Swiss-Prot
      P10644
      UniProtKB/TrEMBL
      B2R5T5
      Related
      ENSP00000445625, OTTHUMP00000263407, ENST00000536854, OTTHUMT00000449887
      Conserved Domains (3) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      COG0664
      Location:249359
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    2. NM_001276290.1NP_001263219.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate exon in place of the last exon compared to variant 2. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Note that the 5' UTR splicing pattern of this variant has not been determined.
      Source sequence(s)
      AW732104, BC093042
      Consensus CDS
      CCDS62307.1
      UniProtKB/Swiss-Prot
      P10644
      Related
      ENSP00000468106, OTTHUMP00000263415, ENST00000588188, OTTHUMT00000449895
      Conserved Domains (3) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      COG0664
      Location:131257
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:137246
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    3. NM_001278433.1NP_001265362.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

      See identical proteins and their annotated locations for NP_001265362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an alternate exon in place of the first 5' UTR exon compared to variant 2. Variants 1, 2, 3, 4, and 6 all encode the same isoform (a).
      Source sequence(s)
      AY007115, BC036285, BC093042, DA108801, M18468
      Consensus CDS
      CCDS11678.1
      UniProtKB/Swiss-Prot
      P10644
      UniProtKB/TrEMBL
      B2R5T5
      Conserved Domains (3) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      COG0664
      Location:249359
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    4. NM_002734.4NP_002725.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

      See identical proteins and their annotated locations for NP_002725.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains an alternate exon in place of the first 5' UTR exon compared to variant 2. Variants 1, 2, 3, 4, and 6 all encode the same isoform (a).
      Source sequence(s)
      AC079210, AY007115, BC036285, DA219203
      Consensus CDS
      CCDS11678.1
      UniProtKB/Swiss-Prot
      P10644
      UniProtKB/TrEMBL
      B2R5T5
      Related
      ENSP00000464977, OTTHUMP00000263405, ENST00000589228, OTTHUMT00000449884
      Conserved Domains (3) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      COG0664
      Location:249359
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    5. NM_212471.2NP_997636.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

      See identical proteins and their annotated locations for NP_997636.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, 3, 4, and 6 all encode the same isoform (a).
      Source sequence(s)
      AC079210, AY007115, BC093042, DA413808
      Consensus CDS
      CCDS11678.1
      UniProtKB/Swiss-Prot
      P10644
      UniProtKB/TrEMBL
      B2R5T5
      Related
      ENSP00000351410, OTTHUMP00000263402, ENST00000358598, OTTHUMT00000449880
      Conserved Domains (3) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      COG0664
      Location:249359
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    6. NM_212472.2NP_997637.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

      See identical proteins and their annotated locations for NP_997637.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in place of the first 5' UTR exon compared to variant 2. Variants 1, 2, 3, 4, and 6 all encode the same isoform (a).
      Source sequence(s)
      AC079210, AL535889, AY007115, BC093042, DA219203
      Consensus CDS
      CCDS11678.1
      UniProtKB/Swiss-Prot
      P10644
      UniProtKB/TrEMBL
      B2R5T5
      Related
      ENSP00000376475, ENST00000392711
      Conserved Domains (3) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      COG0664
      Location:249359
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      68413623..68551316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524985.2XP_011523287.1  

      See identical proteins and their annotated locations for XP_011523287.1

      UniProtKB/Swiss-Prot
      P10644
      UniProtKB/TrEMBL
      B2R5T5
      Conserved Domains (3) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      COG0664
      Location:249359
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    2. XM_011524983.2XP_011523285.1  

      See identical proteins and their annotated locations for XP_011523285.1

      UniProtKB/Swiss-Prot
      P10644
      UniProtKB/TrEMBL
      B2R5T5
      Related
      ENSP00000466459, OTTHUMP00000263413, ENST00000586397, OTTHUMT00000449893
      Conserved Domains (3) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      COG0664
      Location:249359
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    3. XM_011524984.2XP_011523286.1  

      See identical proteins and their annotated locations for XP_011523286.1

      UniProtKB/Swiss-Prot
      P10644
      UniProtKB/TrEMBL
      B2R5T5
      Conserved Domains (3) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      COG0664
      Location:249359
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      66474424..66612184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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