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    MET MET proto-oncogene, receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 4233, updated on 19-Nov-2017
    Official Symbol
    METprovided by HGNC
    Official Full Name
    MET proto-oncogene, receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:7029
    See related
    Ensembl:ENSG00000105976 MIM:164860; Vega:OTTHUMG00000023299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HGFR; AUTS9; RCCP2; c-Met; DFNB97
    Summary
    This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
    Orthologs
    Location:
    7q31.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (116672359..116798386)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116312406..116438440)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene caveolin 1 Neighboring gene long intergenic non-protein coding RNA 1510 Neighboring gene KIAA1468 pseudogene Neighboring gene capping actin protein of muscle Z-line alpha subunit 2 Neighboring gene uncharacterized LOC105375465 Neighboring gene RNA, 5S ribosomal pseudogene 239

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Deafness, autosomal recessive 97
    MedGen: C4084709 OMIM: 616705 GeneReviews: Not available
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    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
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    Osteofibrous dysplasia
    MedGen: C1709353 OMIM: 607278 GeneReviews: Not available
    Compare labs
    Renal cell carcinoma, papillary, 1
    MedGen: C0007134 OMIM: 605074 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated (2012-09-06)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated (2012-09-06)

    ClinGen Genome Curation Page

    NHGRI GWAS Catalog

    Description
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog
    Genetic determinants of P wave duration and PR segment.
    NHGRI GWA Catalog
    Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
    NHGRI GWA Catalog
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    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
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    • Proteoglycans in cancer, conserved biosystem (from KEGG)
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    • RAF/MAP kinase cascade, organism-specific biosystem (from REACTOME)
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    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
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    • Rap1 signaling pathway, conserved biosystem (from KEGG)
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    • Ras signaling pathway, organism-specific biosystem (from KEGG)
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    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
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    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
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    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
      Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemThe lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell...
    • SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
      SHC1 events in EGFR signaling, organism-specific biosystemGRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.
    • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
      SOS-mediated signalling, organism-specific biosystemSOS is recruited to the plasma membrane and mediates activation of Ras.
    • Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
      Sema4D in semaphorin signaling, organism-specific biosystemSemaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cyste...
    • Sema4D mediated inhibition of cell attachment and migration, organism-specific biosystem (from REACTOME)
      Sema4D mediated inhibition of cell attachment and migration, organism-specific biosystemRepulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppressio...
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
      Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by Leptin, organism-specific biosystem (from REACTOME)
      Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
    • Signaling by MET, organism-specific biosystem (from REACTOME)
      Signaling by MET, organism-specific biosystemMET is a receptor tyrosine kinase (RTK) (Cooper et al. 1984, Park et al. 1984) activated by binding to its ligand, Hepatocyte growth factor/Scatter factor (HGF/SF) (Bottaro et al. 1991, Naldini et al...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
      Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by TCPTP, organism-specific biosystem
      Signaling events mediated by TCPTP
    • Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
      Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
      Signaling of Hepatocyte Growth Factor Receptor
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Signalling to ERKs, organism-specific biosystem (from REACTOME)
      Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
    • Signalling to RAS, organism-specific biosystem (from REACTOME)
      Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
    • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
      Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
    • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
      Stabilization and expansion of the E-cadherin adherens junction
    • Syndecan-1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-1-mediated signaling events, organism-specific biosystem
      Syndecan-1-mediated signaling events
    • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
    • a6b1 and a6b4 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      a6b1 and a6b4 Integrin signaling, organism-specific biosystem
      a6b1 and a6b4 Integrin signaling
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Ras guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    hepatocyte growth factor-activated receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    MAPK cascade TAS
    Traceable Author Statement
    more info
     
    branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    endothelial cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    entry of bacterium into host cell TAS
    Traceable Author Statement
    more info
     
    establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of autophagy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of hydrogen peroxide-mediated programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of thrombin-activated receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling TAS
    Traceable Author Statement
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    semaphorin-plexin signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    hepatocyte growth factor receptor
    Names
    HGF receptor
    HGF/SF receptor
    SF receptor
    proto-oncogene c-Met
    scatter factor receptor
    tyrosine-protein kinase Met
    NP_000236.2
    NP_001120972.1
    NP_001311330.1
    NP_001311331.1
    XP_006716053.1
    XP_011514525.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008996.1 RefSeqGene

      Range
      5001..130982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_662

    mRNA and Protein(s)

    1. NM_000245.3NP_000236.2  hepatocyte growth factor receptor isoform b preproprotein

      See identical proteins and their annotated locations for NP_000236.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AA278232, AI630755, BX648782, DB223186, X54559
      Consensus CDS
      CCDS43636.1
      UniProtKB/Swiss-Prot
      P08581
      UniProtKB/TrEMBL
      A0A024R759
      Related
      ENSP00000380860.3, OTTHUMP00000069168, ENST00000397752.7, OTTHUMT00000141947
      Conserved Domains (8) summary
      cd11278
      Location:25516
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:519561
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:838934
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:657740
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563656
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:742837
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:10821343
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam07714
      Location:10781337
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_001127500.2NP_001120972.1  hepatocyte growth factor receptor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001120972.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC002543, AI630755, BC130420, BX648782, DB223186, J02958
      Consensus CDS
      CCDS47689.1
      UniProtKB/Swiss-Prot
      P08581
      UniProtKB/TrEMBL
      A0A024R728
      Related
      ENSP00000317272.6, OTTHUMP00000024917, ENST00000318493.10, OTTHUMT00000059620
      Conserved Domains (8) summary
      cd11278
      Location:25516
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:519561
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:856952
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:657740
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563656
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:11001361
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam07714
      Location:10961355
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:742855
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    3. NM_001324401.1NP_001311330.1  hepatocyte growth factor receptor isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform c, which lacks a portion of the beta subunit.
      Source sequence(s)
      DB223186, EU176015
      UniProtKB/TrEMBL
      E6Y365
      Related
      ENSP00000410980.2, ENST00000436117.2
      Conserved Domains (6) summary
      cd11278
      Location:25516
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:519561
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:838918
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:657740
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563656
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cl15674
      Location:742837
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    4. NM_001324402.1NP_001311331.1  hepatocyte growth factor receptor isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes isoform d, which lacks a predicted signal peptide compared to isoforms a-c.
      Source sequence(s)
      AC002080, AC002543, AC004416, AI630755
      UniProtKB/TrEMBL
      B4DLF5
      Conserved Domains (8) summary
      smart00423
      Location:89131
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:408504
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:227310
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:133226
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:652913
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam07714
      Location:648907
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:312407
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:186
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      116672359..116798386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516223.1XP_011514525.1  hepatocyte growth factor receptor isoform X1

      Conserved Domains (8) summary
      cd11278
      Location:44535
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:538580
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:857953
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:676759
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:582675
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:761856
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:11011362
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam07714
      Location:10971356
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_006715990.2XP_006716053.1  hepatocyte growth factor receptor isoform X2

      See identical proteins and their annotated locations for XP_006716053.1

      UniProtKB/TrEMBL
      B4DLF5
      Conserved Domains (8) summary
      smart00423
      Location:89131
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:408504
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:227310
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:133226
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:652913
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam07714
      Location:648907
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:312407
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:186
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RNA

    1. XR_001744772.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      116246017..116372044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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